Hemorrhagic shock resuscitation with an artificial oxygen carrier, hemoglobin vesicle, maintains intestinal perfusion and suppresses the increase in plasma tumor necrosis factor-α

Akira Yoshizu, Yotaro Izumi, Sungick Park, Hiromi Sakai, Shinji Takeoka, Hirohisa Horinouchi, Eiji Ikeda, Eishun Tsuchida, Koichi Kobayashi

    Research output: Contribution to journalArticle

    29 Citations (Scopus)

    Abstract

    It is known that damage to the intestinal mucosa followed by systemic inflammatory response is one of the leading causes of shock related morbidity and mortality. In this study, we examined the ability of an artificial oxygen carrier hemoglobin vesicle (HbV) to sustain systemic and intestinal perfusion during hemorrhagic shock. In rabbits, hemorrhagic shock (40% of the estimated blood volume) was resuscitated with 5% albumin (alb group), HbV suspended in 5% albumin (HbVaIb group), or washed red blood cells suspended in 5% albumin (RBCaIb group). Plasma tumor necrosis factor (TNF)-α level was measured in rats under the same experimental protocol. No significant intergroup differences were seen in systemic hemodynamics. In contrast, parameters of intestinal perfusion significantly deteriorated in the alb group but were equally well sustained in the HbVaIb and RBCaIb groups. Also, a significant increase in plasma TNF-α level was seen in the alb group but not in the RBCaIb or HbVaIb groups. These results indicate the proficient oxygen transporting capability of HbV and its potential efficacy in shock resuscitation.

    Original languageEnglish
    Pages (from-to)458-463
    Number of pages6
    JournalASAIO Journal
    Volume50
    Issue number5
    DOIs
    Publication statusPublished - 2004 Sep

    Fingerprint

    Resuscitation
    Hemorrhagic Shock
    Hemoglobin
    Albumins
    Hemoglobins
    Tumor Necrosis Factor-alpha
    Perfusion
    Oxygen
    Plasmas
    Shock
    Blood
    Hemodynamics
    Intestinal Mucosa
    Blood Volume
    Rats
    Erythrocytes
    Cells
    Rabbits
    Morbidity
    Mortality

    ASJC Scopus subject areas

    • Biophysics
    • Bioengineering

    Cite this

    Hemorrhagic shock resuscitation with an artificial oxygen carrier, hemoglobin vesicle, maintains intestinal perfusion and suppresses the increase in plasma tumor necrosis factor-α. / Yoshizu, Akira; Izumi, Yotaro; Park, Sungick; Sakai, Hiromi; Takeoka, Shinji; Horinouchi, Hirohisa; Ikeda, Eiji; Tsuchida, Eishun; Kobayashi, Koichi.

    In: ASAIO Journal, Vol. 50, No. 5, 09.2004, p. 458-463.

    Research output: Contribution to journalArticle

    Yoshizu, Akira ; Izumi, Yotaro ; Park, Sungick ; Sakai, Hiromi ; Takeoka, Shinji ; Horinouchi, Hirohisa ; Ikeda, Eiji ; Tsuchida, Eishun ; Kobayashi, Koichi. / Hemorrhagic shock resuscitation with an artificial oxygen carrier, hemoglobin vesicle, maintains intestinal perfusion and suppresses the increase in plasma tumor necrosis factor-α. In: ASAIO Journal. 2004 ; Vol. 50, No. 5. pp. 458-463.
    @article{88beaaf341184be9b41d06580b6d15a5,
    title = "Hemorrhagic shock resuscitation with an artificial oxygen carrier, hemoglobin vesicle, maintains intestinal perfusion and suppresses the increase in plasma tumor necrosis factor-α",
    abstract = "It is known that damage to the intestinal mucosa followed by systemic inflammatory response is one of the leading causes of shock related morbidity and mortality. In this study, we examined the ability of an artificial oxygen carrier hemoglobin vesicle (HbV) to sustain systemic and intestinal perfusion during hemorrhagic shock. In rabbits, hemorrhagic shock (40{\%} of the estimated blood volume) was resuscitated with 5{\%} albumin (alb group), HbV suspended in 5{\%} albumin (HbVaIb group), or washed red blood cells suspended in 5{\%} albumin (RBCaIb group). Plasma tumor necrosis factor (TNF)-α level was measured in rats under the same experimental protocol. No significant intergroup differences were seen in systemic hemodynamics. In contrast, parameters of intestinal perfusion significantly deteriorated in the alb group but were equally well sustained in the HbVaIb and RBCaIb groups. Also, a significant increase in plasma TNF-α level was seen in the alb group but not in the RBCaIb or HbVaIb groups. These results indicate the proficient oxygen transporting capability of HbV and its potential efficacy in shock resuscitation.",
    author = "Akira Yoshizu and Yotaro Izumi and Sungick Park and Hiromi Sakai and Shinji Takeoka and Hirohisa Horinouchi and Eiji Ikeda and Eishun Tsuchida and Koichi Kobayashi",
    year = "2004",
    month = "9",
    doi = "10.1097/01.MAT.0000136508.51676.EF",
    language = "English",
    volume = "50",
    pages = "458--463",
    journal = "ASAIO Journal",
    issn = "1058-2916",
    publisher = "Lippincott Williams and Wilkins",
    number = "5",

    }

    TY - JOUR

    T1 - Hemorrhagic shock resuscitation with an artificial oxygen carrier, hemoglobin vesicle, maintains intestinal perfusion and suppresses the increase in plasma tumor necrosis factor-α

    AU - Yoshizu, Akira

    AU - Izumi, Yotaro

    AU - Park, Sungick

    AU - Sakai, Hiromi

    AU - Takeoka, Shinji

    AU - Horinouchi, Hirohisa

    AU - Ikeda, Eiji

    AU - Tsuchida, Eishun

    AU - Kobayashi, Koichi

    PY - 2004/9

    Y1 - 2004/9

    N2 - It is known that damage to the intestinal mucosa followed by systemic inflammatory response is one of the leading causes of shock related morbidity and mortality. In this study, we examined the ability of an artificial oxygen carrier hemoglobin vesicle (HbV) to sustain systemic and intestinal perfusion during hemorrhagic shock. In rabbits, hemorrhagic shock (40% of the estimated blood volume) was resuscitated with 5% albumin (alb group), HbV suspended in 5% albumin (HbVaIb group), or washed red blood cells suspended in 5% albumin (RBCaIb group). Plasma tumor necrosis factor (TNF)-α level was measured in rats under the same experimental protocol. No significant intergroup differences were seen in systemic hemodynamics. In contrast, parameters of intestinal perfusion significantly deteriorated in the alb group but were equally well sustained in the HbVaIb and RBCaIb groups. Also, a significant increase in plasma TNF-α level was seen in the alb group but not in the RBCaIb or HbVaIb groups. These results indicate the proficient oxygen transporting capability of HbV and its potential efficacy in shock resuscitation.

    AB - It is known that damage to the intestinal mucosa followed by systemic inflammatory response is one of the leading causes of shock related morbidity and mortality. In this study, we examined the ability of an artificial oxygen carrier hemoglobin vesicle (HbV) to sustain systemic and intestinal perfusion during hemorrhagic shock. In rabbits, hemorrhagic shock (40% of the estimated blood volume) was resuscitated with 5% albumin (alb group), HbV suspended in 5% albumin (HbVaIb group), or washed red blood cells suspended in 5% albumin (RBCaIb group). Plasma tumor necrosis factor (TNF)-α level was measured in rats under the same experimental protocol. No significant intergroup differences were seen in systemic hemodynamics. In contrast, parameters of intestinal perfusion significantly deteriorated in the alb group but were equally well sustained in the HbVaIb and RBCaIb groups. Also, a significant increase in plasma TNF-α level was seen in the alb group but not in the RBCaIb or HbVaIb groups. These results indicate the proficient oxygen transporting capability of HbV and its potential efficacy in shock resuscitation.

    UR - http://www.scopus.com/inward/record.url?scp=4544360318&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=4544360318&partnerID=8YFLogxK

    U2 - 10.1097/01.MAT.0000136508.51676.EF

    DO - 10.1097/01.MAT.0000136508.51676.EF

    M3 - Article

    C2 - 15497385

    AN - SCOPUS:4544360318

    VL - 50

    SP - 458

    EP - 463

    JO - ASAIO Journal

    JF - ASAIO Journal

    SN - 1058-2916

    IS - 5

    ER -