Functional plasticity of language confirmed with intraoperative electrical stimulations and updated neuronavigation: Case report of low-grade glioma of the left inferior frontal gyrus

Taiichi Saito, Yoshihiro Muragaki, Isamu Miura, Manabu Tamura, Takashi Maruyama, Masayuki Nitta, Kaoru Kurisu, Hiroshi Iseki, Yoshikazu Okada

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Removal of glioma from the dominant side of the inferior frontal gyrus (IFG) is associated with a risk of permanent language dysfunction. While intraoperative cortical and subcortical electrical stimulations can be used for functional language mapping in an effort to reduce the risk of postoperative neurological impairment, the extent of resection is limited by the functional boundaries. Recent reports proposed that a two-stage surgical approach for low-grade glioma in eloquent areas could avoid permanent deficits via the functional plasticity that occurs between the two operations. The report describes a patient with World Health Organization (WHO) grade II oligoastrocytoma in the left IFG, in functional plasticity of language occurred in the interval between two consecutive surgeries. Intraoperative electrical stimulations suggested that a language area and related subcortical fiber crossed the pre-central sulcus during tumor progression owing to functional plasticity. In the present case, we integrated neurophysiological data into the intraoperative neuronavigation system. We also confirmed the peri-lesional shift of language area and related subcortical fiber on image findings. Consequently, the tumor was sub-totally removed with two separate resections. Permanent language disturbance did not occur, and this favorable outcome was attributed to functional plasticity. The present experience sustains the multistage approach for lowgrade gliomas in the language area. A combination of intraoperative electrical stimulations and updated neuronavigation may facilitate the characterization of brain functional plasticity.

Original languageEnglish
Pages (from-to)587-592
Number of pages6
JournalNeurologia Medico-Chirurgica
Volume54
Issue number7
DOIs
Publication statusPublished - 2014 Jul 15
Externally publishedYes

Fingerprint

Neuronavigation
Prefrontal Cortex
Glioma
Electric Stimulation
Language
Neoplasms
Brain

Keywords

  • Cortical mapping
  • Intraoperative magnetic resonance imaging
  • Low-grade glioma
  • Plasticity
  • Updated neuronavigation

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Functional plasticity of language confirmed with intraoperative electrical stimulations and updated neuronavigation : Case report of low-grade glioma of the left inferior frontal gyrus. / Saito, Taiichi; Muragaki, Yoshihiro; Miura, Isamu; Tamura, Manabu; Maruyama, Takashi; Nitta, Masayuki; Kurisu, Kaoru; Iseki, Hiroshi; Okada, Yoshikazu.

In: Neurologia Medico-Chirurgica, Vol. 54, No. 7, 15.07.2014, p. 587-592.

Research output: Contribution to journalArticle

Saito, Taiichi ; Muragaki, Yoshihiro ; Miura, Isamu ; Tamura, Manabu ; Maruyama, Takashi ; Nitta, Masayuki ; Kurisu, Kaoru ; Iseki, Hiroshi ; Okada, Yoshikazu. / Functional plasticity of language confirmed with intraoperative electrical stimulations and updated neuronavigation : Case report of low-grade glioma of the left inferior frontal gyrus. In: Neurologia Medico-Chirurgica. 2014 ; Vol. 54, No. 7. pp. 587-592.
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