Hemodynamic response with an artificial myocardial assistance in chronic animal examination

Y. Shiraishi, T. Yambe, Y. Saijo, M. Shibata, H. Liu, T. Sugai, A. Tanaka, S. Konno, A. Baba, T. Fujimoto, K. Imachi, M. Yoshizawa, S. Nitta, H. Sasada, K. Tabayashi, Y. Sato, M. Umezu, D. Homma

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Thromboembolic and haemorrhagic complications are the primary causes of mortality and morbidity in patients with artificial hearts, which are known to be induced by the interactions between blood flow and artificial material surfaces. The authors have been developing a new mechanical artificial myocardial assist device by using a sophisticated shape memory alloy fibre in order to achieve the mechanical cardiac support from outside of the heart without a direct blood contacting surface. The original material employed as the actuator of artificial myocardial assist devices was 100um fibred-shaped, which was composed of covalent and metallic bonding structure and designed to generate 4-7 % by Joule heating induced by the electric current input. Prior to the experiment, the myocardial streamlines were investigated by using a MDCT, and the design of artificial myocardial assist devices were refined based on the concept of Torrent-Guasp's myocardial band theory. As the hydrodynamic or hemodynamic examination exhibited the remarkable increase of cardiac systolic work by the assistance of the artificial myocardial contraction in the originally designed mock circulatory system as well as in the acute animal experiments, the chronic animal test has been started in a goat. Total weight of the device including the actuator was around 150g, and the electric power was supplied percutaneously. The device could be successfully installed into thoracic cavity, which was able to be girdling the left ventricle. In the chronic animal trial, the complication in respect to the diastolic dysfunction by the artificial myocardial compression was not observed. Systolic pressure and aortic flow waveforms were elevated by the assistance using the device contraction synchronously by around 5%. And blood pressure response against the increase of aortic pressure was investigated under the myocardial assisted condition in order to examine the vascular tone which was controlled by vagal nervous activity.

Original languageEnglish
Title of host publicationWorld Congress on Medical Physics and Biomedical Engineering
Subtitle of host publicationMicro- and Nanosystems in Medicine, Active Implants, Biosensors
Pages277-280
Number of pages4
Edition8
DOIs
Publication statusPublished - 2009
EventWorld Congress on Medical Physics and Biomedical Engineering: Micro- and Nanosystems in Medicine, Active Implants, Biosensors - Munich, Germany
Duration: 2009 Sep 72009 Sep 12

Publication series

NameIFMBE Proceedings
Number8
Volume25
ISSN (Print)1680-0737

Conference

ConferenceWorld Congress on Medical Physics and Biomedical Engineering: Micro- and Nanosystems in Medicine, Active Implants, Biosensors
CountryGermany
CityMunich
Period09/9/709/9/12

Keywords

  • Artificial myocardium
  • Blood pressure response
  • Chronic animal experiment
  • Hemodynamics
  • Myocardial band
  • Shape memory alloy fibre

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

Fingerprint Dive into the research topics of 'Hemodynamic response with an artificial myocardial assistance in chronic animal examination'. Together they form a unique fingerprint.

Cite this