Hepatocyte nuclear factor 1 beta induces transformation and epithelial-to-mesenchymal transition

Atsuka Matsui, Jiro Fujimoto, Kosuke Ishikawa, Emi Ito, Naoki Goshima, Shinya Watanabe, Kentaro Senba

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Abstract

    Gene amplification can be a cause of cancer, and driver oncogenes have been often identified in amplified regions. However, comprehensive analysis of other genes coamplified with an oncogene is rarely performed. We focused on the 17q12-21 amplicon, which contains ERBB2. We established a screening system for oncogenic activity with the NMuMG epithelial cell line. We identified a homeobox gene, HNF1B, as a novel cooperative transforming gene. HNF1B induced cancerous phenotypes, which were enhanced by the coexpression of ERBB2, and induced epithelial-to-mesenchymal transition and invasive phenotypes. These results suggest that HNF1B is a novel oncogene that can work cooperatively with ERBB2.

    Original languageEnglish
    Pages (from-to)1211-1221
    Number of pages11
    JournalFEBS Letters
    Volume590
    Issue number8
    DOIs
    Publication statusPublished - 2016 Apr 1

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    Keywords

    • breast tumor
    • epithelial-to-mesenchymal transition
    • gene amplification
    • hepatocyte nuclear factor 1 beta
    • three-dimensional culture

    ASJC Scopus subject areas

    • Biochemistry
    • Biophysics
    • Cell Biology
    • Genetics
    • Molecular Biology
    • Structural Biology

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