Genome sequence of the cat pathogen, Chlamydophila felis

Yoshinao Azuma, Hideki Hirakawa, Atsushi Yamashita, Yan Cai, Mohd Akhlakur Rahman, Harumi Suzuki, Shigeki Mitaku, Hidehiro Toh, Susumu Goto, Tomoyuki Murakami, Kazuro Sugi, Hideo Hayashi, Hideto Fukushi, Masahira Hattori, Satoru Kuhara, Mutsunori Shirai

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Chlamydophila felis (Chlamydia psittaci feline pneumonitis agent) is a worldwide spread pathogen for pneumonia and conjunctivitis in cats. Herein, we determined the entire genomic DNA sequence of the Japanese C. felis strain Fe/C-56 to understand the mechanism of diseases caused by this pathogen. The C. felis genome is composed of a circular 1 166 239 bp chromosome encoding 1005 protein-coding genes and a 7552 bp circular plasmid. Comparison of C. felis gene contents with other Chlamydia species shows that 795 genes are common in the family Chlamydiaceae species and 47 genes are specific to C. felis. Phylogenetic analysis of the common genes reveals that most of the orthologue sets exhibit a similar divergent pattern but 14 C. felis genes accumulate more mutations, implicating that these genes may be involved in the evolutional adaptation to the C. felis-specific niche. Gene distribution and orthologue analyses reveal that two distinctive regions, i.e. the plasticity zone and frequently gene-translocated regions (FGRs), may play important but different roles for chlamydial genome evolution. The genomic DNA sequence of C. felis provides information for comprehension of diseases and elucidation of the chlamydial evolution.

Original languageEnglish
Pages (from-to)15-23
Number of pages9
JournalDNA Research
Volume13
Issue number1
DOIs
Publication statusPublished - 2006
Externally publishedYes

Fingerprint

Chlamydophila
Felis
Cats
Genome
Genes
Chlamydiaceae
Pneumonia
Chlamydophila psittaci
Conjunctivitis
Chlamydia
Felidae
Plasmids
Chromosomes

Keywords

  • Chlamydia
  • Comparative genomics
  • Genome inversion
  • Infectious disease
  • Obligate intercellular bacteria

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology

Cite this

Azuma, Y., Hirakawa, H., Yamashita, A., Cai, Y., Rahman, M. A., Suzuki, H., ... Shirai, M. (2006). Genome sequence of the cat pathogen, Chlamydophila felis. DNA Research, 13(1), 15-23. https://doi.org/10.1093/dnares/dsi027

Genome sequence of the cat pathogen, Chlamydophila felis. / Azuma, Yoshinao; Hirakawa, Hideki; Yamashita, Atsushi; Cai, Yan; Rahman, Mohd Akhlakur; Suzuki, Harumi; Mitaku, Shigeki; Toh, Hidehiro; Goto, Susumu; Murakami, Tomoyuki; Sugi, Kazuro; Hayashi, Hideo; Fukushi, Hideto; Hattori, Masahira; Kuhara, Satoru; Shirai, Mutsunori.

In: DNA Research, Vol. 13, No. 1, 2006, p. 15-23.

Research output: Contribution to journalArticle

Azuma, Y, Hirakawa, H, Yamashita, A, Cai, Y, Rahman, MA, Suzuki, H, Mitaku, S, Toh, H, Goto, S, Murakami, T, Sugi, K, Hayashi, H, Fukushi, H, Hattori, M, Kuhara, S & Shirai, M 2006, 'Genome sequence of the cat pathogen, Chlamydophila felis', DNA Research, vol. 13, no. 1, pp. 15-23. https://doi.org/10.1093/dnares/dsi027
Azuma Y, Hirakawa H, Yamashita A, Cai Y, Rahman MA, Suzuki H et al. Genome sequence of the cat pathogen, Chlamydophila felis. DNA Research. 2006;13(1):15-23. https://doi.org/10.1093/dnares/dsi027
Azuma, Yoshinao ; Hirakawa, Hideki ; Yamashita, Atsushi ; Cai, Yan ; Rahman, Mohd Akhlakur ; Suzuki, Harumi ; Mitaku, Shigeki ; Toh, Hidehiro ; Goto, Susumu ; Murakami, Tomoyuki ; Sugi, Kazuro ; Hayashi, Hideo ; Fukushi, Hideto ; Hattori, Masahira ; Kuhara, Satoru ; Shirai, Mutsunori. / Genome sequence of the cat pathogen, Chlamydophila felis. In: DNA Research. 2006 ; Vol. 13, No. 1. pp. 15-23.
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