Helix-coil transition and 1/f fluctuation in a polypeptide

Mitsunori Takano, Takuya Takahashi, Kuniaki Nagayama

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

We report on molecular dynamics simulations of the helix-coil transition of a polypeptide. The simulated transition was two-state-like and similar to the solid-liquid-like transition that has been observed in computer simulations of an atomic cluster. At the transition temperature, the polypeptide chain fluctuated between a helical and a random-coil state, and we observed 1/f fluctuation through potential- energy fluctuations. The origin of the observed 1/f fluctuation is discussed, considering the underlying potential-energy landscape.

Original languageEnglish
Pages (from-to)5691-5694
Number of pages4
JournalPhysical Review Letters
Volume80
Issue number25
Publication statusPublished - 1998
Externally publishedYes

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polypeptides
helices
coils
potential energy
atomic clusters
computerized simulation
transition temperature
molecular dynamics
liquids
simulation

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Takano, M., Takahashi, T., & Nagayama, K. (1998). Helix-coil transition and 1/f fluctuation in a polypeptide. Physical Review Letters, 80(25), 5691-5694.

Helix-coil transition and 1/f fluctuation in a polypeptide. / Takano, Mitsunori; Takahashi, Takuya; Nagayama, Kuniaki.

In: Physical Review Letters, Vol. 80, No. 25, 1998, p. 5691-5694.

Research output: Contribution to journalArticle

Takano, M, Takahashi, T & Nagayama, K 1998, 'Helix-coil transition and 1/f fluctuation in a polypeptide', Physical Review Letters, vol. 80, no. 25, pp. 5691-5694.
Takano, Mitsunori ; Takahashi, Takuya ; Nagayama, Kuniaki. / Helix-coil transition and 1/f fluctuation in a polypeptide. In: Physical Review Letters. 1998 ; Vol. 80, No. 25. pp. 5691-5694.
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