Abstract
Two new analogs of halistanol sulfate (1) were isolated from a marine sponge Halichondria sp. collected at Hachijo-jima Island. Structures of these new halistanol sulfates I (2) and J (3) were elucidated by spectral analyses. Compounds 1-3 showed inhibitory activity against SIRT 1-3 with IC 50 ranges of 45.9-67.9, 18.9-21.1 and 21.8-37.5 μM, respectively. X-ray crystallography of the halistanol sulfate (1) and SIRT3 complex clearly indicates that 1 binds to the exosite of SIRT3 that we have discovered in this study.
Original language | English |
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Pages (from-to) | 273-278 |
Number of pages | 6 |
Journal | Journal of Antibiotics |
Volume | 71 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2018 Feb 1 |
ASJC Scopus subject areas
- Pharmacology
- Drug Discovery