High frequency activities in the human orbitofrontal cortex in sleep-wake cycle

Masaki Nishida, Sunao Uchida, Nobuhide Hirai, Fumikazu Miwakeichi, Taketoshi Maehara, Kensuke Kawai, Hiroyuki Shimizu, Satoshi Kato

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We recorded human orbitofrontal electrocorticogram during wakefulness and sleep in epileptic patients using subdural electrodes. During wakefulness and rapid eye movement (REM) sleep, we observed beta activity in the raw orbitofrontal signals. Power spectral analysis demonstrated beta enhancement during wakefulness and REM sleep when compared to slow wave sleep (SWS). During the phasic REM periods, the beta power was significantly lower than during the tonic REM periods. Gamma enhancement manifested itself in four out of six subjects during the phasic periods. This study is the first that has focused on electrical activity in the human orbitofrontal cortex. Although the role of the orbitofrontal cortex during sleep still remains unclear, high frequency activities give us important suggestions in elucidating the human sleep mechanism.

Original languageEnglish
Pages (from-to)110-115
Number of pages6
JournalNeuroscience Letters
Volume379
Issue number2
DOIs
Publication statusPublished - 2005 May 6

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Keywords

  • Beta/gamma activity
  • Electrocorticogram
  • Human
  • Orbitofrontal cortex
  • Tonic-phasic periods of REM sleep

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Nishida, M., Uchida, S., Hirai, N., Miwakeichi, F., Maehara, T., Kawai, K., Shimizu, H., & Kato, S. (2005). High frequency activities in the human orbitofrontal cortex in sleep-wake cycle. Neuroscience Letters, 379(2), 110-115. https://doi.org/10.1016/j.neulet.2004.12.069