Function of insulin in snail brain in associative learning

S. Kojima, H. Sunada, K. Mita, M. Sakakibara, K. Lukowiak, Etsuro Ito

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Insulin is well known as a hormone regulating glucose homeostasis across phyla. Although there are insulin-independent mechanisms for glucose uptake in the mammalian brain, which had contributed to a perception of the brain as an insulin-insensitive organ for decades, the finding of insulin and its receptors in the brain revolutionized the concept of insulin signaling in the brain. However, insulin’s role in brain functions, such as cognition, attention, and memory, remains unknown. Studies using invertebrates with their open blood-vascular system have the promise of promoting a better understanding of the role played by insulin in mediating/modulating cognitive functions. In this review, the relationship between insulin and its impact on long-term memory (LTM) is discussed particularly in snails. The pond snail Lymnaea stagnalis has the ability to undergo conditioned taste aversion (CTA), that is, it associatively learns and forms LTM not to respond with a feeding response to a food that normally elicits a robust feeding response. We show that molluscan insulin-related peptides are up-regulated in snails exhibiting CTA–LTM and play a key role in the causal neural basis of CTA–LTM. We also survey the relevant literature of the roles played by insulin in learning and memory in other phyla.

Original languageEnglish
Pages (from-to)969-981
Number of pages13
JournalJournal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology
Volume201
Issue number10
DOIs
Publication statusPublished - 2015 Oct 23
Externally publishedYes

Fingerprint

Snails
snail
snails
brain
insulin
learning
Learning
Insulin
Brain
glucose
Long-Term Memory
Cognition
cognition
homeostasis
peptide
hormone
Insulins
Lymnaea
Glucose
pond

Keywords

  • Conditioned taste aversion
  • Insulin
  • Long-term memory
  • Lymnaea
  • Synaptic enhancement

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Ecology, Evolution, Behavior and Systematics
  • Physiology
  • Behavioral Neuroscience
  • Medicine(all)

Cite this

Function of insulin in snail brain in associative learning. / Kojima, S.; Sunada, H.; Mita, K.; Sakakibara, M.; Lukowiak, K.; Ito, Etsuro.

In: Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology, Vol. 201, No. 10, 23.10.2015, p. 969-981.

Research output: Contribution to journalReview article

Kojima, S. ; Sunada, H. ; Mita, K. ; Sakakibara, M. ; Lukowiak, K. ; Ito, Etsuro. / Function of insulin in snail brain in associative learning. In: Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology. 2015 ; Vol. 201, No. 10. pp. 969-981.
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