Hepatocyte nuclear factor 1 beta induces transformation and epithelial-to-mesenchymal transition

Atsuka Matsui; Jiro Fujimoto; Kosuke Ishikawa; Emi Ito; Naoki Goshima; Shinya Watanabe; Kentaro Semba

doi:10.1002/1873-3468.12147

Hepatocyte nuclear factor 1 beta induces transformation and epithelial-to-mesenchymal transition

Atsuka Matsui, Jiro Fujimoto, Kosuke Ishikawa, Emi Ito, Naoki Goshima, Shinya Watanabe, Kentaro Semba^*

^*Corresponding author for this work

School of Advanced Science and Engineering

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Gene amplification can be a cause of cancer, and driver oncogenes have been often identified in amplified regions. However, comprehensive analysis of other genes coamplified with an oncogene is rarely performed. We focused on the 17q12-21 amplicon, which contains ERBB2. We established a screening system for oncogenic activity with the NMuMG epithelial cell line. We identified a homeobox gene, HNF1B, as a novel cooperative transforming gene. HNF1B induced cancerous phenotypes, which were enhanced by the coexpression of ERBB2, and induced epithelial-to-mesenchymal transition and invasive phenotypes. These results suggest that HNF1B is a novel oncogene that can work cooperatively with ERBB2.

Original language	English
Pages (from-to)	1211-1221
Number of pages	11
Journal	FEBS Letters
Volume	590
Issue number	8
DOIs	https://doi.org/10.1002/1873-3468.12147
Publication status	Published - 2016 Apr 1

Keywords

breast tumor
epithelial-to-mesenchymal transition
gene amplification
hepatocyte nuclear factor 1 beta
three-dimensional culture

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/1873-3468.12147

Cite this

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title = "Hepatocyte nuclear factor 1 beta induces transformation and epithelial-to-mesenchymal transition",

abstract = "Gene amplification can be a cause of cancer, and driver oncogenes have been often identified in amplified regions. However, comprehensive analysis of other genes coamplified with an oncogene is rarely performed. We focused on the 17q12-21 amplicon, which contains ERBB2. We established a screening system for oncogenic activity with the NMuMG epithelial cell line. We identified a homeobox gene, HNF1B, as a novel cooperative transforming gene. HNF1B induced cancerous phenotypes, which were enhanced by the coexpression of ERBB2, and induced epithelial-to-mesenchymal transition and invasive phenotypes. These results suggest that HNF1B is a novel oncogene that can work cooperatively with ERBB2.",

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author = "Atsuka Matsui and Jiro Fujimoto and Kosuke Ishikawa and Emi Ito and Naoki Goshima and Shinya Watanabe and Kentaro Semba",

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doi = "10.1002/1873-3468.12147",

language = "English",

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T1 - Hepatocyte nuclear factor 1 beta induces transformation and epithelial-to-mesenchymal transition

AU - Matsui, Atsuka

AU - Fujimoto, Jiro

AU - Ishikawa, Kosuke

AU - Ito, Emi

AU - Goshima, Naoki

AU - Watanabe, Shinya

AU - Semba, Kentaro

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Gene amplification can be a cause of cancer, and driver oncogenes have been often identified in amplified regions. However, comprehensive analysis of other genes coamplified with an oncogene is rarely performed. We focused on the 17q12-21 amplicon, which contains ERBB2. We established a screening system for oncogenic activity with the NMuMG epithelial cell line. We identified a homeobox gene, HNF1B, as a novel cooperative transforming gene. HNF1B induced cancerous phenotypes, which were enhanced by the coexpression of ERBB2, and induced epithelial-to-mesenchymal transition and invasive phenotypes. These results suggest that HNF1B is a novel oncogene that can work cooperatively with ERBB2.

AB - Gene amplification can be a cause of cancer, and driver oncogenes have been often identified in amplified regions. However, comprehensive analysis of other genes coamplified with an oncogene is rarely performed. We focused on the 17q12-21 amplicon, which contains ERBB2. We established a screening system for oncogenic activity with the NMuMG epithelial cell line. We identified a homeobox gene, HNF1B, as a novel cooperative transforming gene. HNF1B induced cancerous phenotypes, which were enhanced by the coexpression of ERBB2, and induced epithelial-to-mesenchymal transition and invasive phenotypes. These results suggest that HNF1B is a novel oncogene that can work cooperatively with ERBB2.

KW - breast tumor

KW - epithelial-to-mesenchymal transition

KW - gene amplification

KW - hepatocyte nuclear factor 1 beta

KW - three-dimensional culture

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Hepatocyte nuclear factor 1 beta induces transformation and epithelial-to-mesenchymal transition

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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