Hepatocyte nuclear factor 1 beta induces transformation and epithelial-to-mesenchymal transition

Atsuka Matsui, Jiro Fujimoto, Kosuke Ishikawa, Emi Ito, Naoki Goshima, Shinya Watanabe, Kentaro Senba

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Abstract

    Gene amplification can be a cause of cancer, and driver oncogenes have been often identified in amplified regions. However, comprehensive analysis of other genes coamplified with an oncogene is rarely performed. We focused on the 17q12-21 amplicon, which contains ERBB2. We established a screening system for oncogenic activity with the NMuMG epithelial cell line. We identified a homeobox gene, HNF1B, as a novel cooperative transforming gene. HNF1B induced cancerous phenotypes, which were enhanced by the coexpression of ERBB2, and induced epithelial-to-mesenchymal transition and invasive phenotypes. These results suggest that HNF1B is a novel oncogene that can work cooperatively with ERBB2.

    Original languageEnglish
    Pages (from-to)1211-1221
    Number of pages11
    JournalFEBS Letters
    Volume590
    Issue number8
    DOIs
    Publication statusPublished - 2016 Apr 1

    Fingerprint

    Hepatocyte Nuclear Factor 1-beta
    Epithelial-Mesenchymal Transition
    Oncogenes
    Genes
    Phenotype
    Gene Amplification
    Homeobox Genes
    Screening
    Epithelial Cells
    Cell Line
    Neoplasms

    Keywords

    • breast tumor
    • epithelial-to-mesenchymal transition
    • gene amplification
    • hepatocyte nuclear factor 1 beta
    • three-dimensional culture

    ASJC Scopus subject areas

    • Biochemistry
    • Biophysics
    • Cell Biology
    • Genetics
    • Molecular Biology
    • Structural Biology

    Cite this

    Hepatocyte nuclear factor 1 beta induces transformation and epithelial-to-mesenchymal transition. / Matsui, Atsuka; Fujimoto, Jiro; Ishikawa, Kosuke; Ito, Emi; Goshima, Naoki; Watanabe, Shinya; Senba, Kentaro.

    In: FEBS Letters, Vol. 590, No. 8, 01.04.2016, p. 1211-1221.

    Research output: Contribution to journalArticle

    Matsui, A, Fujimoto, J, Ishikawa, K, Ito, E, Goshima, N, Watanabe, S & Senba, K 2016, 'Hepatocyte nuclear factor 1 beta induces transformation and epithelial-to-mesenchymal transition', FEBS Letters, vol. 590, no. 8, pp. 1211-1221. https://doi.org/10.1002/1873-3468.12147
    Matsui A, Fujimoto J, Ishikawa K, Ito E, Goshima N, Watanabe S et al. Hepatocyte nuclear factor 1 beta induces transformation and epithelial-to-mesenchymal transition. FEBS Letters. 2016 Apr 1;590(8):1211-1221. https://doi.org/10.1002/1873-3468.12147
    Matsui, Atsuka ; Fujimoto, Jiro ; Ishikawa, Kosuke ; Ito, Emi ; Goshima, Naoki ; Watanabe, Shinya ; Senba, Kentaro. / Hepatocyte nuclear factor 1 beta induces transformation and epithelial-to-mesenchymal transition. In: FEBS Letters. 2016 ; Vol. 590, No. 8. pp. 1211-1221.
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