TY - JOUR
T1 - Greater adenosine A2A receptor densities in cardiac and skeletal muscle in endurance-trained men
T2 - A [11C]TMSX PET study
AU - Mizuno, Masaki
AU - Kimura, Yuichi
AU - Tokizawa, Ken
AU - Ishii, Kenji
AU - Oda, Keiichi
AU - Sasaki, Toru
AU - Nakamura, Yoshio
AU - Muraoka, Isao
AU - Ishiwata, Kiichi
N1 - Funding Information:
This work was supported by grant-in-aid for scientific research (B) no. 16390348 from the Japan Society for the promotion of Science. We thank Dr. Kazunori Kawamura for manufacture of the radiopharmaceuticals and Ms. Miyoko Ando for care of the subjects during the PET measurements.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2005/11
Y1 - 2005/11
N2 - We examined the densities of adenosine A2A receptors in cardiac and skeletal muscles between untrained and endurance-trained subjects using positron emission tomography (PET) and [7-methyl-11C]-(E)-8-(3,4,5- trimethoxystyryl)-1,3,7-trimethylxanthine ([11C]TMSX), a newly developed radioligand for mapping adenosine A2A receptors. Five untrained and five endurance-trained subjects participated in this study. The density of adenosine A2A receptors was evaluated as the distribution volume of [11C]TMSX in cardiac and triceps brachii muscles in the resting state using PET. The distribution volume of [11C]TMSX in the myocardium was significantly greater than in the triceps brachii muscle in both groups. Further, distribution volumes [11C]TMSX in the trained subjects were significantly grater than those in untrained subjects (myocardium, 3.6±0.3 vs. 3.1±0.4 ml g-1; triceps brachii muscle, 1.7±0.3 vs. 1.2±0.2 ml g-1, respectively). These results indicate that the densities of adenosine A2A receptors in the cardiac and skeletal muscles are greater in the endurance-trained men than in the untrained men.
AB - We examined the densities of adenosine A2A receptors in cardiac and skeletal muscles between untrained and endurance-trained subjects using positron emission tomography (PET) and [7-methyl-11C]-(E)-8-(3,4,5- trimethoxystyryl)-1,3,7-trimethylxanthine ([11C]TMSX), a newly developed radioligand for mapping adenosine A2A receptors. Five untrained and five endurance-trained subjects participated in this study. The density of adenosine A2A receptors was evaluated as the distribution volume of [11C]TMSX in cardiac and triceps brachii muscles in the resting state using PET. The distribution volume of [11C]TMSX in the myocardium was significantly greater than in the triceps brachii muscle in both groups. Further, distribution volumes [11C]TMSX in the trained subjects were significantly grater than those in untrained subjects (myocardium, 3.6±0.3 vs. 3.1±0.4 ml g-1; triceps brachii muscle, 1.7±0.3 vs. 1.2±0.2 ml g-1, respectively). These results indicate that the densities of adenosine A2A receptors in the cardiac and skeletal muscles are greater in the endurance-trained men than in the untrained men.
KW - Adenosine A receptor
KW - Heart
KW - Human
KW - Positron emission tomography
KW - Skeletal muscle
KW - Training
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U2 - 10.1016/j.nucmedbio.2005.07.003
DO - 10.1016/j.nucmedbio.2005.07.003
M3 - Article
C2 - 16253807
AN - SCOPUS:27144538224
SN - 0969-8051
VL - 32
SP - 831
EP - 836
JO - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
JF - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
IS - 8
ER -
