Grafting poly(ethylene glycol) to a glass surface via a photocleavable linker for light-induced cell micropatterning and cell proliferation control

Yukiko Kikuchi, Jun Nakanishi, Hidekazu Nakayama, Takahiro Shimizu, Yutaro Yoshino, Kazuo Yamaguchi, Yasuhiko Yoshida, Yasuhiro Horiike

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Abstract

This paper describes a glass substrate having a photocleavable poly(ethylene glycol) (PEG) designed for light-induced cell micropatterning. The substrate changed from non-cell-adhesive to cell-adhesive by the photocleavage of PEG. Cellular patterns maintained for more than 17 days, and they were able to be changed to control cell migration and proliferation at multi- and single-cell levels by irradiating their adjacent regions during cell cultivation.

Original languageEnglish
Pages (from-to)1062-1063
Number of pages2
JournalChemistry Letters
Volume37
Issue number10
DOIs
Publication statusPublished - 2008 Dec 1

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ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Kikuchi, Y., Nakanishi, J., Nakayama, H., Shimizu, T., Yoshino, Y., Yamaguchi, K., Yoshida, Y., & Horiike, Y. (2008). Grafting poly(ethylene glycol) to a glass surface via a photocleavable linker for light-induced cell micropatterning and cell proliferation control. Chemistry Letters, 37(10), 1062-1063. https://doi.org/10.1246/cl.2008.1062