High position resolution gamma-ray imagers consisting of a monolithic MPPC array with submillimeter pixelized scintillator crystals

Takuya Kato, Jun Kataoka, Takeshi Nakamori, Aya Kishimoto, Seiichi Yamamoto, Kenichi Sato, Yoshitake Ishikawa, Kazuhisa Yamamura, Sigeyuki Nakamura, Nobuyuki Kawabata, Hirokazu Ikeda, Kei Kamada

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    4 Citations (Scopus)

    Abstract

    We report on the development of two versatile, high spatial resolution gamma-ray imagers for medical imaging. One is a compact gamma-ray camera, the other is a tweezers type coincidence imaging system. These applications consisting of a large-area monolithic Multi-Pixel Photon Counter (MPPC) and submillimeter pixelized scintillator matrices. The MPPC array has 4×4 channels with a three-side buttable, very compact package. Each channel has a photosensitive area of 3×3 mm2 and 3600 Geiger mode avalanche photodiodes (APD). For a typical operational gain of 7.5×105 at + 20 degrees, gain fluctuation over the entire MPPC device is only ±5.6%, and dark count rates (as measured at the 1 p.e. level) amount to ≤400 kcps per channel. We particularly selected Ce-doped (Lu,Y) 2(SiO4)O (Ce:LYSO) and a brand-new scintillator, Ce-doped Gd3Al2Ga3O12 (Ce:GAGG) due to their high light yield and density. To improve the spatial resolution, these scintillators were fabricated to 22×22 or 15×15 matrices of 0.5×0.5 mm2 pixels. These scintillator matrices were coupled to the MPPC array with an acrylic light guide with 1 mm thick, and signals were read out using the charge division resistor network, which compiles signals into four position-encoded analog outputs. The spatial resolution of 1.2 mm was achieved with the compact gamma-ray camera using collimated 57Co source, and a radiography image of a bearing was successfully obtained. On the other hand, the spatial resolution of 1.1 mm was achieved with the coincidence imaging system using a 22Na source. Furthermore the experimental measurements for a PET scanner was performed, and the spatial resolution of 0.91 mm was achieved. These results suggest that the gamma-ray imagers has excellent potential for their uses as a high spatial medical imaging, and also be promising for positron emission tomography (PET).

    Original languageEnglish
    Title of host publicationIEEE Nuclear Science Symposium Conference Record
    Pages3146-3152
    Number of pages7
    DOIs
    Publication statusPublished - 2012
    Event2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2012 - Anaheim, CA
    Duration: 2012 Oct 292012 Nov 3

    Other

    Other2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2012
    CityAnaheim, CA
    Period12/10/2912/11/3

    Fingerprint

    Gamma Rays
    Photons
    scintillation counters
    counters
    spatial resolution
    pixels
    gamma rays
    Gamma Cameras
    photons
    Diagnostic Imaging
    Positron-Emission Tomography
    crystals
    Avalanches
    positrons
    Light
    matrices
    tomography
    cameras
    Radiography
    radiography

    ASJC Scopus subject areas

    • Radiation
    • Nuclear and High Energy Physics
    • Radiology Nuclear Medicine and imaging

    Cite this

    Kato, T., Kataoka, J., Nakamori, T., Kishimoto, A., Yamamoto, S., Sato, K., ... Kamada, K. (2012). High position resolution gamma-ray imagers consisting of a monolithic MPPC array with submillimeter pixelized scintillator crystals. In IEEE Nuclear Science Symposium Conference Record (pp. 3146-3152). [6551718] https://doi.org/10.1109/NSSMIC.2012.6551718

    High position resolution gamma-ray imagers consisting of a monolithic MPPC array with submillimeter pixelized scintillator crystals. / Kato, Takuya; Kataoka, Jun; Nakamori, Takeshi; Kishimoto, Aya; Yamamoto, Seiichi; Sato, Kenichi; Ishikawa, Yoshitake; Yamamura, Kazuhisa; Nakamura, Sigeyuki; Kawabata, Nobuyuki; Ikeda, Hirokazu; Kamada, Kei.

    IEEE Nuclear Science Symposium Conference Record. 2012. p. 3146-3152 6551718.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Kato, T, Kataoka, J, Nakamori, T, Kishimoto, A, Yamamoto, S, Sato, K, Ishikawa, Y, Yamamura, K, Nakamura, S, Kawabata, N, Ikeda, H & Kamada, K 2012, High position resolution gamma-ray imagers consisting of a monolithic MPPC array with submillimeter pixelized scintillator crystals. in IEEE Nuclear Science Symposium Conference Record., 6551718, pp. 3146-3152, 2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2012, Anaheim, CA, 12/10/29. https://doi.org/10.1109/NSSMIC.2012.6551718
    Kato T, Kataoka J, Nakamori T, Kishimoto A, Yamamoto S, Sato K et al. High position resolution gamma-ray imagers consisting of a monolithic MPPC array with submillimeter pixelized scintillator crystals. In IEEE Nuclear Science Symposium Conference Record. 2012. p. 3146-3152. 6551718 https://doi.org/10.1109/NSSMIC.2012.6551718
    Kato, Takuya ; Kataoka, Jun ; Nakamori, Takeshi ; Kishimoto, Aya ; Yamamoto, Seiichi ; Sato, Kenichi ; Ishikawa, Yoshitake ; Yamamura, Kazuhisa ; Nakamura, Sigeyuki ; Kawabata, Nobuyuki ; Ikeda, Hirokazu ; Kamada, Kei. / High position resolution gamma-ray imagers consisting of a monolithic MPPC array with submillimeter pixelized scintillator crystals. IEEE Nuclear Science Symposium Conference Record. 2012. pp. 3146-3152
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    abstract = "We report on the development of two versatile, high spatial resolution gamma-ray imagers for medical imaging. One is a compact gamma-ray camera, the other is a tweezers type coincidence imaging system. These applications consisting of a large-area monolithic Multi-Pixel Photon Counter (MPPC) and submillimeter pixelized scintillator matrices. The MPPC array has 4×4 channels with a three-side buttable, very compact package. Each channel has a photosensitive area of 3×3 mm2 and 3600 Geiger mode avalanche photodiodes (APD). For a typical operational gain of 7.5×105 at + 20 degrees, gain fluctuation over the entire MPPC device is only ±5.6{\%}, and dark count rates (as measured at the 1 p.e. level) amount to ≤400 kcps per channel. We particularly selected Ce-doped (Lu,Y) 2(SiO4)O (Ce:LYSO) and a brand-new scintillator, Ce-doped Gd3Al2Ga3O12 (Ce:GAGG) due to their high light yield and density. To improve the spatial resolution, these scintillators were fabricated to 22×22 or 15×15 matrices of 0.5×0.5 mm2 pixels. These scintillator matrices were coupled to the MPPC array with an acrylic light guide with 1 mm thick, and signals were read out using the charge division resistor network, which compiles signals into four position-encoded analog outputs. The spatial resolution of 1.2 mm was achieved with the compact gamma-ray camera using collimated 57Co source, and a radiography image of a bearing was successfully obtained. On the other hand, the spatial resolution of 1.1 mm was achieved with the coincidence imaging system using a 22Na source. Furthermore the experimental measurements for a PET scanner was performed, and the spatial resolution of 0.91 mm was achieved. These results suggest that the gamma-ray imagers has excellent potential for their uses as a high spatial medical imaging, and also be promising for positron emission tomography (PET).",
    author = "Takuya Kato and Jun Kataoka and Takeshi Nakamori and Aya Kishimoto and Seiichi Yamamoto and Kenichi Sato and Yoshitake Ishikawa and Kazuhisa Yamamura and Sigeyuki Nakamura and Nobuyuki Kawabata and Hirokazu Ikeda and Kei Kamada",
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    AU - Yamamoto, Seiichi

    AU - Sato, Kenichi

    AU - Ishikawa, Yoshitake

    AU - Yamamura, Kazuhisa

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    AU - Kawabata, Nobuyuki

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