Gonadotrophin inhibitory hormone depresses gonadotrophin α and follicle-stimulating hormone β subunit expression in the pituitary of the domestic chicken

Nick A. Ciccone, I. C. Dunn, T. Boswell, Kazuyoshi Tsutsui, T. Ubuka, K. Ukena, P. J. Sharp

Research output: Contribution to journalArticle

137 Citations (Scopus)

Abstract

Studies performed in vitro suggest that a novel 12 amino acid RF amide peptide, isolated from the quail hypothalamus, is a gonadotrophin inhibitory hormone (GnIH). The aim of the present study was to investigate this hypothesis in the domestic chicken. Injections of GnIH into nest-deprived incubating hens failed to depress the concentration of plasma luteinizing hormone (LH). Addition of GnIH to short-term (120 min) cultures of diced pituitary glands from adult cockerels depressed follicle-stimulating hormone (FSH) and LH release and depressed common α and FSHβ gonadotrophin subunit mRNAs, with no effect on LHβ subunit mRNA. Hypothalamic GnIH mRNA was higher in incubating (out-of-lay) than in laying hens, but there was no significant difference in the amount of hypothalamic GnIH mRNA in out-of-lay and laying broiler breeder hens at the end of a laying year. It is concluded that avian GnIH may play a role in controlling gonadotrophin synthesis and associated constitutive release in the domestic chicken.

Original languageEnglish
Pages (from-to)999-1006
Number of pages8
JournalJournal of Neuroendocrinology
Volume16
Issue number12
DOIs
Publication statusPublished - 2004 Dec
Externally publishedYes

Fingerprint

Follicle Stimulating Hormone
Gonadotropins
Chickens
Hormones
Luteinizing Hormone
Messenger RNA
Quail
Pituitary Gland
Amides
Hypothalamus
Amino Acids
Peptides
Injections

Keywords

  • Chicken
  • GnlH
  • Gonadotrophin mRNAs
  • Hypothalamus
  • Reproduction

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)

Cite this

Gonadotrophin inhibitory hormone depresses gonadotrophin α and follicle-stimulating hormone β subunit expression in the pituitary of the domestic chicken. / Ciccone, Nick A.; Dunn, I. C.; Boswell, T.; Tsutsui, Kazuyoshi; Ubuka, T.; Ukena, K.; Sharp, P. J.

In: Journal of Neuroendocrinology, Vol. 16, No. 12, 12.2004, p. 999-1006.

Research output: Contribution to journalArticle

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