Genome sequence of the tsetse fly (Glossina morsitans ): Vector of African trypanosomiasis

Junichi Watanabe, Masahira Hattori, Matthew Berriman, Michael J. Lehane, Neil Hall, Philippe Solano, Serap Aksoy, Winston Hide, Yeya Touré, Geoffrey M. Attardo, Alistair C. Darby, Atsushi Toyoda, Christiane Hertz-Fowler, Denis M. Larkin, James A. Cotton, Mandy J. Sanders, Martin T. Swain, Michael A. Quail, Noboru Inoue, Sophie RavelTodd D. Taylor, Tulika P. Srivastava, Vineet Sharma, Wesley Warren, Richard K. Wilson, Yutaka Suzuki, Daniel Lawson, Daniel S T Hughes, Karyn Megy, Daniel K. Masiga, Paul O. Mireji, Immo A. Hansen, Jan Van Den Abbeele, Joshua B. Benoit, Kostas Bourtzis, George F O Obiero, Hugh M. Robertson, Jeffery W. Jones, Jing Jiang Zhou, Linda M. Field, Markus Friedrich, Steven R G Nyanjom, Erich L. Telleria, Guy Caljon, José M C Ribeiro, Alvaro Acosta-Serrano, Cher Pheng Ooi, Clair Rose, David P. Price, Lee R. Haines, Alan Christoffels, Cheolho Sim, Daphne Q D Pham, David L. Denlinger, Dawn L. Geiser, Irene A. Omedo, Joy J. Winzerling, Justin T. Peyton, Kevin K. Marucha, Mario Jonas, Megan E. Meuti, Neil D. Rawlings, Qirui Zhang, Rosaline W. Macharia, Veronika Michalkova, Zahra Jalali Sefid Dashti, Aaron A. Baumann, Gerd Gäde, Heather G. Marco, Jelle Caers, Liliane Schoofs, Michael A. Riehle, Wanqi Hu, Zhijian Tu, Aaron M. Tarone, Anna R. Malacrida, Caleb K. Kibet, Francesca Scolari, Jacobus J O Koekemoer, Judith Willis, Ludvik M. Gomulski, Marco Falchetto, Maxwell J. Scott, Shuhua Fu, Sing Hoi Sze, Thiago Luiz, Brian Weiss, Deirdre P. Walshe, Jingwen Wang, Mark Wamalwa, Sarah Mwangi, Urvashi N. Ramphul, Anna K. Snyder, Corey L. Brelsfoard, Gavin H. Thomas, George Tsiamis, Peter Arensburger, Rita V M Rio, Sandy J. Macdonald, Sumir Panji, Adele Kruger, Alia Benkahla, Apollo S P Balyeidhusa, Atway Msangi, Chinyere K. Okoro, Dawn Stephens, Eleanor J. Stanley, Feziwe Mpondo, Florence Wamwiri, Furaha Mramba, Geoffrey Siwo, George Githinji, Gordon Harkins, Grace Murilla, Heikki Lehväslaiho, Imna Malele, Joanna E. Auma, Johnson K. Kinyua, Johnson Ouma, Loyce Okedi, Lucien Manga, Martin Aslett, Mathurin Koffi, Michael W. Gaunt, Mmule Makgamathe, Nicola Mulder, Oliver Manangwa, Patrick P. Abila, Patrick Wincker, Richard Gregory, Rosemary Bateta, Ryuichi Sakate, Sheila Ommeh, Stella Lehane, Tadashi Imanishi, Victor C. Osamor, Yoshihiro Kawahara

Research output: Contribution to journalArticle

132 Citations (Scopus)

Abstract

Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation of the 366-megabase Glossina morsitans morsitans genome. Analysis of the genome and the 12,308 predicted protein-encoding genes led to multiple discoveries, including chromosomal integrations of bacterial (Wolbachia) genome sequences, a family of lactation-specific proteins, reduced complement of host pathogen recognition proteins, and reduced olfaction/chemosensory associated genes. These genome data provide a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology.

Original languageEnglish
Pages (from-to)380-386
Number of pages7
JournalScience
Volume344
Issue number6182
DOIs
Publication statusPublished - 2014
Externally publishedYes

ASJC Scopus subject areas

  • General
  • History and Philosophy of Science

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    Watanabe, J., Hattori, M., Berriman, M., Lehane, M. J., Hall, N., Solano, P., Aksoy, S., Hide, W., Touré, Y., Attardo, G. M., Darby, A. C., Toyoda, A., Hertz-Fowler, C., Larkin, D. M., Cotton, J. A., Sanders, M. J., Swain, M. T., Quail, M. A., Inoue, N., ... Kawahara, Y. (2014). Genome sequence of the tsetse fly (Glossina morsitans ): Vector of African trypanosomiasis. Science, 344(6182), 380-386. https://doi.org/10.1126/science.1249656