TY - JOUR
T1 - Functional neuroanatomy of human non-rapid eye movement sleep
T2 - A study using a positron emission tomography
AU - Kajimura, Naofumi
AU - Uchiyama, Makoto
AU - Takayama, Yutaka
AU - Uchida, Sunao
AU - Uema, Takeshi
AU - Kato, Masaaki
AU - Sekimoto, Masanori
AU - Watanabe, Tsuyoshi
AU - Nakajima, Toru
AU - Horikoshi, Satoru
AU - Ogawa, Kenichi
AU - Nishikawa, Masami
AU - Hiroki, Masahiko
AU - Kudo, Yoshihisa
AU - Matsuda, Hiroshi
AU - Okawa, Masako
AU - Takahashi, Kiyohisa
PY - 2002/4/1
Y1 - 2002/4/1
N2 - In order to clarify the neural correlates and brain functions during non-rapid eye movement (NREM) sleep, regional cerebral blood flow (rCBF) were measured using positron emission tomography (PET) in healthy male subjects. During light NREM sleep, the rCBF in the midbrain, in contrast to that in the pons and thalamic nuclei, did not decrease when compared to that during wakefulness, while rCBF decreased in the left medial frontal gyrus, left inferior frontal gyrus, and left inferior parietal gyrus of the neocortex. During deep NREM sleep, the rCBF in the midbrain tegmentum decreased and there was a marked and bilateral decrease in the rCBF in all neocortical regions except for the peri-rolandic areas and the occipital lobe. Thus, the activity of the midbrain reticular formation may be maintained during light NREM sleep. Furthermore, selective deactivation of heteromodal association cortices including those related to language, may occur during NREM sleep, which supports the recent theory that sleep is a local, use-dependent process of the brain.
AB - In order to clarify the neural correlates and brain functions during non-rapid eye movement (NREM) sleep, regional cerebral blood flow (rCBF) were measured using positron emission tomography (PET) in healthy male subjects. During light NREM sleep, the rCBF in the midbrain, in contrast to that in the pons and thalamic nuclei, did not decrease when compared to that during wakefulness, while rCBF decreased in the left medial frontal gyrus, left inferior frontal gyrus, and left inferior parietal gyrus of the neocortex. During deep NREM sleep, the rCBF in the midbrain tegmentum decreased and there was a marked and bilateral decrease in the rCBF in all neocortical regions except for the peri-rolandic areas and the occipital lobe. Thus, the activity of the midbrain reticular formation may be maintained during light NREM sleep. Furthermore, selective deactivation of heteromodal association cortices including those related to language, may occur during NREM sleep, which supports the recent theory that sleep is a local, use-dependent process of the brain.
KW - Midbrain reticular formation
KW - NREM sleep
KW - PET
KW - Polysomnography
KW - rCBF
UR - http://www.scopus.com/inward/record.url?scp=68849089606&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=68849089606&partnerID=8YFLogxK
U2 - 10.1016/S0531-5131(02)00148-6
DO - 10.1016/S0531-5131(02)00148-6
M3 - Article
AN - SCOPUS:68849089606
SN - 0531-5131
VL - 1232
SP - 801
EP - 805
JO - International Congress Series
JF - International Congress Series
IS - C
ER -