High speed organelles sorting microsystem driven by a single pressure source

Tokihiko Aoki, Yoshitaka Shirasaki, Takahiro Arakawa, Hirokazu Sugino, Takashi Funatsu, Shuichi Shoji

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

High performance biomolecules sorting microsystem was realized using the thermosensitive hydrogel (block copolymer of poly N-isopropylacrylamide and poly oxyethylene: Mebiol GelTM). High speed switching of about 5 msec was performed by the 3-D sheath flow and flow resistance change caused by the sol-gel transfrormation of the hydrogel with the focused infrared (IR) laser. Considering the actual applications, the microchannel structure was designed to control sample and carriers with only one pressure source. 1.5 millions of mitochondria were successfully separated by this system with accuracy of more than 92.5 % during 60 hours.

Original languageEnglish
Title of host publicationProceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
EditorsJean-Louis Viovy, Patrick Tabeling, Stephanie Descroix, Laurent Malaquin
PublisherChemical and Biological Microsystems Society
Pages224-226
Number of pages3
ISBN (Electronic)9780979806407
Publication statusPublished - 2007
Event11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 - Paris, France
Duration: 2007 Oct 72007 Oct 11

Publication series

NameProceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007

Conference

Conference11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
CountryFrance
CityParis
Period07/10/707/10/11

Keywords

  • 3-D Sheath Flow
  • High Speed Sorter
  • Mitochondria Separation
  • Organelle Sorter

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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