Halistanol sulfates i and J, new SIRT1-3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria

Fumiaki Nakamura; Norio Kudo; Yuki Tomachi; Akiko Nakata; Misao Takemoto; Akihiro Ito; Hodaka Tabei; Daisuke Arai; Nicole De Voogd; Minoru Yoshida; Yoichi Nakao; Nobuhiro Fusetani

doi:10.1038/ja.2017.145

Halistanol sulfates i and J, new SIRT1-3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria

Fumiaki Nakamura, Norio Kudo, Yuki Tomachi, Akiko Nakata, Misao Takemoto, Akihiro Ito, Hodaka Tabei, Daisuke Arai, Nicole De Voogd, Minoru Yoshida, Yoichi Nakao, Nobuhiro Fusetani

School of Advanced Science and Engineering

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Two new analogs of halistanol sulfate (1) were isolated from a marine sponge Halichondria sp. collected at Hachijo-jima Island. Structures of these new halistanol sulfates I (2) and J (3) were elucidated by spectral analyses. Compounds 1-3 showed inhibitory activity against SIRT 1-3 with IC 50 ranges of 45.9-67.9, 18.9-21.1 and 21.8-37.5 μM, respectively. X-ray crystallography of the halistanol sulfate (1) and SIRT3 complex clearly indicates that 1 binds to the exosite of SIRT3 that we have discovered in this study.

Original language	English
Pages (from-to)	273-278
Number of pages	6
Journal	Journal of Antibiotics
Volume	71
Issue number	2
DOIs	https://doi.org/10.1038/ja.2017.145
Publication status	Published - 2018 Feb 1

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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Halistanol sulfates i and J, new SIRT1-3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria. / Nakamura, Fumiaki; Kudo, Norio; Tomachi, Yuki; Nakata, Akiko; Takemoto, Misao; Ito, Akihiro; Tabei, Hodaka; Arai, Daisuke; De Voogd, Nicole; Yoshida, Minoru; Nakao, Yoichi; Fusetani, Nobuhiro.

In: Journal of Antibiotics, Vol. 71, No. 2, 01.02.2018, p. 273-278.

Research output: Contribution to journal › Article › peer-review

Nakamura, Fumiaki ; Kudo, Norio ; Tomachi, Yuki ; Nakata, Akiko ; Takemoto, Misao ; Ito, Akihiro ; Tabei, Hodaka ; Arai, Daisuke ; De Voogd, Nicole ; Yoshida, Minoru ; Nakao, Yoichi ; Fusetani, Nobuhiro. / Halistanol sulfates i and J, new SIRT1-3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria. In: Journal of Antibiotics. 2018 ; Vol. 71, No. 2. pp. 273-278.

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abstract = "Two new analogs of halistanol sulfate (1) were isolated from a marine sponge Halichondria sp. collected at Hachijo-jima Island. Structures of these new halistanol sulfates I (2) and J (3) were elucidated by spectral analyses. Compounds 1-3 showed inhibitory activity against SIRT 1-3 with IC 50 ranges of 45.9-67.9, 18.9-21.1 and 21.8-37.5 μM, respectively. X-ray crystallography of the halistanol sulfate (1) and SIRT3 complex clearly indicates that 1 binds to the exosite of SIRT3 that we have discovered in this study.",

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AU - Kudo, Norio

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AU - Nakata, Akiko

AU - Takemoto, Misao

AU - Ito, Akihiro

AU - Tabei, Hodaka

AU - Arai, Daisuke

AU - De Voogd, Nicole

AU - Yoshida, Minoru

AU - Nakao, Yoichi

AU - Fusetani, Nobuhiro

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