Higher cardiorespiratory fitness attenuates arterial stiffening associated with the Ala54Thr polymorphism in FABP2

Shumpei Fujie, Motoyuki Iemitsu, Haruka Murakami, Kiyoshi Sanada, Hiroshi Kawano, Yuko Gando, Ryoko Kawakami, Motohiko Miyachi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Fatty acid binding protein 2 (FABP2) Ala54Thr polymorphism is a candidate gene associated with the risk of cardiovascular disease. Habitual exercise brings higher cardiorespiratory fitness and results in the improvement of cardiovascular disease risk. However, the effect of cardiorespiratory fitness level and FABP2 Ala54Thr polymorphism on the risk of cardiovascular diseases remains unclear. In the present study, a cross-sectional investigation of 837 Japanese men and women was performed to clarify the effects of cardiorespiratory fitness on the relationship between risk of cardiovascular disease and FABP2 Ala54Thr gene polymorphism. The study subjects were divided into high-cardiorespiratory fitness (High-Fit) and low-cardiorespiratory fitness (Low-Fit) groups based on the median value of peak oxygen uptake in each sex and decade. The FABP2 Ala54Thr polymorphism did not significantly affect carotid β-stiffness or blood pressure. In the Low-Fit group, carotid β-stiffness, systolic blood pressure, and diastolic blood pressure were higher for individuals with the Ala/Ala genotype compared with those with the Ala/Thr or Thr/Thr genotype, whereas no differences were observed in the High-Fit group. Additionally, serum triglyceride and plasma glucose levels were lower and serum high-density lipoprotein cholesterol levels were higher in the High-Fit group compared with the Low-Fit group; the FABP2 Ala54Thr polymorphism did not significantly affect these parameters. These results suggest that the higher cardiorespiratory fitness may attenuate the changes in central arterial stiffness and blood pressure that are associated with the FABP2 genotype.

Original languageEnglish
Pages (from-to)237-242
Number of pages6
JournalPhysiological Genomics
Volume45
Issue number6
DOIs
Publication statusPublished - 2013

Fingerprint

Fatty Acid-Binding Proteins
Blood Pressure
Cardiovascular Diseases
Genotype
Cardiorespiratory Fitness
Vascular Stiffness
Serum
HDL Cholesterol
Genes
Arterial Pressure
Triglycerides
Exercise
Oxygen
Glucose

Keywords

  • Arteriosclerosis
  • Diastolic blood pressure
  • Peak oxygen uptake
  • Systolic blood pressure

ASJC Scopus subject areas

  • Physiology
  • Genetics

Cite this

Higher cardiorespiratory fitness attenuates arterial stiffening associated with the Ala54Thr polymorphism in FABP2. / Fujie, Shumpei; Iemitsu, Motoyuki; Murakami, Haruka; Sanada, Kiyoshi; Kawano, Hiroshi; Gando, Yuko; Kawakami, Ryoko; Miyachi, Motohiko.

In: Physiological Genomics, Vol. 45, No. 6, 2013, p. 237-242.

Research output: Contribution to journalArticle

Fujie, Shumpei ; Iemitsu, Motoyuki ; Murakami, Haruka ; Sanada, Kiyoshi ; Kawano, Hiroshi ; Gando, Yuko ; Kawakami, Ryoko ; Miyachi, Motohiko. / Higher cardiorespiratory fitness attenuates arterial stiffening associated with the Ala54Thr polymorphism in FABP2. In: Physiological Genomics. 2013 ; Vol. 45, No. 6. pp. 237-242.
@article{e819d6c9808841589d3b1b7c3591f516,
title = "Higher cardiorespiratory fitness attenuates arterial stiffening associated with the Ala54Thr polymorphism in FABP2",
abstract = "Fatty acid binding protein 2 (FABP2) Ala54Thr polymorphism is a candidate gene associated with the risk of cardiovascular disease. Habitual exercise brings higher cardiorespiratory fitness and results in the improvement of cardiovascular disease risk. However, the effect of cardiorespiratory fitness level and FABP2 Ala54Thr polymorphism on the risk of cardiovascular diseases remains unclear. In the present study, a cross-sectional investigation of 837 Japanese men and women was performed to clarify the effects of cardiorespiratory fitness on the relationship between risk of cardiovascular disease and FABP2 Ala54Thr gene polymorphism. The study subjects were divided into high-cardiorespiratory fitness (High-Fit) and low-cardiorespiratory fitness (Low-Fit) groups based on the median value of peak oxygen uptake in each sex and decade. The FABP2 Ala54Thr polymorphism did not significantly affect carotid β-stiffness or blood pressure. In the Low-Fit group, carotid β-stiffness, systolic blood pressure, and diastolic blood pressure were higher for individuals with the Ala/Ala genotype compared with those with the Ala/Thr or Thr/Thr genotype, whereas no differences were observed in the High-Fit group. Additionally, serum triglyceride and plasma glucose levels were lower and serum high-density lipoprotein cholesterol levels were higher in the High-Fit group compared with the Low-Fit group; the FABP2 Ala54Thr polymorphism did not significantly affect these parameters. These results suggest that the higher cardiorespiratory fitness may attenuate the changes in central arterial stiffness and blood pressure that are associated with the FABP2 genotype.",
keywords = "Arteriosclerosis, Diastolic blood pressure, Peak oxygen uptake, Systolic blood pressure",
author = "Shumpei Fujie and Motoyuki Iemitsu and Haruka Murakami and Kiyoshi Sanada and Hiroshi Kawano and Yuko Gando and Ryoko Kawakami and Motohiko Miyachi",
year = "2013",
doi = "10.1152/physiolgenomics.00089.2012",
language = "English",
volume = "45",
pages = "237--242",
journal = "Physiological Genomics",
issn = "1094-8341",
publisher = "American Physiological Society",
number = "6",

}

TY - JOUR

T1 - Higher cardiorespiratory fitness attenuates arterial stiffening associated with the Ala54Thr polymorphism in FABP2

AU - Fujie, Shumpei

AU - Iemitsu, Motoyuki

AU - Murakami, Haruka

AU - Sanada, Kiyoshi

AU - Kawano, Hiroshi

AU - Gando, Yuko

AU - Kawakami, Ryoko

AU - Miyachi, Motohiko

PY - 2013

Y1 - 2013

N2 - Fatty acid binding protein 2 (FABP2) Ala54Thr polymorphism is a candidate gene associated with the risk of cardiovascular disease. Habitual exercise brings higher cardiorespiratory fitness and results in the improvement of cardiovascular disease risk. However, the effect of cardiorespiratory fitness level and FABP2 Ala54Thr polymorphism on the risk of cardiovascular diseases remains unclear. In the present study, a cross-sectional investigation of 837 Japanese men and women was performed to clarify the effects of cardiorespiratory fitness on the relationship between risk of cardiovascular disease and FABP2 Ala54Thr gene polymorphism. The study subjects were divided into high-cardiorespiratory fitness (High-Fit) and low-cardiorespiratory fitness (Low-Fit) groups based on the median value of peak oxygen uptake in each sex and decade. The FABP2 Ala54Thr polymorphism did not significantly affect carotid β-stiffness or blood pressure. In the Low-Fit group, carotid β-stiffness, systolic blood pressure, and diastolic blood pressure were higher for individuals with the Ala/Ala genotype compared with those with the Ala/Thr or Thr/Thr genotype, whereas no differences were observed in the High-Fit group. Additionally, serum triglyceride and plasma glucose levels were lower and serum high-density lipoprotein cholesterol levels were higher in the High-Fit group compared with the Low-Fit group; the FABP2 Ala54Thr polymorphism did not significantly affect these parameters. These results suggest that the higher cardiorespiratory fitness may attenuate the changes in central arterial stiffness and blood pressure that are associated with the FABP2 genotype.

AB - Fatty acid binding protein 2 (FABP2) Ala54Thr polymorphism is a candidate gene associated with the risk of cardiovascular disease. Habitual exercise brings higher cardiorespiratory fitness and results in the improvement of cardiovascular disease risk. However, the effect of cardiorespiratory fitness level and FABP2 Ala54Thr polymorphism on the risk of cardiovascular diseases remains unclear. In the present study, a cross-sectional investigation of 837 Japanese men and women was performed to clarify the effects of cardiorespiratory fitness on the relationship between risk of cardiovascular disease and FABP2 Ala54Thr gene polymorphism. The study subjects were divided into high-cardiorespiratory fitness (High-Fit) and low-cardiorespiratory fitness (Low-Fit) groups based on the median value of peak oxygen uptake in each sex and decade. The FABP2 Ala54Thr polymorphism did not significantly affect carotid β-stiffness or blood pressure. In the Low-Fit group, carotid β-stiffness, systolic blood pressure, and diastolic blood pressure were higher for individuals with the Ala/Ala genotype compared with those with the Ala/Thr or Thr/Thr genotype, whereas no differences were observed in the High-Fit group. Additionally, serum triglyceride and plasma glucose levels were lower and serum high-density lipoprotein cholesterol levels were higher in the High-Fit group compared with the Low-Fit group; the FABP2 Ala54Thr polymorphism did not significantly affect these parameters. These results suggest that the higher cardiorespiratory fitness may attenuate the changes in central arterial stiffness and blood pressure that are associated with the FABP2 genotype.

KW - Arteriosclerosis

KW - Diastolic blood pressure

KW - Peak oxygen uptake

KW - Systolic blood pressure

UR - http://www.scopus.com/inward/record.url?scp=84878625736&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878625736&partnerID=8YFLogxK

U2 - 10.1152/physiolgenomics.00089.2012

DO - 10.1152/physiolgenomics.00089.2012

M3 - Article

C2 - 23362142

AN - SCOPUS:84878625736

VL - 45

SP - 237

EP - 242

JO - Physiological Genomics

JF - Physiological Genomics

SN - 1094-8341

IS - 6

ER -