Greater progression of age-related aortic stiffening in adults with poor trunk flexibility: A 5-year longitudinal study

Yuko Gando, Haruka Murakami, Kenta Yamamoto, Ryoko Kawakami, Harumi Ohno, Susumu Sawada, Nobuyuki Miyatake, Motohiko Miyachi

Research output: Contribution to journalArticle

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Abstract

Purpose: Having a low level of physical fitness, especially cardiorespiratory fitness, appears to accelerate age-related aortic stiffening. Whereas, some studies have reported that trunk flexibility is a component of physical fitness, it is also negatively associated with arterial stiffening independent of cardiorespiratory fitness in cross-sectional studies. However, no long-term longitudinal study has determined whether poor trunk flexibility accelerates the progression of age-related aortic stiffening. We examined trunk flexibility and aortic stiffness progression in a 5-year longitudinal study. Methods and Results: A total of 305 apparently healthy men and women participated in this study (49.6 ± 9.5 years of age). Trunk flexibility was measured using a sit-and-reach test. Aortic stiffness was assessed using carotid-femoral pulse wave velocity (cfPWV) at baseline and after 5 years. Analysis of covariance (ANCOVA) was used to assess the association of the annual rate of cfPWV across flexibility levels (low, middle, high). There were no significant differences in baseline cfPWV among the three groups (835 ± 164, 853 ± 140, 855 ± 2.68 cm/s; P = 0.577). Annual ?cfPWV was significantly higher in the low-flexibility group than in the high-flexibility group (P = 0.009). ANCOVA revealed an inverse relationship between flexibility level and annual ΔcfPWV (14.41 ± 2.73, 9.79 ± 2.59, 2.62 ± 2.68 cm/s/year; P for trend = 0.011). Multiple regression analysis revealed that baseline sit and reach (β = -0.12, -0.70 to -0.01) was independently correlated with ?cfPWV following adjustment for baseline peak oxygen uptake, age, sex, body fat, heart rate, and cfPWV. The 5-year change in cfPWV was not significantly correlated with 5-year change in sit-and-reach performance (P = 0.859). Conclusion: Poor trunk flexibility is associated with greater progression of age-related aortic stiffening in healthy adults. However, we failed to confirm a significant association between 5-year change in aortic stiffness and 5-year change in trunk flexibility. The association between increased age-related increase in aortic stiffness and deterioration in flexibility due to age may require observation for more than 5 years.

Original languageEnglish
Article number454
JournalFrontiers in Physiology
Volume8
Issue numberJUN
DOIs
Publication statusPublished - 2017 Jun 30

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Pulse Wave Analysis
Thigh
Longitudinal Studies
Vascular Stiffness
Physical Fitness
Adipose Tissue
Cross-Sectional Studies
Heart Rate
Regression Analysis
Observation
Oxygen

Keywords

  • Aging
  • Arteriosclerosis
  • Fitness
  • Primary prevention
  • Trunk flexibility

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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Greater progression of age-related aortic stiffening in adults with poor trunk flexibility : A 5-year longitudinal study. / Gando, Yuko; Murakami, Haruka; Yamamoto, Kenta; Kawakami, Ryoko; Ohno, Harumi; Sawada, Susumu; Miyatake, Nobuyuki; Miyachi, Motohiko.

In: Frontiers in Physiology, Vol. 8, No. JUN, 454, 30.06.2017.

Research output: Contribution to journalArticle

Gando, Yuko ; Murakami, Haruka ; Yamamoto, Kenta ; Kawakami, Ryoko ; Ohno, Harumi ; Sawada, Susumu ; Miyatake, Nobuyuki ; Miyachi, Motohiko. / Greater progression of age-related aortic stiffening in adults with poor trunk flexibility : A 5-year longitudinal study. In: Frontiers in Physiology. 2017 ; Vol. 8, No. JUN.
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AU - Gando, Yuko

AU - Murakami, Haruka

AU - Yamamoto, Kenta

AU - Kawakami, Ryoko

AU - Ohno, Harumi

AU - Sawada, Susumu

AU - Miyatake, Nobuyuki

AU - Miyachi, Motohiko

PY - 2017/6/30

Y1 - 2017/6/30

N2 - Purpose: Having a low level of physical fitness, especially cardiorespiratory fitness, appears to accelerate age-related aortic stiffening. Whereas, some studies have reported that trunk flexibility is a component of physical fitness, it is also negatively associated with arterial stiffening independent of cardiorespiratory fitness in cross-sectional studies. However, no long-term longitudinal study has determined whether poor trunk flexibility accelerates the progression of age-related aortic stiffening. We examined trunk flexibility and aortic stiffness progression in a 5-year longitudinal study. Methods and Results: A total of 305 apparently healthy men and women participated in this study (49.6 ± 9.5 years of age). Trunk flexibility was measured using a sit-and-reach test. Aortic stiffness was assessed using carotid-femoral pulse wave velocity (cfPWV) at baseline and after 5 years. Analysis of covariance (ANCOVA) was used to assess the association of the annual rate of cfPWV across flexibility levels (low, middle, high). There were no significant differences in baseline cfPWV among the three groups (835 ± 164, 853 ± 140, 855 ± 2.68 cm/s; P = 0.577). Annual ?cfPWV was significantly higher in the low-flexibility group than in the high-flexibility group (P = 0.009). ANCOVA revealed an inverse relationship between flexibility level and annual ΔcfPWV (14.41 ± 2.73, 9.79 ± 2.59, 2.62 ± 2.68 cm/s/year; P for trend = 0.011). Multiple regression analysis revealed that baseline sit and reach (β = -0.12, -0.70 to -0.01) was independently correlated with ?cfPWV following adjustment for baseline peak oxygen uptake, age, sex, body fat, heart rate, and cfPWV. The 5-year change in cfPWV was not significantly correlated with 5-year change in sit-and-reach performance (P = 0.859). Conclusion: Poor trunk flexibility is associated with greater progression of age-related aortic stiffening in healthy adults. However, we failed to confirm a significant association between 5-year change in aortic stiffness and 5-year change in trunk flexibility. The association between increased age-related increase in aortic stiffness and deterioration in flexibility due to age may require observation for more than 5 years.

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KW - Arteriosclerosis

KW - Fitness

KW - Primary prevention

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