High-content analysis of single cells using a wide-field imaging sensor

T. Tanaka, T. Yoshino, Y. Maeda, T. Saeki, R. Negishi, R. Iwata, A. Kogiso, H. Dobashi, Tadashi Matsunaga

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Electrochemical sensing systems have been utilized in biosensors because it is easy to integrate the electrodes and electric circuits on miniaturized devices. In contrast, it was hard to integrate photo-sensing systems consisting of advanced optical components (e.g., condensing lenses and optical filters) in small devices due to the difficulties in miniaturization and cost-cutting of those optical components. However, recent efforts overcame this technical barrier, and thus a huge number of two-dimensional (2D) photosensors are equipped in digital cameras and smartphones, and widely used around the world. Technical development of such photosensors led to creation of novel biosensing systems enabling rapid, sensitive, and easy detection of biomolecules and microorganisms. This article summarized our recent achievement on wide-field imaging-based biosensors in which complementary metal oxide semiconductor (CMOS) image sensors were used for detection of various biological objects. In particular, high content analysis of single cells based on the developed photo-biosensing systems is introduced.

Original languageEnglish
Title of host publicationChemical Sensors 12
Subtitle of host publicationChemical and Biological Sensors and Analytical Systems
PublisherElectrochemical Society Inc.
Pages139-146
Number of pages8
Volume75
Edition16
ISBN (Electronic)9781607685395
DOIs
Publication statusPublished - 2016
Externally publishedYes
EventSymposium on Chemical Sensors 12: Chemical and Biological Sensors and Analytical Systems - PRiME 2016/230th ECS Meeting - Honolulu, United States
Duration: 2016 Oct 22016 Oct 7

Other

OtherSymposium on Chemical Sensors 12: Chemical and Biological Sensors and Analytical Systems - PRiME 2016/230th ECS Meeting
CountryUnited States
CityHonolulu
Period16/10/216/10/7

ASJC Scopus subject areas

  • Engineering(all)

Fingerprint Dive into the research topics of 'High-content analysis of single cells using a wide-field imaging sensor'. Together they form a unique fingerprint.

  • Cite this

    Tanaka, T., Yoshino, T., Maeda, Y., Saeki, T., Negishi, R., Iwata, R., Kogiso, A., Dobashi, H., & Matsunaga, T. (2016). High-content analysis of single cells using a wide-field imaging sensor. In Chemical Sensors 12: Chemical and Biological Sensors and Analytical Systems (16 ed., Vol. 75, pp. 139-146). Electrochemical Society Inc.. https://doi.org/10.1149/07516.0139ecst