Fragmentation of Poly(lactic acid) nanosheets and patchwork treatment for burn wounds

Yosuke Okamura; Koki Kabata; Manabu Kinoshita; Hiromi Miyazaki; Akihiro Saito; Toshinori Fujie; Shinya Ohtsubo; Daizoh Saitoh; Shinji Takeoka

doi:10.1002/adma.201202851

Fragmentation of Poly(lactic acid) nanosheets and patchwork treatment for burn wounds

Yosuke Okamura^*, Koki Kabata, Manabu Kinoshita, Hiromi Miyazaki, Akihiro Saito, Toshinori Fujie, Shinya Ohtsubo, Daizoh Saitoh, Shinji Takeoka

^*Corresponding author for this work

School of Advanced Science and Engineering

Research output: Contribution to journal › Article › peer-review

60 Citations (Scopus)

Abstract

Freestanding poly(L-lactic acid) (PLLA) nanosheets are mass-produced by a simple combination of a spin-coating-assisted multi-layering process and a peeling technique. The resulting PLLA nanosheets are fragmented by homogenization and then reconstructed into a "patchwork" sheet on various surfaces without any adhesive reagents. The patchwork is shown to offer excellent protection against burn wound infection with Pseudomonas aeruginosa, and may therefore be an alternative to conventional burn therapy for prevention of infection.

Original language	English
Pages (from-to)	545-551
Number of pages	7
Journal	Advanced Materials
Volume	25
Issue number	4
DOIs	https://doi.org/10.1002/adma.201202851
Publication status	Published - 2013 Jan 25

Keywords

biomedical applications
burn therapy
nanosheets
patchwork
poly(L -lactic acid)

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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10.1002/adma.201202851

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abstract = "Freestanding poly(L-lactic acid) (PLLA) nanosheets are mass-produced by a simple combination of a spin-coating-assisted multi-layering process and a peeling technique. The resulting PLLA nanosheets are fragmented by homogenization and then reconstructed into a {"}patchwork{"} sheet on various surfaces without any adhesive reagents. The patchwork is shown to offer excellent protection against burn wound infection with Pseudomonas aeruginosa, and may therefore be an alternative to conventional burn therapy for prevention of infection.",

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AU - Okamura, Yosuke

AU - Kabata, Koki

AU - Kinoshita, Manabu

AU - Miyazaki, Hiromi

AU - Saito, Akihiro

AU - Fujie, Toshinori

AU - Ohtsubo, Shinya

AU - Saitoh, Daizoh

AU - Takeoka, Shinji

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Y1 - 2013/1/25

N2 - Freestanding poly(L-lactic acid) (PLLA) nanosheets are mass-produced by a simple combination of a spin-coating-assisted multi-layering process and a peeling technique. The resulting PLLA nanosheets are fragmented by homogenization and then reconstructed into a "patchwork" sheet on various surfaces without any adhesive reagents. The patchwork is shown to offer excellent protection against burn wound infection with Pseudomonas aeruginosa, and may therefore be an alternative to conventional burn therapy for prevention of infection.

AB - Freestanding poly(L-lactic acid) (PLLA) nanosheets are mass-produced by a simple combination of a spin-coating-assisted multi-layering process and a peeling technique. The resulting PLLA nanosheets are fragmented by homogenization and then reconstructed into a "patchwork" sheet on various surfaces without any adhesive reagents. The patchwork is shown to offer excellent protection against burn wound infection with Pseudomonas aeruginosa, and may therefore be an alternative to conventional burn therapy for prevention of infection.

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KW - poly(L -lactic acid)

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Fragmentation of Poly(lactic acid) nanosheets and patchwork treatment for burn wounds

Abstract

Keywords

ASJC Scopus subject areas

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