From meiosis to postmeiotic events: Uncovering the molecular roles of the meiosis-specific recombinase Dmc1

Wataru Kagawa, Hitoshi Kurumizaka

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    25 Citations (Scopus)

    Abstract

    In meiosis, the accurate segregation of maternal and paternal chromosomes is accomplished by homologous recombination. A central player in meiotic recombination is the Dmc1 recombinase, a member of the RecA/Rad51 recombinase superfamily, which is widely conserved from viruses to humans. Dmc1 is a meiosis-specific protein that functions with the ubiquitously expressed homolog, the Rad51 recombinase, which is essential for both mitotic and meiotic recombination. Since its discovery, it has been speculated that Dmc1 is important for unique aspects of meiotic recombination. Understanding the distinctive properties of Dmc1, namely, the features that distinguish it from Rad51, will further clarify the mechanisms of meiotic recombination. Recent structural, biochemical, and genetic findings are now revealing the molecular mechanisms of Dmc1-mediated homologous recombination and its regulation by various recombination mediators.

    Original languageEnglish
    Pages (from-to)590-598
    Number of pages9
    JournalFEBS Journal
    Volume277
    Issue number3
    DOIs
    Publication statusPublished - 2010 Feb

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    Keywords

    • Helical filament
    • Meiotic recombination
    • Octameric ring
    • Recombination regulators

    ASJC Scopus subject areas

    • Biochemistry
    • Cell Biology
    • Molecular Biology

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