High-precision compton imaging of 4.4 MeV prompt gamma-ray toward an on-line monitor for proton therapy

S. Mochizuki, Jun Kataoka, A. Koide, K. Fujieda, T. Maruhashi, T. Kurihara, K. Sueoka, L. Tagawa, M. Yoneyama, T. Inaniwa

    Research output: Contribution to journalArticle

    Abstract

    Proton therapy is a widely used and effective treatment for cancer. A high-dose concentration of proton beam reduces damage to normal tissues. However, it also requires a high accuracy of irradiation. PET is generally used to verify the proton range after irradiation, but, the distributions of positrons and the energy deposited by protons are not similar to each other. Recently, prompt gamma-ray imaging has attracted attention as a new, online imaging technique. In particular, 4.4 MeV gamma rays emitted from 12C* is one of the best probes to monitor the proton dose, however imaging techniques are far from established. We have developed a novel, 3-D position sensitive Compton camera based on Ce:GAGG scintillators coupled with multi-pixel photon counter (MPPC) arrays, thus making it optimized for imaging in the 1–10 MeV range. The angular resolution is 5 degrees (FWHM) at 4.4 MeV. We have established various methods to discriminate multiple-Compton and escape events, both of which can be critical backgrounds for precise imaging of prompt gamma rays. By irradiating a 70 MeV proton beam on the PMMA phantom, we demonstrated that 4.4 MeV gamma ray image is sharply concentrated on the Bragg peak, as was expected from the PHITS simulation.

    Fingerprint

    Gamma rays
    monitors
    therapy
    Protons
    gamma rays
    Imaging techniques
    protons
    proton beams
    imaging techniques
    Proton beams
    dosage
    irradiation
    Irradiation
    angular resolution
    scintillation counters
    escape
    Positrons
    positrons
    counters
    Full width at half maximum

    Keywords

    • Compton camera
    • MPPC
    • Prompt gamma-ray imaging
    • Proton therapy

    ASJC Scopus subject areas

    • Nuclear and High Energy Physics
    • Instrumentation

    Cite this

    High-precision compton imaging of 4.4 MeV prompt gamma-ray toward an on-line monitor for proton therapy. / Mochizuki, S.; Kataoka, Jun; Koide, A.; Fujieda, K.; Maruhashi, T.; Kurihara, T.; Sueoka, K.; Tagawa, L.; Yoneyama, M.; Inaniwa, T.

    In: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 01.01.2018.

    Research output: Contribution to journalArticle

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    abstract = "Proton therapy is a widely used and effective treatment for cancer. A high-dose concentration of proton beam reduces damage to normal tissues. However, it also requires a high accuracy of irradiation. PET is generally used to verify the proton range after irradiation, but, the distributions of positrons and the energy deposited by protons are not similar to each other. Recently, prompt gamma-ray imaging has attracted attention as a new, online imaging technique. In particular, 4.4 MeV gamma rays emitted from 12C* is one of the best probes to monitor the proton dose, however imaging techniques are far from established. We have developed a novel, 3-D position sensitive Compton camera based on Ce:GAGG scintillators coupled with multi-pixel photon counter (MPPC) arrays, thus making it optimized for imaging in the 1–10 MeV range. The angular resolution is 5 degrees (FWHM) at 4.4 MeV. We have established various methods to discriminate multiple-Compton and escape events, both of which can be critical backgrounds for precise imaging of prompt gamma rays. By irradiating a 70 MeV proton beam on the PMMA phantom, we demonstrated that 4.4 MeV gamma ray image is sharply concentrated on the Bragg peak, as was expected from the PHITS simulation.",
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    AU - Mochizuki, S.

    AU - Kataoka, Jun

    AU - Koide, A.

    AU - Fujieda, K.

    AU - Maruhashi, T.

    AU - Kurihara, T.

    AU - Sueoka, K.

    AU - Tagawa, L.

    AU - Yoneyama, M.

    AU - Inaniwa, T.

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