Functionalized BINOL-mono-PHOS for multinuclear Cu-catalysts in asymmetric conjugate addition of organozinc reagents

Kohei Endo, Sayuri Yakeishi, Daisuke Hamada, Takanori Shibata

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Abstract

    Functionalization of BINOL-mono-PHOS achieved the Cucatalyzed highly asymmetric conjugate addition of organozinc reagents to enones. The incorporation of a bulky hydroxy group at the 3'-position of BINOL-mono-PHOS dramatically improved the yield and enantioselectivity. The present novel BINOL-mono-PHOS ligands are effective in the Cu-catalyzed asymmetric conjugate addition of organozinc reagents in both acyclic enones and cyclohexenone.

    Original languageEnglish
    Pages (from-to)547-549
    Number of pages3
    JournalChemistry Letters
    Volume42
    Issue number5
    DOIs
    Publication statusPublished - 2013

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    Catalysts
    Enantioselectivity
    Ligands
    naphthol BINOL

    ASJC Scopus subject areas

    • Chemistry(all)

    Cite this

    Functionalized BINOL-mono-PHOS for multinuclear Cu-catalysts in asymmetric conjugate addition of organozinc reagents. / Endo, Kohei; Yakeishi, Sayuri; Hamada, Daisuke; Shibata, Takanori.

    In: Chemistry Letters, Vol. 42, No. 5, 2013, p. 547-549.

    Research output: Contribution to journalArticle

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    AU - Shibata, Takanori

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