Greater adenosine A2A receptor densities in cardiac and skeletal muscle in endurance-trained men: A [11C]TMSX PET study

Masaki Mizuno, Yuichi Kimura, Ken Tokizawa, Kenji Ishii, Keiichi Oda, Toru Sasaki, Yoshio Nakamura, Isao Muraoka, Kiichi Ishiwata

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

We examined the densities of adenosine A2A receptors in cardiac and skeletal muscles between untrained and endurance-trained subjects using positron emission tomography (PET) and [7-methyl-11C]-(E)-8-(3,4,5- trimethoxystyryl)-1,3,7-trimethylxanthine ([11C]TMSX), a newly developed radioligand for mapping adenosine A2A receptors. Five untrained and five endurance-trained subjects participated in this study. The density of adenosine A2A receptors was evaluated as the distribution volume of [11C]TMSX in cardiac and triceps brachii muscles in the resting state using PET. The distribution volume of [11C]TMSX in the myocardium was significantly greater than in the triceps brachii muscle in both groups. Further, distribution volumes [11C]TMSX in the trained subjects were significantly grater than those in untrained subjects (myocardium, 3.6±0.3 vs. 3.1±0.4 ml g-1; triceps brachii muscle, 1.7±0.3 vs. 1.2±0.2 ml g-1, respectively). These results indicate that the densities of adenosine A2A receptors in the cardiac and skeletal muscles are greater in the endurance-trained men than in the untrained men.

Original languageEnglish
Pages (from-to)831-836
Number of pages6
JournalNuclear Medicine and Biology
Volume32
Issue number8
DOIs
Publication statusPublished - 2005 Nov 1

Keywords

  • Adenosine A receptor
  • Heart
  • Human
  • Positron emission tomography
  • Skeletal muscle
  • Training

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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