Growth-promoting and antimetamorphic hormone in pituitary glands of bullfrogs

Sakaé Kikuyama*, Kazutoshi Yamamoto, Masako Mayumi

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    21 Citations (Scopus)


    Among the fractions separated from pituitary glands of both larval and adult Rana catesbeiana by disc gel electrophoresis, only a fast moving protein fraction had both a pronounced stimulating effect on the collagen synthesis in the tail fin of bullfrog tadpoles and a suppressive effect on T4-induced resorption of Bufo bufo japonicus tadpole tails in vitro. Pigeon crop-sac test revealed that the fraction had a pronounced prolactin activity. It was demonstrated that this fraction was about four times as potent as bovine prolactin in promoting collagen synthesis in the tadpole tail fin.

    Original languageEnglish
    Pages (from-to)212-216
    Number of pages5
    JournalGeneral and Comparative Endocrinology
    Issue number2
    Publication statusPublished - 1980

    ASJC Scopus subject areas

    • Endocrinology


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