Habitual exercise decreases plasma xanthine oxidoreductase activity in middle-Aged and older women

Keisei Kosaki, Atsuko Kamijo-Ikemori, Takeshi Sugaya, Koichiro Tanahashi, Nobuhiko Akazawa, Chihiro Hibi, Takashi Nakamura, Takayo Murase, Kenjiro Kimura, Yugo Shibagaki, Seiji Maeda*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The aim of present study was to investigate the association plasma xanthine oxidoreductase activity, which has gained attention as a novel preventive target of cardiovascular disease, and various physiological parameters and was to determine the effects of habitual exercise on plasma xanthine oxidoreductase activity in middle-Aged and older women. In the cross-sectional study, we investigated the association between plasma xanthine oxidoreductase activity and various physiological parameters in 94 middle-Aged and older women. In the interventional study, subjects (n = 22) were divided into two groups: exercise (n = 12) or the control group (n = 10), whereby we examined the effect of 12-week aerobic exercise training on plasma xanthine oxidoreduc- tase activity in middle-Aged and older women. The cross-sectional study demonstrated that plasma xanthine oxidoreductase activity was significantly associated with various physiological parameters, including visceral fat and daily step counts. In the interventional study, the plasma xanthine oxidoreductase activity significantly decreased after the 12-week aerobic exercise training, its changes were inversely associated with the changes in daily step counts. Our results revealed that the plasma xanthine oxidoreductase activity was associated with visceral fat accumulation and lack of exercise, and it was decreased by the aerobic exercise training.

Original languageEnglish
Pages (from-to)247-253
Number of pages7
JournalJournal of Clinical Biochemistry and Nutrition
Volume62
Issue number3
DOIs
Publication statusPublished - 2018
Externally publishedYes

Keywords

  • Aerobic exercise training
  • Cardiovascular disease risks
  • Daily step counts
  • Visceral fat

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Clinical Biochemistry

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