Abstract
At the turn of the millennium, a neuropeptide with pronounced inhibitory actions on avian pituitary gonadotrophin secretion was identified and named gonadotrophin-inhibitory hormone (GnIH). Across bird species, GnIH acts at the level of the pituitary and the gonadotrophin-releasing hormone (GnRH) neuronal system to inhibit reproduction. Subsequent to this initial discovery, orthologues of GnIH have been identified and characterised across a broad range of species. In many vertebrates, the actions of GnIH and its orthologues serve functional roles analogous to those seen in birds. In other cases, GnIH and its orthologues exhibit more diverse actions dependent on sex, species, season and reproductive condition. The present review highlights the discovery and functional implications of GnIH across species, focusing on research domains in which the significance of this neuropeptide has been explored most.
| Original language | English |
|---|---|
| Article number | e12597 |
| Journal | Journal of Neuroendocrinology |
| Volume | 30 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2018 Jul 1 |
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Keywords
- GnIH
- reproduction
- RFamide
- RFRP
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology
- Endocrine and Autonomic Systems
- Cellular and Molecular Neuroscience
Cite this
Gonadotrophin-inhibitory hormone and its mammalian orthologue RFamide-related peptide-3 : Discovery and functional implications for reproduction and stress. / Kriegsfeld, L. J.; Jennings, K. J.; Bentley, G. E.; Tsutsui, Kazuyoshi.
In: Journal of Neuroendocrinology, Vol. 30, No. 7, e12597, 01.07.2018.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Gonadotrophin-inhibitory hormone and its mammalian orthologue RFamide-related peptide-3
T2 - Discovery and functional implications for reproduction and stress
AU - Kriegsfeld, L. J.
AU - Jennings, K. J.
AU - Bentley, G. E.
AU - Tsutsui, Kazuyoshi
PY - 2018/7/1
Y1 - 2018/7/1
N2 - At the turn of the millennium, a neuropeptide with pronounced inhibitory actions on avian pituitary gonadotrophin secretion was identified and named gonadotrophin-inhibitory hormone (GnIH). Across bird species, GnIH acts at the level of the pituitary and the gonadotrophin-releasing hormone (GnRH) neuronal system to inhibit reproduction. Subsequent to this initial discovery, orthologues of GnIH have been identified and characterised across a broad range of species. In many vertebrates, the actions of GnIH and its orthologues serve functional roles analogous to those seen in birds. In other cases, GnIH and its orthologues exhibit more diverse actions dependent on sex, species, season and reproductive condition. The present review highlights the discovery and functional implications of GnIH across species, focusing on research domains in which the significance of this neuropeptide has been explored most.
AB - At the turn of the millennium, a neuropeptide with pronounced inhibitory actions on avian pituitary gonadotrophin secretion was identified and named gonadotrophin-inhibitory hormone (GnIH). Across bird species, GnIH acts at the level of the pituitary and the gonadotrophin-releasing hormone (GnRH) neuronal system to inhibit reproduction. Subsequent to this initial discovery, orthologues of GnIH have been identified and characterised across a broad range of species. In many vertebrates, the actions of GnIH and its orthologues serve functional roles analogous to those seen in birds. In other cases, GnIH and its orthologues exhibit more diverse actions dependent on sex, species, season and reproductive condition. The present review highlights the discovery and functional implications of GnIH across species, focusing on research domains in which the significance of this neuropeptide has been explored most.
KW - GnIH
KW - reproduction
KW - RFamide
KW - RFRP
UR - http://www.scopus.com/inward/record.url?scp=85049803705&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85049803705&partnerID=8YFLogxK
U2 - 10.1111/jne.12597
DO - 10.1111/jne.12597
M3 - Review article
C2 - 29624758
AN - SCOPUS:85049803705
VL - 30
JO - Journal of Neuroendocrinology
JF - Journal of Neuroendocrinology
SN - 0953-8194
IS - 7
M1 - e12597
ER -