Gracilioethers A-C, antimalarial metabolites from the marine sponge Agelas gracilis

Reiko Ueoka, Youichi Nakao, Shizuka Kawatsu, Junko Yaegashi, Yoshitsugu Matsumoto, Shigeki Matsunaga, Kazuo Furihata, Rob W M Van Soest, Nobuhiro Fusetani

    Research output: Contribution to journalArticle

    41 Citations (Scopus)

    Abstract

    (Chemical Equation Presented) Three new antiprotozoan compounds, gracilioethers A-C (1-3), have been isolated from the marine sponge Agelas gracilis. Their structures were elucidated on the basis of spectroscopic and chemical methods. Gracilioethers A-C showed antimalarial activity against Plasmodium falciparum with IC50 values of 0.5-10 μg/mL, whereas gracilioether B (2) also showed antileishmanial activity.

    Original languageEnglish
    Pages (from-to)4203-4207
    Number of pages5
    JournalJournal of Organic Chemistry
    Volume74
    Issue number11
    DOIs
    Publication statusPublished - 2009 Jun 5

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    Antimalarials
    Metabolites
    gracilioether A
    gracilioether B

    ASJC Scopus subject areas

    • Organic Chemistry

    Cite this

    Ueoka, R., Nakao, Y., Kawatsu, S., Yaegashi, J., Matsumoto, Y., Matsunaga, S., ... Fusetani, N. (2009). Gracilioethers A-C, antimalarial metabolites from the marine sponge Agelas gracilis. Journal of Organic Chemistry, 74(11), 4203-4207. https://doi.org/10.1021/jo900380f

    Gracilioethers A-C, antimalarial metabolites from the marine sponge Agelas gracilis. / Ueoka, Reiko; Nakao, Youichi; Kawatsu, Shizuka; Yaegashi, Junko; Matsumoto, Yoshitsugu; Matsunaga, Shigeki; Furihata, Kazuo; Van Soest, Rob W M; Fusetani, Nobuhiro.

    In: Journal of Organic Chemistry, Vol. 74, No. 11, 05.06.2009, p. 4203-4207.

    Research output: Contribution to journalArticle

    Ueoka, R, Nakao, Y, Kawatsu, S, Yaegashi, J, Matsumoto, Y, Matsunaga, S, Furihata, K, Van Soest, RWM & Fusetani, N 2009, 'Gracilioethers A-C, antimalarial metabolites from the marine sponge Agelas gracilis', Journal of Organic Chemistry, vol. 74, no. 11, pp. 4203-4207. https://doi.org/10.1021/jo900380f
    Ueoka, Reiko ; Nakao, Youichi ; Kawatsu, Shizuka ; Yaegashi, Junko ; Matsumoto, Yoshitsugu ; Matsunaga, Shigeki ; Furihata, Kazuo ; Van Soest, Rob W M ; Fusetani, Nobuhiro. / Gracilioethers A-C, antimalarial metabolites from the marine sponge Agelas gracilis. In: Journal of Organic Chemistry. 2009 ; Vol. 74, No. 11. pp. 4203-4207.
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    AU - Matsumoto, Yoshitsugu

    AU - Matsunaga, Shigeki

    AU - Furihata, Kazuo

    AU - Van Soest, Rob W M

    AU - Fusetani, Nobuhiro

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