Haemoglobin-vesicles as artificial oxygen carriers: Present situation and future visions

H. Sakai, K. Sou, H. Horinouchi, K. Kobayashi, E. Tsuchida

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

During the long history of development of haemoglobin (Hb)-based O 2 carriers (HBOCs), many side effects of Hb molecules have become apparent. They imply the physiological importance of the cellular structure of red blood cells. Hb-vesicles (HbV) are artificial O2 carriers that encapsulate concentrated Hb solution with a thin lipid membrane. We have overcome the intrinsic issues of the suspension of HbV as a molecular assembly, such as stability for storage and in blood circulation, blood compatibility and prompt degradation in the reticuloendothelial system. Animal tests clarified the efficacy of HbV as a transfusion alternative and the possibility for other clinical applications. The results of ongoing HbV research make us confident in advancing further development of HbV, with the expectation of its eventual realization.

Original languageEnglish
Pages (from-to)4-15
Number of pages12
JournalJournal of Internal Medicine
Volume263
Issue number1
DOIs
Publication statusPublished - 2008 Jan

Keywords

  • Artificial oxygen carrier
  • Biocompatibility
  • Liposome
  • Nanotechnology
  • Polyethylene glycol

ASJC Scopus subject areas

  • Internal Medicine

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