Gonadotrophin-inhibitory hormone: A multifunctional neuropeptide

George E. Bentley, T. Ubuka, N. L. Mcguire, R. Calisi, N. Perfito, L. J. Kriegsfeld, J. C. Wingfield, Kazuyoshi Tsutsui

    Research output: Contribution to journalArticle

    40 Citations (Scopus)

    Abstract

    Gonadotrophin-inhibitory hormone (GnIH) was discovered 8 years ago in birds. Its identification raised the possibility that gonadotrophin-releasing hormone (GnRH) is not the sole hypothalamic neuropeptide that directly influences pituitary gonadotrophin release. Initial studies on GnIH focused on the avian anterior pituitary as comprising the only physiological target of GnIH. There are now several lines of evidence indicating that GnIH directly inhibits pituitary gonadotrophin synthesis and release in birds and mammals. Histological studies on projections from hypothalamic GnIH neurones subsequently implied direct actions of GnIH within the brain and in the periphery. In addition to actions on the pars distalis via the median eminence, GnIH axons and terminals are present in multiple brain areas in birds, and the GnIH receptor is expressed on GnRH-I and -II neurones. Furthermore, we have demonstrated the presence of GnIH and its receptor in avian and mammalian gonads. Thus, GnIH can act directly at multiple levels: within the brain, on the pituitary and in the gonads. In sum, our data indicate that GnIH and its related peptides are important modulators of reproductive function at the level of the GnRH neurone, the gonadotroph and the gonads. Here, we provide an overview of the known levels of GnIH action in birds and mammals. In addition, environmental and physiological factors that are involved in GnIH regulation are reviewed.

    Original languageEnglish
    Pages (from-to)276-281
    Number of pages6
    JournalJournal of Neuroendocrinology
    Volume21
    Issue number4
    DOIs
    Publication statusPublished - 2009

    Fingerprint

    Neuropeptides
    Gonadotropins
    Hormones
    Birds
    Gonads
    Gonadotropin-Releasing Hormone
    Pituitary Gonadotropins
    Neurons
    Mammals
    Brain
    Gonadotrophs
    Median Eminence
    Presynaptic Terminals

    Keywords

    • GnRH
    • HPG axis
    • Melatonin
    • RFamide
    • Seasonal breeding

    ASJC Scopus subject areas

    • Endocrinology
    • Endocrinology, Diabetes and Metabolism
    • Endocrine and Autonomic Systems
    • Cellular and Molecular Neuroscience

    Cite this

    Bentley, G. E., Ubuka, T., Mcguire, N. L., Calisi, R., Perfito, N., Kriegsfeld, L. J., ... Tsutsui, K. (2009). Gonadotrophin-inhibitory hormone: A multifunctional neuropeptide. Journal of Neuroendocrinology, 21(4), 276-281. https://doi.org/10.1111/j.1365-2826.2009.01851.x

    Gonadotrophin-inhibitory hormone : A multifunctional neuropeptide. / Bentley, George E.; Ubuka, T.; Mcguire, N. L.; Calisi, R.; Perfito, N.; Kriegsfeld, L. J.; Wingfield, J. C.; Tsutsui, Kazuyoshi.

    In: Journal of Neuroendocrinology, Vol. 21, No. 4, 2009, p. 276-281.

    Research output: Contribution to journalArticle

    Bentley, GE, Ubuka, T, Mcguire, NL, Calisi, R, Perfito, N, Kriegsfeld, LJ, Wingfield, JC & Tsutsui, K 2009, 'Gonadotrophin-inhibitory hormone: A multifunctional neuropeptide', Journal of Neuroendocrinology, vol. 21, no. 4, pp. 276-281. https://doi.org/10.1111/j.1365-2826.2009.01851.x
    Bentley GE, Ubuka T, Mcguire NL, Calisi R, Perfito N, Kriegsfeld LJ et al. Gonadotrophin-inhibitory hormone: A multifunctional neuropeptide. Journal of Neuroendocrinology. 2009;21(4):276-281. https://doi.org/10.1111/j.1365-2826.2009.01851.x
    Bentley, George E. ; Ubuka, T. ; Mcguire, N. L. ; Calisi, R. ; Perfito, N. ; Kriegsfeld, L. J. ; Wingfield, J. C. ; Tsutsui, Kazuyoshi. / Gonadotrophin-inhibitory hormone : A multifunctional neuropeptide. In: Journal of Neuroendocrinology. 2009 ; Vol. 21, No. 4. pp. 276-281.
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