Functionalized BINOL-mono-PHOS for multinuclear Cu-catalysts in asymmetric conjugate addition of organozinc reagents

Kohei Endo; Sayuri Yakeishi; Daisuke Hamada; Takanori Shibata

doi:10.1246/cl.130080

Functionalized BINOL-mono-PHOS for multinuclear Cu-catalysts in asymmetric conjugate addition of organozinc reagents

Kohei Endo, Sayuri Yakeishi, Daisuke Hamada, Takanori Shibata

School of Advanced Science and Engineering

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Functionalization of BINOL-mono-PHOS achieved the Cucatalyzed highly asymmetric conjugate addition of organozinc reagents to enones. The incorporation of a bulky hydroxy group at the 3'-position of BINOL-mono-PHOS dramatically improved the yield and enantioselectivity. The present novel BINOL-mono-PHOS ligands are effective in the Cu-catalyzed asymmetric conjugate addition of organozinc reagents in both acyclic enones and cyclohexenone.

Original language	English
Pages (from-to)	547-549
Number of pages	3
Journal	Chemistry Letters
Volume	42
Issue number	5
DOIs	https://doi.org/10.1246/cl.130080
Publication status	Published - 2013 May 15

ASJC Scopus subject areas

Chemistry(all)

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10.1246/cl.130080

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abstract = "Functionalization of BINOL-mono-PHOS achieved the Cucatalyzed highly asymmetric conjugate addition of organozinc reagents to enones. The incorporation of a bulky hydroxy group at the 3'-position of BINOL-mono-PHOS dramatically improved the yield and enantioselectivity. The present novel BINOL-mono-PHOS ligands are effective in the Cu-catalyzed asymmetric conjugate addition of organozinc reagents in both acyclic enones and cyclohexenone.",

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T1 - Functionalized BINOL-mono-PHOS for multinuclear Cu-catalysts in asymmetric conjugate addition of organozinc reagents

AU - Endo, Kohei

AU - Yakeishi, Sayuri

AU - Hamada, Daisuke

AU - Shibata, Takanori

PY - 2013/5/15

Y1 - 2013/5/15

N2 - Functionalization of BINOL-mono-PHOS achieved the Cucatalyzed highly asymmetric conjugate addition of organozinc reagents to enones. The incorporation of a bulky hydroxy group at the 3'-position of BINOL-mono-PHOS dramatically improved the yield and enantioselectivity. The present novel BINOL-mono-PHOS ligands are effective in the Cu-catalyzed asymmetric conjugate addition of organozinc reagents in both acyclic enones and cyclohexenone.

AB - Functionalization of BINOL-mono-PHOS achieved the Cucatalyzed highly asymmetric conjugate addition of organozinc reagents to enones. The incorporation of a bulky hydroxy group at the 3'-position of BINOL-mono-PHOS dramatically improved the yield and enantioselectivity. The present novel BINOL-mono-PHOS ligands are effective in the Cu-catalyzed asymmetric conjugate addition of organozinc reagents in both acyclic enones and cyclohexenone.

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Functionalized BINOL-mono-PHOS for multinuclear Cu-catalysts in asymmetric conjugate addition of organozinc reagents

Abstract

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