Hamuramicins A and B, 22-membered macrolides, produced by an endophytic actinomycete Allostreptomyces sp. K12-0794

Takuya Suga, Tōru Kimura, Yuki Inahashi, Masato Iwatsuki, Kenichi Nonaka, Akira Take, Atsuko Matsumoto, Yōko Takahashi, Satoshi Omura, Takuji Nakashima

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Two new compounds, designated as hamuramicins A (1) and B (2), were isolated from the cultured broth of an endophytic actinomycete Allostreptomyces sp. K12-0794 by silica gel column chromatography and HPLC. The structures of 1 and 2 were elucidated as 22-membered macrolide containing triene and trienone with an alkyl side chain by spectroscopic analyses including NMR experiments. Both compounds showed growth inhibition activity against Kocuria rhizophia and Xanthomonas oryzae pv. oryzae as well as human cell line toxicity.

Original languageEnglish
Pages (from-to)619-625
Number of pages7
JournalJournal of Antibiotics
Volume71
Issue number7
DOIs
Publication statusPublished - 2018 Jul 1
Externally publishedYes

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Actinobacteria
Macrolides
Xanthomonas
Silica Gel
Gel Chromatography
High Pressure Liquid Chromatography
Cell Line
Growth
Oryza

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Suga, T., Kimura, T., Inahashi, Y., Iwatsuki, M., Nonaka, K., Take, A., ... Nakashima, T. (2018). Hamuramicins A and B, 22-membered macrolides, produced by an endophytic actinomycete Allostreptomyces sp. K12-0794. Journal of Antibiotics, 71(7), 619-625. https://doi.org/10.1038/s41429-018-0055-x

Hamuramicins A and B, 22-membered macrolides, produced by an endophytic actinomycete Allostreptomyces sp. K12-0794. / Suga, Takuya; Kimura, Tōru; Inahashi, Yuki; Iwatsuki, Masato; Nonaka, Kenichi; Take, Akira; Matsumoto, Atsuko; Takahashi, Yōko; Omura, Satoshi; Nakashima, Takuji.

In: Journal of Antibiotics, Vol. 71, No. 7, 01.07.2018, p. 619-625.

Research output: Contribution to journalArticle

Suga, T, Kimura, T, Inahashi, Y, Iwatsuki, M, Nonaka, K, Take, A, Matsumoto, A, Takahashi, Y, Omura, S & Nakashima, T 2018, 'Hamuramicins A and B, 22-membered macrolides, produced by an endophytic actinomycete Allostreptomyces sp. K12-0794', Journal of Antibiotics, vol. 71, no. 7, pp. 619-625. https://doi.org/10.1038/s41429-018-0055-x
Suga, Takuya ; Kimura, Tōru ; Inahashi, Yuki ; Iwatsuki, Masato ; Nonaka, Kenichi ; Take, Akira ; Matsumoto, Atsuko ; Takahashi, Yōko ; Omura, Satoshi ; Nakashima, Takuji. / Hamuramicins A and B, 22-membered macrolides, produced by an endophytic actinomycete Allostreptomyces sp. K12-0794. In: Journal of Antibiotics. 2018 ; Vol. 71, No. 7. pp. 619-625.
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