Hepatocyte nuclear factor 1 beta induces transformation and epithelial-to-mesenchymal transition

Atsuka Matsui, Jiro Fujimoto, Kosuke Ishikawa, Emi Ito, Naoki Goshima, Shinya Watanabe, Kentaro Semba

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Gene amplification can be a cause of cancer, and driver oncogenes have been often identified in amplified regions. However, comprehensive analysis of other genes coamplified with an oncogene is rarely performed. We focused on the 17q12-21 amplicon, which contains ERBB2. We established a screening system for oncogenic activity with the NMuMG epithelial cell line. We identified a homeobox gene, HNF1B, as a novel cooperative transforming gene. HNF1B induced cancerous phenotypes, which were enhanced by the coexpression of ERBB2, and induced epithelial-to-mesenchymal transition and invasive phenotypes. These results suggest that HNF1B is a novel oncogene that can work cooperatively with ERBB2.

Original languageEnglish
Pages (from-to)1211-1221
Number of pages11
JournalFEBS Letters
Volume590
Issue number8
DOIs
Publication statusPublished - 2016 Apr 1

Keywords

  • breast tumor
  • epithelial-to-mesenchymal transition
  • gene amplification
  • hepatocyte nuclear factor 1 beta
  • three-dimensional culture

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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