Fragmentation analysis by superconducting ion detectors in matrix-assisted laser desorption/ionization (MALDI)

M. Ohkubo; Y. Shigeri; T. Kinumi; N. Saito; M. Ukibe; Y. E. Chen; A. Kushino; A. Kurokawa; H. Sato; S. Ichimura

doi:10.1016/j.nima.2005.12.137

Fragmentation analysis by superconducting ion detectors in matrix-assisted laser desorption/ionization (MALDI)

M. Ohkubo^*, Y. Shigeri, T. Kinumi, N. Saito, M. Ukibe, Y. E. Chen, A. Kushino, A. Kurokawa, H. Sato, S. Ichimura

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Fragmentation of precursor ions of peptides or proteins is very promising for sequencing with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (TOF-MS). Neutral fragments as well as ions produced by post-source decay (PSD) were measured by a superconducting tunnel junction detector in a linear TOF-MS. It has been demonstrated that the PSD fragments are observable as event bands with different kinetic energies at the same TOF as that of the precursor ions of polystyrene with a nominal mass of 200 kDa and bovine serum albumin of 66.43 kDa.

Original language	English
Pages (from-to)	779-781
Number of pages	3
Journal	Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
Volume	559
Issue number	2
DOIs	https://doi.org/10.1016/j.nima.2005.12.137
Publication status	Published - 2006 Apr 14
Externally published	Yes

Keywords

Mass spectroscopy
Post-source decay
Superconducting tunnel junction

ASJC Scopus subject areas

Nuclear and High Energy Physics
Instrumentation

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10.1016/j.nima.2005.12.137

Cite this

Ohkubo, M., Shigeri, Y., Kinumi, T., Saito, N., Ukibe, M., Chen, Y. E., Kushino, A., Kurokawa, A., Sato, H., & Ichimura, S. (2006). Fragmentation analysis by superconducting ion detectors in matrix-assisted laser desorption/ionization (MALDI). Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 559(2), 779-781. https://doi.org/10.1016/j.nima.2005.12.137

Fragmentation analysis by superconducting ion detectors in matrix-assisted laser desorption/ionization (MALDI). / Ohkubo, M.; Shigeri, Y.; Kinumi, T. et al.

In: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Vol. 559, No. 2, 14.04.2006, p. 779-781.

Research output: Contribution to journal › Article › peer-review

Ohkubo, M, Shigeri, Y, Kinumi, T, Saito, N, Ukibe, M, Chen, YE, Kushino, A, Kurokawa, A, Sato, H & Ichimura, S 2006, 'Fragmentation analysis by superconducting ion detectors in matrix-assisted laser desorption/ionization (MALDI)', Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, vol. 559, no. 2, pp. 779-781. https://doi.org/10.1016/j.nima.2005.12.137

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AU - Ohkubo, M.

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AU - Kinumi, T.

AU - Saito, N.

AU - Ukibe, M.

AU - Chen, Y. E.

AU - Kushino, A.

AU - Kurokawa, A.

AU - Sato, H.

AU - Ichimura, S.

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AB - Fragmentation of precursor ions of peptides or proteins is very promising for sequencing with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (TOF-MS). Neutral fragments as well as ions produced by post-source decay (PSD) were measured by a superconducting tunnel junction detector in a linear TOF-MS. It has been demonstrated that the PSD fragments are observable as event bands with different kinetic energies at the same TOF as that of the precursor ions of polystyrene with a nominal mass of 200 kDa and bovine serum albumin of 66.43 kDa.

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Fragmentation analysis by superconducting ion detectors in matrix-assisted laser desorption/ionization (MALDI)

Abstract

Keywords

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