Fragmentation of Poly(lactic acid) nanosheets and patchwork treatment for burn wounds

Yosuke Okamura, Koki Kabata, Manabu Kinoshita, Hiromi Miyazaki, Akihiro Saito, Toshinori Fujie, Shinya Ohtsubo, Daizoh Saitoh, Shinji Takeoka

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Freestanding poly(L-lactic acid) (PLLA) nanosheets are mass-produced by a simple combination of a spin-coating-assisted multi-layering process and a peeling technique. The resulting PLLA nanosheets are fragmented by homogenization and then reconstructed into a "patchwork" sheet on various surfaces without any adhesive reagents. The patchwork is shown to offer excellent protection against burn wound infection with Pseudomonas aeruginosa, and may therefore be an alternative to conventional burn therapy for prevention of infection.

Original languageEnglish
Pages (from-to)545-551
Number of pages7
JournalAdvanced Materials
Volume25
Issue number4
DOIs
Publication statusPublished - 2013 Jan 25

Keywords

  • biomedical applications
  • burn therapy
  • nanosheets
  • patchwork
  • poly(L -lactic acid)

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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  • Cite this

    Okamura, Y., Kabata, K., Kinoshita, M., Miyazaki, H., Saito, A., Fujie, T., Ohtsubo, S., Saitoh, D., & Takeoka, S. (2013). Fragmentation of Poly(lactic acid) nanosheets and patchwork treatment for burn wounds. Advanced Materials, 25(4), 545-551. https://doi.org/10.1002/adma.201202851