Gonadotropin-inhibitory hormone (GnIH) in the amphibian brain and its relationship with the gonadotropin releasing hormone (GnRH) system

An overview

Arun G. Jadhao, Claudia Pinelli, Biagio D'Aniello, Kazuyoshi Tsutsui

    Research output: Contribution to journalArticle

    7 Citations (Scopus)

    Abstract

    It is well known that the hypothalamic neuropeptide gonadotropin-releasing hormone (GnRH) plays an important role as a primary factor regulating gonadotropin secretion in reproductive processes in vertebrates. The discovery of the presence of a gonadotropin-inhibitory hormone (GnIH) in the brains of birds has further contributed to our understanding of the reproduction control by the brain. GnIH plays a key role in inhibition of reproduction and acts on the pituitary gland and GnRH neurons via a novel G protein-coupled receptor (GPR147). GnIH decreases gonadotropin synthesis and release, thus inhibiting gonadal development and maintenance. The GnRH and GnIH neuronal peptidergic systems are well reported in mammals and birds, but limited information is available regarding their presence and localization in the brains of other vertebrate species, such as reptiles, amphibians and fishes. The aim of this review is to compile and update information on the localization of GnRH and GnIH neuronal systems, with a particular focus on amphibians, summarizing the neuroanatomical distribution of GnIH and GnRH and emphasizing the discovery of GnIH based on RFamide peptides and GnIH orthologous peptides found in other vertebrates and their functional significance.

    Original languageEnglish
    Pages (from-to)69-76
    Number of pages8
    JournalGeneral and Comparative Endocrinology
    Volume240
    DOIs
    Publication statusPublished - 2017 Jan 1

    Fingerprint

    Amphibians
    gonadotropin-releasing hormone
    gonadotropins
    Gonadotropins
    Gonadotropin-Releasing Hormone
    amphibians
    hormones
    Hormones
    brain
    Brain
    Vertebrates
    vertebrates
    Birds
    Reproduction
    pituitary gonadotropins
    Pituitary Gonadotropins
    peptide hormones
    Reptiles
    Peptide Hormones
    pituitary gland

    Keywords

    • Gonadotropin-inhibitory hormone (GnIH)
    • Gonadotropin-releasing hormone (GnRH)
    • Neuropeptides
    • Pituitary
    • Reproduction
    • RFamide peptides

    ASJC Scopus subject areas

    • Endocrinology

    Cite this

    Gonadotropin-inhibitory hormone (GnIH) in the amphibian brain and its relationship with the gonadotropin releasing hormone (GnRH) system : An overview. / Jadhao, Arun G.; Pinelli, Claudia; D'Aniello, Biagio; Tsutsui, Kazuyoshi.

    In: General and Comparative Endocrinology, Vol. 240, 01.01.2017, p. 69-76.

    Research output: Contribution to journalArticle

    @article{8bbc0a9c966a4b8c806ee464e1235a2d,
    title = "Gonadotropin-inhibitory hormone (GnIH) in the amphibian brain and its relationship with the gonadotropin releasing hormone (GnRH) system: An overview",
    abstract = "It is well known that the hypothalamic neuropeptide gonadotropin-releasing hormone (GnRH) plays an important role as a primary factor regulating gonadotropin secretion in reproductive processes in vertebrates. The discovery of the presence of a gonadotropin-inhibitory hormone (GnIH) in the brains of birds has further contributed to our understanding of the reproduction control by the brain. GnIH plays a key role in inhibition of reproduction and acts on the pituitary gland and GnRH neurons via a novel G protein-coupled receptor (GPR147). GnIH decreases gonadotropin synthesis and release, thus inhibiting gonadal development and maintenance. The GnRH and GnIH neuronal peptidergic systems are well reported in mammals and birds, but limited information is available regarding their presence and localization in the brains of other vertebrate species, such as reptiles, amphibians and fishes. The aim of this review is to compile and update information on the localization of GnRH and GnIH neuronal systems, with a particular focus on amphibians, summarizing the neuroanatomical distribution of GnIH and GnRH and emphasizing the discovery of GnIH based on RFamide peptides and GnIH orthologous peptides found in other vertebrates and their functional significance.",
    keywords = "Gonadotropin-inhibitory hormone (GnIH), Gonadotropin-releasing hormone (GnRH), Neuropeptides, Pituitary, Reproduction, RFamide peptides",
    author = "Jadhao, {Arun G.} and Claudia Pinelli and Biagio D'Aniello and Kazuyoshi Tsutsui",
    year = "2017",
    month = "1",
    day = "1",
    doi = "10.1016/j.ygcen.2016.09.006",
    language = "English",
    volume = "240",
    pages = "69--76",
    journal = "General and Comparative Endocrinology",
    issn = "0016-6480",
    publisher = "Academic Press Inc.",

    }

    TY - JOUR

    T1 - Gonadotropin-inhibitory hormone (GnIH) in the amphibian brain and its relationship with the gonadotropin releasing hormone (GnRH) system

    T2 - An overview

    AU - Jadhao, Arun G.

    AU - Pinelli, Claudia

    AU - D'Aniello, Biagio

    AU - Tsutsui, Kazuyoshi

    PY - 2017/1/1

    Y1 - 2017/1/1

    N2 - It is well known that the hypothalamic neuropeptide gonadotropin-releasing hormone (GnRH) plays an important role as a primary factor regulating gonadotropin secretion in reproductive processes in vertebrates. The discovery of the presence of a gonadotropin-inhibitory hormone (GnIH) in the brains of birds has further contributed to our understanding of the reproduction control by the brain. GnIH plays a key role in inhibition of reproduction and acts on the pituitary gland and GnRH neurons via a novel G protein-coupled receptor (GPR147). GnIH decreases gonadotropin synthesis and release, thus inhibiting gonadal development and maintenance. The GnRH and GnIH neuronal peptidergic systems are well reported in mammals and birds, but limited information is available regarding their presence and localization in the brains of other vertebrate species, such as reptiles, amphibians and fishes. The aim of this review is to compile and update information on the localization of GnRH and GnIH neuronal systems, with a particular focus on amphibians, summarizing the neuroanatomical distribution of GnIH and GnRH and emphasizing the discovery of GnIH based on RFamide peptides and GnIH orthologous peptides found in other vertebrates and their functional significance.

    AB - It is well known that the hypothalamic neuropeptide gonadotropin-releasing hormone (GnRH) plays an important role as a primary factor regulating gonadotropin secretion in reproductive processes in vertebrates. The discovery of the presence of a gonadotropin-inhibitory hormone (GnIH) in the brains of birds has further contributed to our understanding of the reproduction control by the brain. GnIH plays a key role in inhibition of reproduction and acts on the pituitary gland and GnRH neurons via a novel G protein-coupled receptor (GPR147). GnIH decreases gonadotropin synthesis and release, thus inhibiting gonadal development and maintenance. The GnRH and GnIH neuronal peptidergic systems are well reported in mammals and birds, but limited information is available regarding their presence and localization in the brains of other vertebrate species, such as reptiles, amphibians and fishes. The aim of this review is to compile and update information on the localization of GnRH and GnIH neuronal systems, with a particular focus on amphibians, summarizing the neuroanatomical distribution of GnIH and GnRH and emphasizing the discovery of GnIH based on RFamide peptides and GnIH orthologous peptides found in other vertebrates and their functional significance.

    KW - Gonadotropin-inhibitory hormone (GnIH)

    KW - Gonadotropin-releasing hormone (GnRH)

    KW - Neuropeptides

    KW - Pituitary

    KW - Reproduction

    KW - RFamide peptides

    UR - http://www.scopus.com/inward/record.url?scp=84988950786&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84988950786&partnerID=8YFLogxK

    U2 - 10.1016/j.ygcen.2016.09.006

    DO - 10.1016/j.ygcen.2016.09.006

    M3 - Article

    VL - 240

    SP - 69

    EP - 76

    JO - General and Comparative Endocrinology

    JF - General and Comparative Endocrinology

    SN - 0016-6480

    ER -