Hamuramicins A and B, 22-membered macrolides, produced by an endophytic actinomycete Allostreptomyces sp. K12-0794

Takuya Suga; Tōru Kimura; Yuki Inahashi; Masato Iwatsuki; Kenichi Nonaka; Akira Take; Atsuko Matsumoto; Yōko Takahashi; Satoshi Omura; Takuji Nakashima

doi:10.1038/s41429-018-0055-x

Hamuramicins A and B, 22-membered macrolides, produced by an endophytic actinomycete Allostreptomyces sp. K12-0794

Takuya Suga, Tōru Kimura, Yuki Inahashi, Masato Iwatsuki, Kenichi Nonaka, Akira Take, Atsuko Matsumoto, Yōko Takahashi, Satoshi Omura, Takuji Nakashima

Research output: Contribution to journal › Article

3 Citations (Scopus)

Abstract

Two new compounds, designated as hamuramicins A (1) and B (2), were isolated from the cultured broth of an endophytic actinomycete Allostreptomyces sp. K12-0794 by silica gel column chromatography and HPLC. The structures of 1 and 2 were elucidated as 22-membered macrolide containing triene and trienone with an alkyl side chain by spectroscopic analyses including NMR experiments. Both compounds showed growth inhibition activity against Kocuria rhizophia and Xanthomonas oryzae pv. oryzae as well as human cell line toxicity.

Original language	English
Pages (from-to)	619-625
Number of pages	7
Journal	Journal of Antibiotics
Volume	71
Issue number	7
DOIs	https://doi.org/10.1038/s41429-018-0055-x
Publication status	Published - 2018 Jul 1
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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Suga, T., Kimura, T., Inahashi, Y., Iwatsuki, M., Nonaka, K., Take, A., Matsumoto, A., Takahashi, Y., Omura, S., & Nakashima, T. (2018). Hamuramicins A and B, 22-membered macrolides, produced by an endophytic actinomycete Allostreptomyces sp. K12-0794. Journal of Antibiotics, 71(7), 619-625. https://doi.org/10.1038/s41429-018-0055-x

Hamuramicins A and B, 22-membered macrolides, produced by an endophytic actinomycete Allostreptomyces sp. K12-0794. / Suga, Takuya; Kimura, Tōru; Inahashi, Yuki; Iwatsuki, Masato; Nonaka, Kenichi; Take, Akira; Matsumoto, Atsuko; Takahashi, Yōko; Omura, Satoshi; Nakashima, Takuji.

In: Journal of Antibiotics, Vol. 71, No. 7, 01.07.2018, p. 619-625.

Research output: Contribution to journal › Article

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AU - Iwatsuki, Masato

AU - Nonaka, Kenichi

AU - Take, Akira

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AU - Omura, Satoshi

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