Gonadotropin-inhibiting hormone stimulates feeding behavior in chicks

Tetsuya Tachibana, Momoka Sato, Hirokazu Takahashi, Kazuyoshi Ukena, Kazuyoshi Tsutsui, Mitsuhiro Furuse

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

Neuropeptides containing a C-terminal Arg-Phe-NH2 motif (RFamide peptides) are suggested to be involved in the control of feeding behavior in both invertebrates and vertebrates. Gonadotropin-inhibitory hormone (GnIH) is the first identified avian RFamide peptide that inhibits gonadotropin release from the pituitary. The GnIH precursor encodes one GnIH and its related peptides (GnIH-RP-1 and -RP-2) that shared the same C-terminal motif, Leu-Pro-Xaa-Arg-Phe-NH2 (Xaa = Leu or Gln) (LPXRFamide). GnIH neurons are localized in the paraventricular nucleus, with their fibers visible in multiple brain locations including the median eminence and brainstem. In this study, we therefore investigated the action of GnIH and its related peptides on feeding behavior. Intracerebroventricular (ICV) injection of GnIH, GnIH-RP-1 and GnIH-RP-2 significantly stimulated food intake in chicks. The chicken pentapeptide LPLRFamide, a degraded C-terminus of GnIH and GnIH-RP-1, did not stimulate feeding thereby demonstrating the importance of the N-terminus of GnIH and its related peptides for the orexigenic effect. Anti-GnIH antiserum suppressed appetite induced by fasting, but did not modify feeding under ad libitum conditions. The present study suggests that GnIH and its related peptides act as endogenous orexigenic factors in the brain of chicks.

Original languageEnglish
Pages (from-to)94-100
Number of pages7
JournalBrain Research
Volume1050
Issue number1-2
DOIs
Publication statusPublished - 2005 Jul 19
Externally publishedYes

Fingerprint

Feeding Behavior
Gonadotropins
Hormones
Peptides
leucylproline
Pituitary Gonadotropins
Median Eminence
Paraventricular Hypothalamic Nucleus
Brain
Appetite
Invertebrates
Neuropeptides
Brain Stem
Vertebrates
Immune Sera
Chickens
Fasting
Eating

Keywords

  • Chick
  • Feeding
  • Gonadotropin-inhibiting hormone
  • Gonadotropin-releasing hormone
  • Intracerebroventricular injection
  • LPLRFamide

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Tachibana, T., Sato, M., Takahashi, H., Ukena, K., Tsutsui, K., & Furuse, M. (2005). Gonadotropin-inhibiting hormone stimulates feeding behavior in chicks. Brain Research, 1050(1-2), 94-100. https://doi.org/10.1016/j.brainres.2005.05.035

Gonadotropin-inhibiting hormone stimulates feeding behavior in chicks. / Tachibana, Tetsuya; Sato, Momoka; Takahashi, Hirokazu; Ukena, Kazuyoshi; Tsutsui, Kazuyoshi; Furuse, Mitsuhiro.

In: Brain Research, Vol. 1050, No. 1-2, 19.07.2005, p. 94-100.

Research output: Contribution to journalArticle

Tachibana, T, Sato, M, Takahashi, H, Ukena, K, Tsutsui, K & Furuse, M 2005, 'Gonadotropin-inhibiting hormone stimulates feeding behavior in chicks', Brain Research, vol. 1050, no. 1-2, pp. 94-100. https://doi.org/10.1016/j.brainres.2005.05.035
Tachibana, Tetsuya ; Sato, Momoka ; Takahashi, Hirokazu ; Ukena, Kazuyoshi ; Tsutsui, Kazuyoshi ; Furuse, Mitsuhiro. / Gonadotropin-inhibiting hormone stimulates feeding behavior in chicks. In: Brain Research. 2005 ; Vol. 1050, No. 1-2. pp. 94-100.
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