Functionalized BINOL-mono-PHOS for multinuclear Cu-catalysts in asymmetric conjugate addition of organozinc reagents

Kohei Endo, Sayuri Yakeishi, Daisuke Hamada, Takanori Shibata

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Abstract

Functionalization of BINOL-mono-PHOS achieved the Cucatalyzed highly asymmetric conjugate addition of organozinc reagents to enones. The incorporation of a bulky hydroxy group at the 3'-position of BINOL-mono-PHOS dramatically improved the yield and enantioselectivity. The present novel BINOL-mono-PHOS ligands are effective in the Cu-catalyzed asymmetric conjugate addition of organozinc reagents in both acyclic enones and cyclohexenone.

Original languageEnglish
Pages (from-to)547-549
Number of pages3
JournalChemistry Letters
Volume42
Issue number5
DOIs
Publication statusPublished - 2013 May 15

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ASJC Scopus subject areas

  • Chemistry(all)

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