Glucose ingestion inhibits endurance exercise-induced IL-6 producing macrophage infiltration in mice muscle

Takaki Tominaga, Sihui Ma, Kumiko Saitou, Katsuhiko Suzuki

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Background: Carbohydrate (CHO) supplementation during exercise attenuates exercise-induced increases in plasma Interleukin (IL)-6 concentration. However, the effects of CHO supplementation on muscle IL-6 production during endurance exercise is controversial. The purpose of this study was to investigate the effects of CHO supplementation on muscle IL-6 production during endurance exercise with a special focus on the IL-6 producing cells. Methods: C57BL/6J mice were divided into three groups—sedentary with water ingestion group as the control (Con; n = 10), exercise with water ingestion group (Ex; n = 10), and exercise with 6% glucose ingestion group (Ex + glucose; n = 10). The Ex and Ex + glucose groups completed 3 h of treadmill running (24 m/min, 7% incline) and were sacrificed immediately after exercise. Results: The exercise-induced increases of plasma IL-6 concentration and gastrocnemius IL-6 gene expression were attenuated by glucose ingestion. However, the increases of soleus IL-6 gene expression and gastrocnemius and soleus IL-6 protein expression were not attenuated by glucose ingestion. Furthermore, we observed that macrophages that infiltrated muscle produce IL-6 and glucose ingestion attenuated the infiltration of IL-6-producing macrophages. Conclusion: This study revealed that infiltrating macrophages may be one type of IL-6-producing cells during endurance exercise, and the infiltration of these cells in muscle was attenuated by glucose ingestion. However, the effects of glucose ingestion on muscle IL-6 production were limited.

Original languageEnglish
Article number1496
JournalNutrients
Volume11
Issue number7
DOIs
Publication statusPublished - 2019 Jul

Keywords

  • Endurance exercise
  • Glucose ingestion
  • Interleukin 6 (IL-6)
  • Macrophage
  • Monocyte chemotactic protein (MCP)-1

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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