High priority of nanocrystalline diamond as a biosensing platform

Xianfen Wang, Shinichiro Kurihara, Masataka Hasegawa, A. Rahim Ruslinda, Hiroshi Kawarada

    Research output: Contribution to journalArticle

    3 Citations (Scopus)

    Abstract

    Here we report the performance of surface functionalized diamond surfaces as biosensing platform for human immunodeficiency virus transactivator of transcription (HIV-Tat) peptide detection. Comparative investigations were conducted on nanocrystalline diamond (NCD) and polycrystalline diamond (PCD) films. Scanning electron microscopy (SEM) images revealed the morphology differences between NCD and PCD films. X-ray photoelectron spectroscopy (XPS) data showed that functional components and corresponding coverages, demonstrating denser carboxyl acid groups and fluorinated groups on NCD than that PCD films after UV/ozone and fluorine plasma treatment respectively. Contact angle results showed the differences in surface wettability and free energy between functionalized NCD and PCD biosensors. Fluorescence observations confirmed that higher biosensing performance can be obtained on NCD biosensors with high sensitivity selectivity, and stability. The NCD films with denser surface coverages of functionalizations made NCD films much more priority as an effective biosensing candidate than PCD films.

    Original languageEnglish
    Article number090125
    JournalJapanese Journal of Applied Physics
    Volume51
    Issue number9
    DOIs
    Publication statusPublished - 2012 Sep

    Fingerprint

    Diamond films
    diamond films
    Diamonds
    platforms
    diamonds
    bioinstrumentation
    Biosensors
    human immunodeficiency virus
    Transcription
    wettability
    Viruses
    Fluorine
    Ozone
    Peptides
    Free energy
    ozone
    Contact angle
    peptides
    fluorine
    Wetting

    ASJC Scopus subject areas

    • Engineering(all)
    • Physics and Astronomy(all)

    Cite this

    High priority of nanocrystalline diamond as a biosensing platform. / Wang, Xianfen; Kurihara, Shinichiro; Hasegawa, Masataka; Ruslinda, A. Rahim; Kawarada, Hiroshi.

    In: Japanese Journal of Applied Physics, Vol. 51, No. 9, 090125, 09.2012.

    Research output: Contribution to journalArticle

    Wang, Xianfen ; Kurihara, Shinichiro ; Hasegawa, Masataka ; Ruslinda, A. Rahim ; Kawarada, Hiroshi. / High priority of nanocrystalline diamond as a biosensing platform. In: Japanese Journal of Applied Physics. 2012 ; Vol. 51, No. 9.
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