Gonadotropin-inhibitory hormone (GnIH): Discovery, progress and prospect

Kazuyoshi Tsutsui, Takayoshi Ubuka, George E. Bentley, Lance J. Kriegsfeld

    Research output: Contribution to journalArticle

    117 Citations (Scopus)

    Abstract

    A hypothalamic neuropeptide, gonadotropin-releasing hormone (GnRH), is the primary factor regulating gonadotropin secretion. An inhibitory hypothalamic neuropeptide for gonadotropin secretion was, until recently, unknown, although gonadal sex steroids and inhibin can modulate gonadotropin secretion. Findings from the last decade, however, indicate that GnRH is not the sole hypothalamic regulatory neuropeptide of vertebrate reproduction, with gonadotropin-inhibitory hormone (GnIH) playing a key role in the inhibition of reproduction. GnIH was originally identified in birds and subsequently in mammals and other vertebrates. GnIH acts on the pituitary and on GnRH neurons in the hypothalamus via a novel G protein-coupled receptor (GPR147). GnIH decreases gonadotropin synthesis and release, inhibiting gonadal development and maintenance. Such a down-regulation of the hypothalamo-pituitary-gonadal (HPG) axis may be conserved across vertebrates. Recent evidence further indicates that GnIH operates at the level of the gonads as an autocrine/paracrine regulator of steroidogenesis and gametogenesis. More recent evidence suggests that GnIH also acts both upstream of the GnRH system and at the level of the gonads to appropriately regulate reproductive activity across the seasons and during times of stress. The discovery of GnIH has fundamentally changed our understanding of hypothalamic control of reproduction. This review summarizes the discovery, progress and prospect of GnIH, a key regulator of vertebrate reproduction.

    Original languageEnglish
    Pages (from-to)305-314
    Number of pages10
    JournalGeneral and Comparative Endocrinology
    Volume177
    Issue number3
    DOIs
    Publication statusPublished - 2012 Jul 1

    Keywords

    • Gonadotropin-inhibitory hormone (GnIH)
    • Gonadotropin-releasing hormone (GnRH)
    • Gonadotropins
    • Hypothalamus
    • Melatonin
    • Pituitary
    • Reproduction
    • Reproductive behavior
    • Stress

    ASJC Scopus subject areas

    • Endocrinology

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