Hemodynamics of a functional centrifugal-flow total artificial heart with functional atrial contraction in goats

Takuya Shiga, Yasuyuki Shiraishi, Kyosuke Sano, Yasunori Taira, Yusuke Tsuboko, Akihiro Yamada, Hidekazu Miura, Shintaro Katahira, Masatoshi Akiyama, Yoshikatsu Saiki, Tomoyuki Yambe

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Implantation of a total artificial heart (TAH) is one of the therapeutic options for the treatment of patients with end-stage biventricular heart failure. There is no report on the hemodynamics of the functional centrifugal-flow TAH with functional atrial contraction (fCFTAH). We evaluated the effects of pulsatile flow by atrial contraction in acute animal models. The goats received fCFTAH that we created from two centrifugal-flow ventricular assist devices. Some hemodynamic parameters maintained acceptable levels: heart rate 115.5 ± 26.3 bpm, aortic pressure 83.5 ± 10.1 mmHg, left atrial pressure 18.0 ± 5.9 mmHg, pulmonary pressure 28.5 ± 9.7 mmHg, right atrial pressure 13.6 ± 5.2 mmHg, pump flow 4.0 ± 1.1 L/min (left) 3.9 ± 1.1 L/min (right), and cardiac index 2.13 ± 0.14 L/min/m2. fCFTAH with atrial contraction was able to maintain the TAH circulation by forming a pulsatile flow in acute animal experiments. Taking the left and right flow rate balance using the low internal pressure loss of the VAD pumps may be easier than by other pumps having considerable internal pressure loss. We showed that the remnant atrial contraction effected the flow rate change of the centrifugal pump, and the atrial contraction waves reflected the heart rate. These results indicate that remnant atria had the possibility to preserve autonomic function in fCFTAH. We may control fCFTAH by reflecting the autonomic function, which is estimated with the flow rate change of the centrifugal pump.

Original languageEnglish
Pages (from-to)8-13
Number of pages6
JournalJournal of Artificial Organs
Volume19
Issue number1
DOIs
Publication statusPublished - 2016 Mar 1
Externally publishedYes

Fingerprint

Artificial heart
Artificial Heart
Hemodynamics
Goats
Pulsatile Flow
Atrial Pressure
Pressure
Heart Rate
Pulsatile flow
Heart-Assist Devices
Centrifugal pumps
Flow rate
Pumps
Arterial Pressure
Animals
Animal Models
Heart Failure
Lung
Therapeutics

Keywords

  • Atrial contraction
  • Autonomic regulation
  • Centrifugal pump
  • Continuous flow
  • Total artificial heart

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering
  • Cardiology and Cardiovascular Medicine

Cite this

Hemodynamics of a functional centrifugal-flow total artificial heart with functional atrial contraction in goats. / Shiga, Takuya; Shiraishi, Yasuyuki; Sano, Kyosuke; Taira, Yasunori; Tsuboko, Yusuke; Yamada, Akihiro; Miura, Hidekazu; Katahira, Shintaro; Akiyama, Masatoshi; Saiki, Yoshikatsu; Yambe, Tomoyuki.

In: Journal of Artificial Organs, Vol. 19, No. 1, 01.03.2016, p. 8-13.

Research output: Contribution to journalArticle

Shiga, T, Shiraishi, Y, Sano, K, Taira, Y, Tsuboko, Y, Yamada, A, Miura, H, Katahira, S, Akiyama, M, Saiki, Y & Yambe, T 2016, 'Hemodynamics of a functional centrifugal-flow total artificial heart with functional atrial contraction in goats', Journal of Artificial Organs, vol. 19, no. 1, pp. 8-13. https://doi.org/10.1007/s10047-015-0852-y
Shiga, Takuya ; Shiraishi, Yasuyuki ; Sano, Kyosuke ; Taira, Yasunori ; Tsuboko, Yusuke ; Yamada, Akihiro ; Miura, Hidekazu ; Katahira, Shintaro ; Akiyama, Masatoshi ; Saiki, Yoshikatsu ; Yambe, Tomoyuki. / Hemodynamics of a functional centrifugal-flow total artificial heart with functional atrial contraction in goats. In: Journal of Artificial Organs. 2016 ; Vol. 19, No. 1. pp. 8-13.
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