Gonadotropin-inhibitory hormone reduces sexual motivation but not lordosis behavior in female Syrian hamsters (Mesocricetus auratus)

David J. Piekarski, Sheng Zhao, Kimberly J. Jennings, Takeshi Iwasa, Sandra J. Legan, Jens D. Mikkelsen, Kazuyoshi Tsutsui, Lance J. Kriegsfeld

    Research output: Contribution to journalArticle

    27 Citations (Scopus)

    Abstract

    Reproductive success is maximized when female sexual motivation and behavior coincide with the time of optimal fertility. Both processes depend upon coordinated hormonal events, beginning with signaling by the gonadotropin-releasing hormone (GnRH) neuronal system. Two neuropeptidergic systems that lie upstream of GnRH, gonadotropin-inhibitory hormone (GnIH; also known as RFamide related peptide-3) and kisspeptin, are potent inhibitory and excitatory modulators of GnRH, respectively, that participate in the timing of the preovulatory luteinizing hormone (LH) surge and ovulation. Whether these neuropeptides serve as neuromodulators to coordinate female sexual behavior with the limited window of fertility has not been thoroughly explored. In the present study, either intact or ovariectomized, hormone-treated female hamsters were implanted for fifteen days with chronic release osmotic pumps filled with GnIH or saline. The effect of GnIH on sexual motivation, vaginal scent marking, and lordosis was examined. Following mating, FOS activation was quantified in brain regions implicated in the regulation of female sexual behavior. Intracerebroventricular administration of GnIH reduced sexual motivation and vaginal scent marking, but not lordosis behavior. GnIH administration altered FOS expression in key neural loci implicated in female reproductive behavior, including the medial preoptic area, medial amygdala and bed nucleus of the stria terminalis, independent of changes in circulating gonadal steroids and kisspeptin cell activation. Together, these data point to GnIH as an important modulator of female proceptive sexual behavior and motivation, independent of downstream alterations in sex steroid production.

    Original languageEnglish
    Pages (from-to)501-510
    Number of pages10
    JournalHormones and Behavior
    Volume64
    Issue number3
    DOIs
    Publication statusPublished - 2013 Aug

    Fingerprint

    Lordosis
    Mesocricetus
    Gonadotropins
    Motivation
    Hormones
    Sexual Behavior
    Kisspeptins
    Gonadotropin-Releasing Hormone
    Fertility
    Steroids
    Reproductive Behavior
    Septal Nuclei
    Preoptic Area
    Luteinizing Hormone
    Ovulation
    Amygdala
    Neuropeptides
    Cricetinae
    Neurotransmitter Agents
    Brain

    Keywords

    • (RFRP)
    • Proceptivity
    • Receptivity
    • RFamide neuropeptides
    • RFamide related peptide

    ASJC Scopus subject areas

    • Endocrinology
    • Behavioral Neuroscience
    • Endocrine and Autonomic Systems

    Cite this

    Piekarski, D. J., Zhao, S., Jennings, K. J., Iwasa, T., Legan, S. J., Mikkelsen, J. D., ... Kriegsfeld, L. J. (2013). Gonadotropin-inhibitory hormone reduces sexual motivation but not lordosis behavior in female Syrian hamsters (Mesocricetus auratus). Hormones and Behavior, 64(3), 501-510. https://doi.org/10.1016/j.yhbeh.2013.06.006

    Gonadotropin-inhibitory hormone reduces sexual motivation but not lordosis behavior in female Syrian hamsters (Mesocricetus auratus). / Piekarski, David J.; Zhao, Sheng; Jennings, Kimberly J.; Iwasa, Takeshi; Legan, Sandra J.; Mikkelsen, Jens D.; Tsutsui, Kazuyoshi; Kriegsfeld, Lance J.

    In: Hormones and Behavior, Vol. 64, No. 3, 08.2013, p. 501-510.

    Research output: Contribution to journalArticle

    Piekarski, David J. ; Zhao, Sheng ; Jennings, Kimberly J. ; Iwasa, Takeshi ; Legan, Sandra J. ; Mikkelsen, Jens D. ; Tsutsui, Kazuyoshi ; Kriegsfeld, Lance J. / Gonadotropin-inhibitory hormone reduces sexual motivation but not lordosis behavior in female Syrian hamsters (Mesocricetus auratus). In: Hormones and Behavior. 2013 ; Vol. 64, No. 3. pp. 501-510.
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