Hemodynamic response with an artificial myocardial assistance in chronic animal examination

Y. Shiraishi, T. Yambe, Y. Saijo, M. Shibata, H. Liu, T. Sugai, A. Tanaka, S. Konno, A. Baba, T. Fujimoto, K. Imachi, M. Yoshizawa, S. Nitta, H. Sasada, K. Tabayashi, Y. Sato, Mitsuo Umezu, D. Homma

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Thromboembolic and haemorrhagic complications are the primary causes of mortality and morbidity in patients with artificial hearts, which are known to be induced by the interactions between blood flow and artificial material surfaces. The authors have been developing a new mechanical artificial myocardial assist device by using a sophisticated shape memory alloy fibre in order to achieve the mechanical cardiac support from outside of the heart without a direct blood contacting surface. The original material employed as the actuator of artificial myocardial assist devices was 100um fibred-shaped, which was composed of covalent and metallic bonding structure and designed to generate 4-7 % by Joule heating induced by the electric current input. Prior to the experiment, the myocardial streamlines were investigated by using a MDCT, and the design of artificial myocardial assist devices were refined based on the concept of Torrent-Guasp's myocardial band theory. As the hydrodynamic or hemodynamic examination exhibited the remarkable increase of cardiac systolic work by the assistance of the artificial myocardial contraction in the originally designed mock circulatory system as well as in the acute animal experiments, the chronic animal test has been started in a goat. Total weight of the device including the actuator was around 150g, and the electric power was supplied percutaneously. The device could be successfully installed into thoracic cavity, which was able to be girdling the left ventricle. In the chronic animal trial, the complication in respect to the diastolic dysfunction by the artificial myocardial compression was not observed. Systolic pressure and aortic flow waveforms were elevated by the assistance using the device contraction synchronously by around 5%. And blood pressure response against the increase of aortic pressure was investigated under the myocardial assisted condition in order to examine the vascular tone which was controlled by vagal nervous activity.

    Original languageEnglish
    Title of host publicationIFMBE Proceedings
    Pages277-280
    Number of pages4
    Volume25
    Edition8
    DOIs
    Publication statusPublished - 2009
    EventWorld Congress on Medical Physics and Biomedical Engineering: Micro- and Nanosystems in Medicine, Active Implants, Biosensors - Munich
    Duration: 2009 Sep 72009 Sep 12

    Other

    OtherWorld Congress on Medical Physics and Biomedical Engineering: Micro- and Nanosystems in Medicine, Active Implants, Biosensors
    CityMunich
    Period09/9/709/9/12

    Fingerprint

    Hemodynamics
    Animals
    Blood
    Actuators
    Artificial heart
    Joule heating
    Blood pressure
    Electric currents
    Shape memory effect
    Hydrodynamics
    Experiments
    Fibers

    Keywords

    • Artificial myocardium
    • Blood pressure response
    • Chronic animal experiment
    • Hemodynamics
    • Myocardial band
    • Shape memory alloy fibre

    ASJC Scopus subject areas

    • Biomedical Engineering
    • Bioengineering

    Cite this

    Shiraishi, Y., Yambe, T., Saijo, Y., Shibata, M., Liu, H., Sugai, T., ... Homma, D. (2009). Hemodynamic response with an artificial myocardial assistance in chronic animal examination. In IFMBE Proceedings (8 ed., Vol. 25, pp. 277-280) https://doi.org/10.1007/978-3-642-03887-7-80

    Hemodynamic response with an artificial myocardial assistance in chronic animal examination. / Shiraishi, Y.; Yambe, T.; Saijo, Y.; Shibata, M.; Liu, H.; Sugai, T.; Tanaka, A.; Konno, S.; Baba, A.; Fujimoto, T.; Imachi, K.; Yoshizawa, M.; Nitta, S.; Sasada, H.; Tabayashi, K.; Sato, Y.; Umezu, Mitsuo; Homma, D.

    IFMBE Proceedings. Vol. 25 8. ed. 2009. p. 277-280.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Shiraishi, Y, Yambe, T, Saijo, Y, Shibata, M, Liu, H, Sugai, T, Tanaka, A, Konno, S, Baba, A, Fujimoto, T, Imachi, K, Yoshizawa, M, Nitta, S, Sasada, H, Tabayashi, K, Sato, Y, Umezu, M & Homma, D 2009, Hemodynamic response with an artificial myocardial assistance in chronic animal examination. in IFMBE Proceedings. 8 edn, vol. 25, pp. 277-280, World Congress on Medical Physics and Biomedical Engineering: Micro- and Nanosystems in Medicine, Active Implants, Biosensors, Munich, 09/9/7. https://doi.org/10.1007/978-3-642-03887-7-80
    Shiraishi Y, Yambe T, Saijo Y, Shibata M, Liu H, Sugai T et al. Hemodynamic response with an artificial myocardial assistance in chronic animal examination. In IFMBE Proceedings. 8 ed. Vol. 25. 2009. p. 277-280 https://doi.org/10.1007/978-3-642-03887-7-80
    Shiraishi, Y. ; Yambe, T. ; Saijo, Y. ; Shibata, M. ; Liu, H. ; Sugai, T. ; Tanaka, A. ; Konno, S. ; Baba, A. ; Fujimoto, T. ; Imachi, K. ; Yoshizawa, M. ; Nitta, S. ; Sasada, H. ; Tabayashi, K. ; Sato, Y. ; Umezu, Mitsuo ; Homma, D. / Hemodynamic response with an artificial myocardial assistance in chronic animal examination. IFMBE Proceedings. Vol. 25 8. ed. 2009. pp. 277-280
    @inproceedings{8a8211ffbb6946dcadb09a6c9bd5068e,
    title = "Hemodynamic response with an artificial myocardial assistance in chronic animal examination",
    abstract = "Thromboembolic and haemorrhagic complications are the primary causes of mortality and morbidity in patients with artificial hearts, which are known to be induced by the interactions between blood flow and artificial material surfaces. The authors have been developing a new mechanical artificial myocardial assist device by using a sophisticated shape memory alloy fibre in order to achieve the mechanical cardiac support from outside of the heart without a direct blood contacting surface. The original material employed as the actuator of artificial myocardial assist devices was 100um fibred-shaped, which was composed of covalent and metallic bonding structure and designed to generate 4-7 {\%} by Joule heating induced by the electric current input. Prior to the experiment, the myocardial streamlines were investigated by using a MDCT, and the design of artificial myocardial assist devices were refined based on the concept of Torrent-Guasp's myocardial band theory. As the hydrodynamic or hemodynamic examination exhibited the remarkable increase of cardiac systolic work by the assistance of the artificial myocardial contraction in the originally designed mock circulatory system as well as in the acute animal experiments, the chronic animal test has been started in a goat. Total weight of the device including the actuator was around 150g, and the electric power was supplied percutaneously. The device could be successfully installed into thoracic cavity, which was able to be girdling the left ventricle. In the chronic animal trial, the complication in respect to the diastolic dysfunction by the artificial myocardial compression was not observed. Systolic pressure and aortic flow waveforms were elevated by the assistance using the device contraction synchronously by around 5{\%}. And blood pressure response against the increase of aortic pressure was investigated under the myocardial assisted condition in order to examine the vascular tone which was controlled by vagal nervous activity.",
    keywords = "Artificial myocardium, Blood pressure response, Chronic animal experiment, Hemodynamics, Myocardial band, Shape memory alloy fibre",
    author = "Y. Shiraishi and T. Yambe and Y. Saijo and M. Shibata and H. Liu and T. Sugai and A. Tanaka and S. Konno and A. Baba and T. Fujimoto and K. Imachi and M. Yoshizawa and S. Nitta and H. Sasada and K. Tabayashi and Y. Sato and Mitsuo Umezu and D. Homma",
    year = "2009",
    doi = "10.1007/978-3-642-03887-7-80",
    language = "English",
    isbn = "9783642038860",
    volume = "25",
    pages = "277--280",
    booktitle = "IFMBE Proceedings",
    edition = "8",

    }

    TY - GEN

    T1 - Hemodynamic response with an artificial myocardial assistance in chronic animal examination

    AU - Shiraishi, Y.

    AU - Yambe, T.

    AU - Saijo, Y.

    AU - Shibata, M.

    AU - Liu, H.

    AU - Sugai, T.

    AU - Tanaka, A.

    AU - Konno, S.

    AU - Baba, A.

    AU - Fujimoto, T.

    AU - Imachi, K.

    AU - Yoshizawa, M.

    AU - Nitta, S.

    AU - Sasada, H.

    AU - Tabayashi, K.

    AU - Sato, Y.

    AU - Umezu, Mitsuo

    AU - Homma, D.

    PY - 2009

    Y1 - 2009

    N2 - Thromboembolic and haemorrhagic complications are the primary causes of mortality and morbidity in patients with artificial hearts, which are known to be induced by the interactions between blood flow and artificial material surfaces. The authors have been developing a new mechanical artificial myocardial assist device by using a sophisticated shape memory alloy fibre in order to achieve the mechanical cardiac support from outside of the heart without a direct blood contacting surface. The original material employed as the actuator of artificial myocardial assist devices was 100um fibred-shaped, which was composed of covalent and metallic bonding structure and designed to generate 4-7 % by Joule heating induced by the electric current input. Prior to the experiment, the myocardial streamlines were investigated by using a MDCT, and the design of artificial myocardial assist devices were refined based on the concept of Torrent-Guasp's myocardial band theory. As the hydrodynamic or hemodynamic examination exhibited the remarkable increase of cardiac systolic work by the assistance of the artificial myocardial contraction in the originally designed mock circulatory system as well as in the acute animal experiments, the chronic animal test has been started in a goat. Total weight of the device including the actuator was around 150g, and the electric power was supplied percutaneously. The device could be successfully installed into thoracic cavity, which was able to be girdling the left ventricle. In the chronic animal trial, the complication in respect to the diastolic dysfunction by the artificial myocardial compression was not observed. Systolic pressure and aortic flow waveforms were elevated by the assistance using the device contraction synchronously by around 5%. And blood pressure response against the increase of aortic pressure was investigated under the myocardial assisted condition in order to examine the vascular tone which was controlled by vagal nervous activity.

    AB - Thromboembolic and haemorrhagic complications are the primary causes of mortality and morbidity in patients with artificial hearts, which are known to be induced by the interactions between blood flow and artificial material surfaces. The authors have been developing a new mechanical artificial myocardial assist device by using a sophisticated shape memory alloy fibre in order to achieve the mechanical cardiac support from outside of the heart without a direct blood contacting surface. The original material employed as the actuator of artificial myocardial assist devices was 100um fibred-shaped, which was composed of covalent and metallic bonding structure and designed to generate 4-7 % by Joule heating induced by the electric current input. Prior to the experiment, the myocardial streamlines were investigated by using a MDCT, and the design of artificial myocardial assist devices were refined based on the concept of Torrent-Guasp's myocardial band theory. As the hydrodynamic or hemodynamic examination exhibited the remarkable increase of cardiac systolic work by the assistance of the artificial myocardial contraction in the originally designed mock circulatory system as well as in the acute animal experiments, the chronic animal test has been started in a goat. Total weight of the device including the actuator was around 150g, and the electric power was supplied percutaneously. The device could be successfully installed into thoracic cavity, which was able to be girdling the left ventricle. In the chronic animal trial, the complication in respect to the diastolic dysfunction by the artificial myocardial compression was not observed. Systolic pressure and aortic flow waveforms were elevated by the assistance using the device contraction synchronously by around 5%. And blood pressure response against the increase of aortic pressure was investigated under the myocardial assisted condition in order to examine the vascular tone which was controlled by vagal nervous activity.

    KW - Artificial myocardium

    KW - Blood pressure response

    KW - Chronic animal experiment

    KW - Hemodynamics

    KW - Myocardial band

    KW - Shape memory alloy fibre

    UR - http://www.scopus.com/inward/record.url?scp=77949886411&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=77949886411&partnerID=8YFLogxK

    U2 - 10.1007/978-3-642-03887-7-80

    DO - 10.1007/978-3-642-03887-7-80

    M3 - Conference contribution

    SN - 9783642038860

    VL - 25

    SP - 277

    EP - 280

    BT - IFMBE Proceedings

    ER -