Gonadotropin-inhibitory hormone mediates behavioral stress responses

Takayoshi Ubuka, Ishwar S. Parhar, Kazuyoshi Tsutsui

    Research output: Contribution to journalArticle

    3 Citations (Scopus)

    Abstract

    Gonadotropin-inhibitory hormone (GnIH) is an inhibitor of the hypothalamic-pituitary-gonadal (HPG) axis. GnIH is also called RFamide-related peptide (RFRP) as GnIH peptides have a characteristic C-terminal LPXRFiamide (X = L or Q) sequence. GnIH is thought to be the mediator of stress by negatively regulating the HPG axis as various stressors increase GnIH mRNA, GnIH peptide or GnIH neuronal activity. On the other hand, GnIH may also mediate behavioral stress responses as GnIH neuronal fibers and GnIH receptors are widely located in the limbic system of telencephalon, diencephalon and midbrain area. Previous studies have shown that intracerebroventricular (i.c.v.) administration of GnIH (RFRP) blocks morphine-induced analgesia in hot plate and formalin injection tests in rats suggesting that GnIH increases sensitivity to pain. GnIH (RFRP) also increases anxiety-like behavior in rats. RNA interference of GnIH gene (GnIH RNAi) increases locomotor activity of white-crowned sparrow and Japanese quail and i.c.v. administration of GnIH decreases GnIH RNAi induced locomotor activity. It was further shown that i.c.v. administration of GnIH (RFRP) decreases aggressive behavior in male quail and sexual behavior in male rats, female white-crowned sparrow and female hamsters. These results suggest that GnIH decreases threat to homeostasis of the organism by increasing pain sensitivity, anxiety and decreasing locomotor activity, aggressive behavior and sexual behavior. GnIH may also mediate the effect of stress on behavior.

    Original languageEnglish
    JournalGeneral and Comparative Endocrinology
    DOIs
    Publication statusAccepted/In press - 2018 Jan 1

    Fingerprint

    gonadotropins
    Gonadotropins
    stress response
    hormones
    Hormones
    Locomotion
    RNA Interference
    Sparrows
    peptides
    locomotion
    peptide hormones
    Peptide Hormones
    Passeriformes
    sexual behavior
    anxiety
    Sexual Behavior
    aggression
    pain
    rats
    Anxiety

    Keywords

    • Aggressive behavior
    • Anxiety
    • Homeostasis
    • Pain
    • Sexual behavior
    • Spontaneous activity

    ASJC Scopus subject areas

    • Animal Science and Zoology
    • Endocrinology

    Cite this

    Gonadotropin-inhibitory hormone mediates behavioral stress responses. / Ubuka, Takayoshi; Parhar, Ishwar S.; Tsutsui, Kazuyoshi.

    In: General and Comparative Endocrinology, 01.01.2018.

    Research output: Contribution to journalArticle

    @article{595f9ce025f3428e949867c854a106b5,
    title = "Gonadotropin-inhibitory hormone mediates behavioral stress responses",
    abstract = "Gonadotropin-inhibitory hormone (GnIH) is an inhibitor of the hypothalamic-pituitary-gonadal (HPG) axis. GnIH is also called RFamide-related peptide (RFRP) as GnIH peptides have a characteristic C-terminal LPXRFiamide (X = L or Q) sequence. GnIH is thought to be the mediator of stress by negatively regulating the HPG axis as various stressors increase GnIH mRNA, GnIH peptide or GnIH neuronal activity. On the other hand, GnIH may also mediate behavioral stress responses as GnIH neuronal fibers and GnIH receptors are widely located in the limbic system of telencephalon, diencephalon and midbrain area. Previous studies have shown that intracerebroventricular (i.c.v.) administration of GnIH (RFRP) blocks morphine-induced analgesia in hot plate and formalin injection tests in rats suggesting that GnIH increases sensitivity to pain. GnIH (RFRP) also increases anxiety-like behavior in rats. RNA interference of GnIH gene (GnIH RNAi) increases locomotor activity of white-crowned sparrow and Japanese quail and i.c.v. administration of GnIH decreases GnIH RNAi induced locomotor activity. It was further shown that i.c.v. administration of GnIH (RFRP) decreases aggressive behavior in male quail and sexual behavior in male rats, female white-crowned sparrow and female hamsters. These results suggest that GnIH decreases threat to homeostasis of the organism by increasing pain sensitivity, anxiety and decreasing locomotor activity, aggressive behavior and sexual behavior. GnIH may also mediate the effect of stress on behavior.",
    keywords = "Aggressive behavior, Anxiety, Homeostasis, Pain, Sexual behavior, Spontaneous activity",
    author = "Takayoshi Ubuka and Parhar, {Ishwar S.} and Kazuyoshi Tsutsui",
    year = "2018",
    month = "1",
    day = "1",
    doi = "10.1016/j.ygcen.2018.03.004",
    language = "English",
    journal = "General and Comparative Endocrinology",
    issn = "0016-6480",
    publisher = "Academic Press Inc.",

    }

    TY - JOUR

    T1 - Gonadotropin-inhibitory hormone mediates behavioral stress responses

    AU - Ubuka, Takayoshi

    AU - Parhar, Ishwar S.

    AU - Tsutsui, Kazuyoshi

    PY - 2018/1/1

    Y1 - 2018/1/1

    N2 - Gonadotropin-inhibitory hormone (GnIH) is an inhibitor of the hypothalamic-pituitary-gonadal (HPG) axis. GnIH is also called RFamide-related peptide (RFRP) as GnIH peptides have a characteristic C-terminal LPXRFiamide (X = L or Q) sequence. GnIH is thought to be the mediator of stress by negatively regulating the HPG axis as various stressors increase GnIH mRNA, GnIH peptide or GnIH neuronal activity. On the other hand, GnIH may also mediate behavioral stress responses as GnIH neuronal fibers and GnIH receptors are widely located in the limbic system of telencephalon, diencephalon and midbrain area. Previous studies have shown that intracerebroventricular (i.c.v.) administration of GnIH (RFRP) blocks morphine-induced analgesia in hot plate and formalin injection tests in rats suggesting that GnIH increases sensitivity to pain. GnIH (RFRP) also increases anxiety-like behavior in rats. RNA interference of GnIH gene (GnIH RNAi) increases locomotor activity of white-crowned sparrow and Japanese quail and i.c.v. administration of GnIH decreases GnIH RNAi induced locomotor activity. It was further shown that i.c.v. administration of GnIH (RFRP) decreases aggressive behavior in male quail and sexual behavior in male rats, female white-crowned sparrow and female hamsters. These results suggest that GnIH decreases threat to homeostasis of the organism by increasing pain sensitivity, anxiety and decreasing locomotor activity, aggressive behavior and sexual behavior. GnIH may also mediate the effect of stress on behavior.

    AB - Gonadotropin-inhibitory hormone (GnIH) is an inhibitor of the hypothalamic-pituitary-gonadal (HPG) axis. GnIH is also called RFamide-related peptide (RFRP) as GnIH peptides have a characteristic C-terminal LPXRFiamide (X = L or Q) sequence. GnIH is thought to be the mediator of stress by negatively regulating the HPG axis as various stressors increase GnIH mRNA, GnIH peptide or GnIH neuronal activity. On the other hand, GnIH may also mediate behavioral stress responses as GnIH neuronal fibers and GnIH receptors are widely located in the limbic system of telencephalon, diencephalon and midbrain area. Previous studies have shown that intracerebroventricular (i.c.v.) administration of GnIH (RFRP) blocks morphine-induced analgesia in hot plate and formalin injection tests in rats suggesting that GnIH increases sensitivity to pain. GnIH (RFRP) also increases anxiety-like behavior in rats. RNA interference of GnIH gene (GnIH RNAi) increases locomotor activity of white-crowned sparrow and Japanese quail and i.c.v. administration of GnIH decreases GnIH RNAi induced locomotor activity. It was further shown that i.c.v. administration of GnIH (RFRP) decreases aggressive behavior in male quail and sexual behavior in male rats, female white-crowned sparrow and female hamsters. These results suggest that GnIH decreases threat to homeostasis of the organism by increasing pain sensitivity, anxiety and decreasing locomotor activity, aggressive behavior and sexual behavior. GnIH may also mediate the effect of stress on behavior.

    KW - Aggressive behavior

    KW - Anxiety

    KW - Homeostasis

    KW - Pain

    KW - Sexual behavior

    KW - Spontaneous activity

    UR - http://www.scopus.com/inward/record.url?scp=85042930600&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=85042930600&partnerID=8YFLogxK

    U2 - 10.1016/j.ygcen.2018.03.004

    DO - 10.1016/j.ygcen.2018.03.004

    M3 - Article

    JO - General and Comparative Endocrinology

    JF - General and Comparative Endocrinology

    SN - 0016-6480

    ER -