Haemostatic effects of fibrinogen y chain dodecapeptide-conjugates as platelet substitutes

Yosuke Okamura, Ippei Maekawa, Toshinori Fujie, Shinji Takeoka, Makoto Handa, Yasuo Ikeda

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have studied prototypes of platelet substitutes by conjugating the dodecapeptide (H12); a part of the amino acid sequence of fibrinogen, to the surface of polymerized albumin particles (polyAlb) or phospholipid vesicles (vesicle). Both H12-polyAlb and H12-vesicle showed a hemostatic effect, based on the analysis of the tail bleeding time of thrombocytopenic rats. The H12-polyAlb was more effective than the H12-vesicle.

Original languageEnglish
Title of host publicationPolymer Preprints, Japan
Pages2267
Number of pages1
Volume54
Edition1
Publication statusPublished - 2005
Event54th SPSJ Annual Meeting 2005 - Yokohama
Duration: 2005 May 252005 May 27

Other

Other54th SPSJ Annual Meeting 2005
CityYokohama
Period05/5/2505/5/27

Fingerprint

Phospholipids
Platelets
Amino acids
Rats

Keywords

  • Albumin
  • Fibrinogen γ chain dodecapeptide (H12)
  • Haemostatic effect
  • Platelet substitutes
  • Thrombocytopenic rats
  • Vesicles

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Okamura, Y., Maekawa, I., Fujie, T., Takeoka, S., Handa, M., & Ikeda, Y. (2005). Haemostatic effects of fibrinogen y chain dodecapeptide-conjugates as platelet substitutes. In Polymer Preprints, Japan (1 ed., Vol. 54, pp. 2267)

Haemostatic effects of fibrinogen y chain dodecapeptide-conjugates as platelet substitutes. / Okamura, Yosuke; Maekawa, Ippei; Fujie, Toshinori; Takeoka, Shinji; Handa, Makoto; Ikeda, Yasuo.

Polymer Preprints, Japan. Vol. 54 1. ed. 2005. p. 2267.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Okamura, Y, Maekawa, I, Fujie, T, Takeoka, S, Handa, M & Ikeda, Y 2005, Haemostatic effects of fibrinogen y chain dodecapeptide-conjugates as platelet substitutes. in Polymer Preprints, Japan. 1 edn, vol. 54, pp. 2267, 54th SPSJ Annual Meeting 2005, Yokohama, 05/5/25.
Okamura Y, Maekawa I, Fujie T, Takeoka S, Handa M, Ikeda Y. Haemostatic effects of fibrinogen y chain dodecapeptide-conjugates as platelet substitutes. In Polymer Preprints, Japan. 1 ed. Vol. 54. 2005. p. 2267
Okamura, Yosuke ; Maekawa, Ippei ; Fujie, Toshinori ; Takeoka, Shinji ; Handa, Makoto ; Ikeda, Yasuo. / Haemostatic effects of fibrinogen y chain dodecapeptide-conjugates as platelet substitutes. Polymer Preprints, Japan. Vol. 54 1. ed. 2005. pp. 2267
@inproceedings{fb7f3c039fb44711bd10b6504f0321da,
title = "Haemostatic effects of fibrinogen y chain dodecapeptide-conjugates as platelet substitutes",
abstract = "We have studied prototypes of platelet substitutes by conjugating the dodecapeptide (H12); a part of the amino acid sequence of fibrinogen, to the surface of polymerized albumin particles (polyAlb) or phospholipid vesicles (vesicle). Both H12-polyAlb and H12-vesicle showed a hemostatic effect, based on the analysis of the tail bleeding time of thrombocytopenic rats. The H12-polyAlb was more effective than the H12-vesicle.",
keywords = "Albumin, Fibrinogen γ chain dodecapeptide (H12), Haemostatic effect, Platelet substitutes, Thrombocytopenic rats, Vesicles",
author = "Yosuke Okamura and Ippei Maekawa and Toshinori Fujie and Shinji Takeoka and Makoto Handa and Yasuo Ikeda",
year = "2005",
language = "English",
volume = "54",
pages = "2267",
booktitle = "Polymer Preprints, Japan",
edition = "1",

}

TY - GEN

T1 - Haemostatic effects of fibrinogen y chain dodecapeptide-conjugates as platelet substitutes

AU - Okamura, Yosuke

AU - Maekawa, Ippei

AU - Fujie, Toshinori

AU - Takeoka, Shinji

AU - Handa, Makoto

AU - Ikeda, Yasuo

PY - 2005

Y1 - 2005

N2 - We have studied prototypes of platelet substitutes by conjugating the dodecapeptide (H12); a part of the amino acid sequence of fibrinogen, to the surface of polymerized albumin particles (polyAlb) or phospholipid vesicles (vesicle). Both H12-polyAlb and H12-vesicle showed a hemostatic effect, based on the analysis of the tail bleeding time of thrombocytopenic rats. The H12-polyAlb was more effective than the H12-vesicle.

AB - We have studied prototypes of platelet substitutes by conjugating the dodecapeptide (H12); a part of the amino acid sequence of fibrinogen, to the surface of polymerized albumin particles (polyAlb) or phospholipid vesicles (vesicle). Both H12-polyAlb and H12-vesicle showed a hemostatic effect, based on the analysis of the tail bleeding time of thrombocytopenic rats. The H12-polyAlb was more effective than the H12-vesicle.

KW - Albumin

KW - Fibrinogen γ chain dodecapeptide (H12)

KW - Haemostatic effect

KW - Platelet substitutes

KW - Thrombocytopenic rats

KW - Vesicles

UR - http://www.scopus.com/inward/record.url?scp=33645642239&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645642239&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:33645642239

VL - 54

SP - 2267

BT - Polymer Preprints, Japan

ER -