High altitude and oxidative stress

Agoston Dosek, Hideko Ohno, Zoltan Acs, Albert W. Taylor, Zsolt Radak

Research output: Contribution to journalReview article

112 Citations (Scopus)

Abstract

Exposure to high altitude, which is associated with decreased oxygen pressure, could result in oxidative/reductive stress, enhanced generation of reactive oxygen and nitrogen species (RONS), and related oxidative damage to lipids, proteins, and DNA. The severity of oxidative challenge is related to the degree of altitude. A wide range of RONS generating systems are activated during exposure to high altitude, including the mitochondrial electron transport chain, xanthine oxidase, and nitric oxide synthase. High altitude appears to weaken the enzymatic and non-enzymatic antioxidant systems, and increased nutritional uptake of antioxidant vitamins are beneficial to reduce the altitude-induced oxidative damage. The pattern of high altitude exposure-associated oxidative damage resembles ischemia/reperfusion injury. The adaptive process to this oxidative challenge requires a relatively long period of time. Physical exercise or an enhanced level of physical activity at high altitude, exacerbates the extent of the oxidative challenge. Therefore, special attention is necessary to curb the degree of oxidative stress.

Original languageEnglish
Pages (from-to)128-131
Number of pages4
JournalRespiratory Physiology and Neurobiology
Volume158
Issue number2-3
DOIs
Publication statusPublished - 2007 Sep 30
Externally publishedYes

Fingerprint

Oxidative Stress
Reactive Nitrogen Species
Reactive Oxygen Species
Antioxidants
Xanthine Oxidase
Electron Transport
Reperfusion Injury
Vitamins
Nitric Oxide Synthase
Exercise
Oxygen
Lipids
Pressure
DNA
Proteins

Keywords

  • Acute mountain sickness
  • Antioxidants
  • High altitude
  • Oxidative damage
  • Oxidative stress
  • Reactive oxygen and nitrogen species

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Pulmonary and Respiratory Medicine

Cite this

High altitude and oxidative stress. / Dosek, Agoston; Ohno, Hideko; Acs, Zoltan; Taylor, Albert W.; Radak, Zsolt.

In: Respiratory Physiology and Neurobiology, Vol. 158, No. 2-3, 30.09.2007, p. 128-131.

Research output: Contribution to journalReview article

Dosek, Agoston ; Ohno, Hideko ; Acs, Zoltan ; Taylor, Albert W. ; Radak, Zsolt. / High altitude and oxidative stress. In: Respiratory Physiology and Neurobiology. 2007 ; Vol. 158, No. 2-3. pp. 128-131.
@article{8d3b224ae8e843819f88a97223023e17,
title = "High altitude and oxidative stress",
abstract = "Exposure to high altitude, which is associated with decreased oxygen pressure, could result in oxidative/reductive stress, enhanced generation of reactive oxygen and nitrogen species (RONS), and related oxidative damage to lipids, proteins, and DNA. The severity of oxidative challenge is related to the degree of altitude. A wide range of RONS generating systems are activated during exposure to high altitude, including the mitochondrial electron transport chain, xanthine oxidase, and nitric oxide synthase. High altitude appears to weaken the enzymatic and non-enzymatic antioxidant systems, and increased nutritional uptake of antioxidant vitamins are beneficial to reduce the altitude-induced oxidative damage. The pattern of high altitude exposure-associated oxidative damage resembles ischemia/reperfusion injury. The adaptive process to this oxidative challenge requires a relatively long period of time. Physical exercise or an enhanced level of physical activity at high altitude, exacerbates the extent of the oxidative challenge. Therefore, special attention is necessary to curb the degree of oxidative stress.",
keywords = "Acute mountain sickness, Antioxidants, High altitude, Oxidative damage, Oxidative stress, Reactive oxygen and nitrogen species",
author = "Agoston Dosek and Hideko Ohno and Zoltan Acs and Taylor, {Albert W.} and Zsolt Radak",
year = "2007",
month = "9",
day = "30",
doi = "10.1016/j.resp.2007.03.013",
language = "English",
volume = "158",
pages = "128--131",
journal = "Respiratory Physiology and Neurobiology",
issn = "1569-9048",
publisher = "Elsevier",
number = "2-3",

}

TY - JOUR

T1 - High altitude and oxidative stress

AU - Dosek, Agoston

AU - Ohno, Hideko

AU - Acs, Zoltan

AU - Taylor, Albert W.

AU - Radak, Zsolt

PY - 2007/9/30

Y1 - 2007/9/30

N2 - Exposure to high altitude, which is associated with decreased oxygen pressure, could result in oxidative/reductive stress, enhanced generation of reactive oxygen and nitrogen species (RONS), and related oxidative damage to lipids, proteins, and DNA. The severity of oxidative challenge is related to the degree of altitude. A wide range of RONS generating systems are activated during exposure to high altitude, including the mitochondrial electron transport chain, xanthine oxidase, and nitric oxide synthase. High altitude appears to weaken the enzymatic and non-enzymatic antioxidant systems, and increased nutritional uptake of antioxidant vitamins are beneficial to reduce the altitude-induced oxidative damage. The pattern of high altitude exposure-associated oxidative damage resembles ischemia/reperfusion injury. The adaptive process to this oxidative challenge requires a relatively long period of time. Physical exercise or an enhanced level of physical activity at high altitude, exacerbates the extent of the oxidative challenge. Therefore, special attention is necessary to curb the degree of oxidative stress.

AB - Exposure to high altitude, which is associated with decreased oxygen pressure, could result in oxidative/reductive stress, enhanced generation of reactive oxygen and nitrogen species (RONS), and related oxidative damage to lipids, proteins, and DNA. The severity of oxidative challenge is related to the degree of altitude. A wide range of RONS generating systems are activated during exposure to high altitude, including the mitochondrial electron transport chain, xanthine oxidase, and nitric oxide synthase. High altitude appears to weaken the enzymatic and non-enzymatic antioxidant systems, and increased nutritional uptake of antioxidant vitamins are beneficial to reduce the altitude-induced oxidative damage. The pattern of high altitude exposure-associated oxidative damage resembles ischemia/reperfusion injury. The adaptive process to this oxidative challenge requires a relatively long period of time. Physical exercise or an enhanced level of physical activity at high altitude, exacerbates the extent of the oxidative challenge. Therefore, special attention is necessary to curb the degree of oxidative stress.

KW - Acute mountain sickness

KW - Antioxidants

KW - High altitude

KW - Oxidative damage

KW - Oxidative stress

KW - Reactive oxygen and nitrogen species

UR - http://www.scopus.com/inward/record.url?scp=34548680780&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548680780&partnerID=8YFLogxK

U2 - 10.1016/j.resp.2007.03.013

DO - 10.1016/j.resp.2007.03.013

M3 - Review article

VL - 158

SP - 128

EP - 131

JO - Respiratory Physiology and Neurobiology

JF - Respiratory Physiology and Neurobiology

SN - 1569-9048

IS - 2-3

ER -