Gonadotrophin-inhibitory hormone and its mammalian orthologue RFamide-related peptide-3: Discovery and functional implications for reproduction and stress

L. J. Kriegsfeld, K. J. Jennings, G. E. Bentley, Kazuyoshi Tsutsui

    Research output: Contribution to journalReview article

    6 Citations (Scopus)

    Abstract

    At the turn of the millennium, a neuropeptide with pronounced inhibitory actions on avian pituitary gonadotrophin secretion was identified and named gonadotrophin-inhibitory hormone (GnIH). Across bird species, GnIH acts at the level of the pituitary and the gonadotrophin-releasing hormone (GnRH) neuronal system to inhibit reproduction. Subsequent to this initial discovery, orthologues of GnIH have been identified and characterised across a broad range of species. In many vertebrates, the actions of GnIH and its orthologues serve functional roles analogous to those seen in birds. In other cases, GnIH and its orthologues exhibit more diverse actions dependent on sex, species, season and reproductive condition. The present review highlights the discovery and functional implications of GnIH across species, focusing on research domains in which the significance of this neuropeptide has been explored most.

    Original languageEnglish
    Article numbere12597
    JournalJournal of Neuroendocrinology
    Volume30
    Issue number7
    DOIs
    Publication statusPublished - 2018 Jul 1

    Fingerprint

    Gonadotropins
    Reproduction
    Hormones
    Pituitary Gonadotropins
    Neuropeptides
    Birds
    Gonadotropin-Releasing Hormone
    Vertebrates
    RFamide peptide
    Research

    Keywords

    • GnIH
    • reproduction
    • RFamide
    • RFRP

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism
    • Endocrinology
    • Endocrine and Autonomic Systems
    • Cellular and Molecular Neuroscience

    Cite this

    Gonadotrophin-inhibitory hormone and its mammalian orthologue RFamide-related peptide-3 : Discovery and functional implications for reproduction and stress. / Kriegsfeld, L. J.; Jennings, K. J.; Bentley, G. E.; Tsutsui, Kazuyoshi.

    In: Journal of Neuroendocrinology, Vol. 30, No. 7, e12597, 01.07.2018.

    Research output: Contribution to journalReview article

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