Abstract
The purpose of this study was to test the hypothesis that regular exercise training in elderly people affects the type 1/type 2 balance. Nine elderly women who train by walking (mean±S.E.M., age 63±1 years, VO 2 peak 32.2±1.0 ml kg-1 min-1), 12 age-matched untrained women (63±1 years, 27.8±0.9 ml kg -1 min-1), and nine young untrained women (26±1 years, 37.8±1.3 ml kg-1 min-1) participated in the study. We measured interferon γ (IFN-γ), IL-2, and IL-4 in CD4+ and CD8+ T cells, to compare type 1 and type 2 T cells. The number of CD4+ cells expressing intracellular IFN-γ (CD4+/IFN-γ cell) significantly higher in the elderly trained than in the young (P<0.01). The number of CD8+/IL-2 cells was significantly higher in the elderly trained than in the elderly untrained (P<0.05). The number of CD8+/IL-4 cells was significantly higher in the young than in the elderly untrained (P<0.01). No significant differences were apparent in the IFN-γ/IL-4 ratio within CD4+ and CD8+ cells from the three groups. These results might indicate that the effect of age on the balance of type 1/type 2 T cells was stronger than the effect of physical training.
| Original language | English |
|---|---|
| Pages (from-to) | 951-956 |
| Number of pages | 6 |
| Journal | Mechanisms of Ageing and Development |
| Volume | 124 |
| Issue number | 8-9 |
| DOIs | |
| Publication status | Published - 2003 Aug |
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Keywords
- Aging
- Exercise
- Immunity
- Interferon-gamma
- Interleukin-4
- T-lymphocytes
ASJC Scopus subject areas
- Ageing
- Biochemistry
- Developmental Biology
- Developmental Neuroscience
Cite this
Habitual exercise did not affect the balance of type 1 and type 2 cytokines in elderly people. / Ogawa, Kishiko; Oka, Jun; Yamakawa, Jun; Higuchi, Mitsuru.
In: Mechanisms of Ageing and Development, Vol. 124, No. 8-9, 08.2003, p. 951-956.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Habitual exercise did not affect the balance of type 1 and type 2 cytokines in elderly people
AU - Ogawa, Kishiko
AU - Oka, Jun
AU - Yamakawa, Jun
AU - Higuchi, Mitsuru
PY - 2003/8
Y1 - 2003/8
N2 - The purpose of this study was to test the hypothesis that regular exercise training in elderly people affects the type 1/type 2 balance. Nine elderly women who train by walking (mean±S.E.M., age 63±1 years, VO 2 peak 32.2±1.0 ml kg-1 min-1), 12 age-matched untrained women (63±1 years, 27.8±0.9 ml kg -1 min-1), and nine young untrained women (26±1 years, 37.8±1.3 ml kg-1 min-1) participated in the study. We measured interferon γ (IFN-γ), IL-2, and IL-4 in CD4+ and CD8+ T cells, to compare type 1 and type 2 T cells. The number of CD4+ cells expressing intracellular IFN-γ (CD4+/IFN-γ cell) significantly higher in the elderly trained than in the young (P<0.01). The number of CD8+/IL-2 cells was significantly higher in the elderly trained than in the elderly untrained (P<0.05). The number of CD8+/IL-4 cells was significantly higher in the young than in the elderly untrained (P<0.01). No significant differences were apparent in the IFN-γ/IL-4 ratio within CD4+ and CD8+ cells from the three groups. These results might indicate that the effect of age on the balance of type 1/type 2 T cells was stronger than the effect of physical training.
AB - The purpose of this study was to test the hypothesis that regular exercise training in elderly people affects the type 1/type 2 balance. Nine elderly women who train by walking (mean±S.E.M., age 63±1 years, VO 2 peak 32.2±1.0 ml kg-1 min-1), 12 age-matched untrained women (63±1 years, 27.8±0.9 ml kg -1 min-1), and nine young untrained women (26±1 years, 37.8±1.3 ml kg-1 min-1) participated in the study. We measured interferon γ (IFN-γ), IL-2, and IL-4 in CD4+ and CD8+ T cells, to compare type 1 and type 2 T cells. The number of CD4+ cells expressing intracellular IFN-γ (CD4+/IFN-γ cell) significantly higher in the elderly trained than in the young (P<0.01). The number of CD8+/IL-2 cells was significantly higher in the elderly trained than in the elderly untrained (P<0.05). The number of CD8+/IL-4 cells was significantly higher in the young than in the elderly untrained (P<0.01). No significant differences were apparent in the IFN-γ/IL-4 ratio within CD4+ and CD8+ cells from the three groups. These results might indicate that the effect of age on the balance of type 1/type 2 T cells was stronger than the effect of physical training.
KW - Aging
KW - Exercise
KW - Immunity
KW - Interferon-gamma
KW - Interleukin-4
KW - T-lymphocytes
UR - http://www.scopus.com/inward/record.url?scp=0141429183&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0141429183&partnerID=8YFLogxK
U2 - 10.1016/S0047-6374(03)00167-2
DO - 10.1016/S0047-6374(03)00167-2
M3 - Article
C2 - 14499500
AN - SCOPUS:0141429183
VL - 124
SP - 951
EP - 956
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
SN - 0047-6374
IS - 8-9
ER -