F1-ATPase is a highly efficient molecular motor that rotates with discrete 120°steps

Ryohei Yasuda; Hiroyuki Noji; Kazuhiko Kinosita; Masasuke Yoshida

doi:10.1016/S0092-8674(00)81456-7

F₁-ATPase is a highly efficient molecular motor that rotates with discrete 120°steps

Ryohei Yasuda^*, Hiroyuki Noji, Kazuhiko Kinosita, Masasuke Yoshida

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

690 Citations (Scopus)

Abstract

A single molecule of F₁-ATPase, a portion of ATP synthese, is by itself a rotary motor in which a central γ subunit rotates against a surrounding cylinder made of α₃β₃ subunits. Driven by three catalytic βs, each fueled with ATP, γ makes discrete 120°steps, occasionally stepping backward. The work done in each step is constant over a broad range of imposed load and is close to the free energy of hydrolysis of one ATP molecule.

Original language	English
Pages (from-to)	1117-1124
Number of pages	8
Journal	Cell
Volume	93
Issue number	7
DOIs	https://doi.org/10.1016/S0092-8674(00)81456-7
Publication status	Published - 1998 Jun 26
Externally published	Yes

ASJC Scopus subject areas

Cell Biology
Molecular Biology

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abstract = "A single molecule of F1-ATPase, a portion of ATP synthese, is by itself a rotary motor in which a central γ subunit rotates against a surrounding cylinder made of α3β3 subunits. Driven by three catalytic βs, each fueled with ATP, γ makes discrete 120°steps, occasionally stepping backward. The work done in each step is constant over a broad range of imposed load and is close to the free energy of hydrolysis of one ATP molecule.",

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AU - Kinosita, Kazuhiko

AU - Yoshida, Masasuke

PY - 1998/6/26

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AB - A single molecule of F1-ATPase, a portion of ATP synthese, is by itself a rotary motor in which a central γ subunit rotates against a surrounding cylinder made of α3β3 subunits. Driven by three catalytic βs, each fueled with ATP, γ makes discrete 120°steps, occasionally stepping backward. The work done in each step is constant over a broad range of imposed load and is close to the free energy of hydrolysis of one ATP molecule.

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F₁-ATPase is a highly efficient molecular motor that rotates with discrete 120°steps

Abstract

ASJC Scopus subject areas

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