F1-ATPase is a highly efficient molecular motor that rotates with discrete 120°steps

Ryohei Yasuda, Hiroyuki Noji, Kazuhiko Kinosita, Masasuke Yoshida

Research output: Contribution to journalArticle

646 Citations (Scopus)

Abstract

A single molecule of F1-ATPase, a portion of ATP synthese, is by itself a rotary motor in which a central γ subunit rotates against a surrounding cylinder made of α3β3 subunits. Driven by three catalytic βs, each fueled with ATP, γ makes discrete 120°steps, occasionally stepping backward. The work done in each step is constant over a broad range of imposed load and is close to the free energy of hydrolysis of one ATP molecule.

Original languageEnglish
Pages (from-to)1117-1124
Number of pages8
JournalCell
Volume93
Issue number7
DOIs
Publication statusPublished - 1998 Jun 26
Externally publishedYes

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Proton-Translocating ATPases
Adenosine Triphosphate
Molecules
Free energy
Hydrolysis

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

F1-ATPase is a highly efficient molecular motor that rotates with discrete 120°steps. / Yasuda, Ryohei; Noji, Hiroyuki; Kinosita, Kazuhiko; Yoshida, Masasuke.

In: Cell, Vol. 93, No. 7, 26.06.1998, p. 1117-1124.

Research output: Contribution to journalArticle

Yasuda, Ryohei ; Noji, Hiroyuki ; Kinosita, Kazuhiko ; Yoshida, Masasuke. / F1-ATPase is a highly efficient molecular motor that rotates with discrete 120°steps. In: Cell. 1998 ; Vol. 93, No. 7. pp. 1117-1124.
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