Abstract
Two new compounds, designated as hamuramicins A (1) and B (2), were isolated from the cultured broth of an endophytic actinomycete Allostreptomyces sp. K12-0794 by silica gel column chromatography and HPLC. The structures of 1 and 2 were elucidated as 22-membered macrolide containing triene and trienone with an alkyl side chain by spectroscopic analyses including NMR experiments. Both compounds showed growth inhibition activity against Kocuria rhizophia and Xanthomonas oryzae pv. oryzae as well as human cell line toxicity.
| Original language | English |
|---|---|
| Pages (from-to) | 619-625 |
| Number of pages | 7 |
| Journal | Journal of Antibiotics |
| Volume | 71 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2018 Jul 1 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pharmacology
- Drug Discovery
Cite this
Hamuramicins A and B, 22-membered macrolides, produced by an endophytic actinomycete Allostreptomyces sp. K12-0794. / Suga, Takuya; Kimura, Tōru; Inahashi, Yuki; Iwatsuki, Masato; Nonaka, Kenichi; Take, Akira; Matsumoto, Atsuko; Takahashi, Yōko; Omura, Satoshi; Nakashima, Takuji.
In: Journal of Antibiotics, Vol. 71, No. 7, 01.07.2018, p. 619-625.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Hamuramicins A and B, 22-membered macrolides, produced by an endophytic actinomycete Allostreptomyces sp. K12-0794
AU - Suga, Takuya
AU - Kimura, Tōru
AU - Inahashi, Yuki
AU - Iwatsuki, Masato
AU - Nonaka, Kenichi
AU - Take, Akira
AU - Matsumoto, Atsuko
AU - Takahashi, Yōko
AU - Omura, Satoshi
AU - Nakashima, Takuji
PY - 2018/7/1
Y1 - 2018/7/1
N2 - Two new compounds, designated as hamuramicins A (1) and B (2), were isolated from the cultured broth of an endophytic actinomycete Allostreptomyces sp. K12-0794 by silica gel column chromatography and HPLC. The structures of 1 and 2 were elucidated as 22-membered macrolide containing triene and trienone with an alkyl side chain by spectroscopic analyses including NMR experiments. Both compounds showed growth inhibition activity against Kocuria rhizophia and Xanthomonas oryzae pv. oryzae as well as human cell line toxicity.
AB - Two new compounds, designated as hamuramicins A (1) and B (2), were isolated from the cultured broth of an endophytic actinomycete Allostreptomyces sp. K12-0794 by silica gel column chromatography and HPLC. The structures of 1 and 2 were elucidated as 22-membered macrolide containing triene and trienone with an alkyl side chain by spectroscopic analyses including NMR experiments. Both compounds showed growth inhibition activity against Kocuria rhizophia and Xanthomonas oryzae pv. oryzae as well as human cell line toxicity.
UR - http://www.scopus.com/inward/record.url?scp=85045904460&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85045904460&partnerID=8YFLogxK
U2 - 10.1038/s41429-018-0055-x
DO - 10.1038/s41429-018-0055-x
M3 - Article
AN - SCOPUS:85045904460
VL - 71
SP - 619
EP - 625
JO - Journal of Antibiotics
JF - Journal of Antibiotics
SN - 0021-8820
IS - 7
ER -