Haemostatic effects of polymerized albumin particles carrying fibrinogen-γ chain dodecapeptide as platelet substitutes in vitro and in vivo

Yosuke Okamura, Toshinori Fujie, Makoto Handa, Yasuo Ikeda, Shinji Takeoka

Research output: Contribution to conferencePaperpeer-review

Abstract

We have studied prototypes of platelet substitutes and focused on the dodecapeptide (H12); a part of the amino acid sequence of fibrinogen as activated platelets, and conjugated H12 to the surface of polymerized albumin particles (polyAlb) as biocompatible and biodegradable particles. The H12-conjugated polyAlb (H12-polyAlb) adding to the thrombocytopenic-imitation blood enhanced the platelet thrombus formation on a collagen-plate in vitro. We confirmed that H12-polyAlb had a hemostatic effect, based on the analysis of the tail bleeding time of thrombocytopenic rats. H12-polyAlb is a suitable candidate for an alternative to human platelet concentrates infused into thrombocytopenic patients.

Original languageEnglish
Pages4933-4934
Number of pages2
Publication statusPublished - 2005 Dec 1
Event54th SPSJ Symposium on Macromolecules - Yamagata, Japan
Duration: 2005 Sep 202005 Sep 22

Other

Other54th SPSJ Symposium on Macromolecules
CountryJapan
CityYamagata
Period05/9/2005/9/22

Keywords

  • Fibrinogen γ chain dodecapeptide (H12)
  • Flow conditions
  • Haemostatic effects
  • Platelet substitutes
  • Polymerized albumin particles (polyAlb)
  • Thrombocytopenic rats

ASJC Scopus subject areas

  • Engineering(all)

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