Higher cardiorespiratory fitness attenuates the risk of atherosclerosis associated with ADRB3 Trp64Arg polymorphism

Motoyuki Iemitsu, Shumpei Fujie, Haruka Murakami, Kiyoshi Sanada, Hiroshi Kawano, Yuko Gando, Ryoko Kawakami, Noriko Tanaka, Motohiko Miyachi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: β3-Adrenergic receptor (ADRB3) Trp64Arg polymorphism is associated with atherogenic risk factors that include weight gain, insulin resistance, and diabetes. Habitual exercise brings higher cardiorespiratory fitness and results in the amelioration of atherosclerotic risk factors. However, the effects of cardiorespiratory fitness level and ADRB3 Trp64Arg polymorphism on the risk of cardiovascular disease remain unclear. A cross-sectional investigation of 877 Japanese men and women (18-75 years old) was performed to clarify the effects of cardiorespiratory fitness on the relationship between ADRB3 Trp64Arg polymorphism and risk of cardiovascular disease. Method: Common carotid intima-media thickness (ccIMT) and blood lipid profiles were assessed as surrogate markers of atherosclerosis. We measured peak oxygen uptake (V ̇ O2peak) during incremental cycle ergometer exercise testing. Subjects were divided into groups with high (High-Fit) and low (Low-Fit) levels of cardiorespiratory fitness based on the median value of V ̇ O2peak for sex and decade. Results: Levels of body fat, triglycerides, and plasma glucose were lower and high-density lipoprotein cholesterol levels and V ̇ O2peak were higher in High-Fit subjects than Low-Fit subjects. ADRB3 Trp64Arg polymorphism did not significantly affect ccIMT or blood lipid profiles. In Low-Fit subjects, ccIMT was higher in individuals with the Arg/Arg genotype compared to the Trp/Trp and Trp/Arg genotypes (each P < 0.0001); however, ADRB3 polymorphism had no effect in High-Fit subjects. Conclusion: Higher levels of cardiorespiratory fitness may attenuate the risk of atherosclerosis associated with ADRB3 Trp64Arg polymorphism.

Original languageEnglish
Pages (from-to)1421-1428
Number of pages8
JournalEuropean Journal of Applied Physiology
Volume114
Issue number7
DOIs
Publication statusPublished - 2014

Fingerprint

Atherosclerosis
Carotid Intima-Media Thickness
Cardiovascular Diseases
Genotype
Exercise
Lipids
Adrenergic Receptors
HDL Cholesterol
Weight Gain
Insulin Resistance
Adipose Tissue
Triglycerides
Biomarkers
Cardiorespiratory Fitness
Oxygen
Glucose

Keywords

  • Arterial stiffness
  • Carotid artery
  • Intima-media thickness
  • Peak oxygen uptake

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Orthopedics and Sports Medicine
  • Physiology (medical)
  • Medicine(all)

Cite this

Higher cardiorespiratory fitness attenuates the risk of atherosclerosis associated with ADRB3 Trp64Arg polymorphism. / Iemitsu, Motoyuki; Fujie, Shumpei; Murakami, Haruka; Sanada, Kiyoshi; Kawano, Hiroshi; Gando, Yuko; Kawakami, Ryoko; Tanaka, Noriko; Miyachi, Motohiko.

In: European Journal of Applied Physiology, Vol. 114, No. 7, 2014, p. 1421-1428.

Research output: Contribution to journalArticle

Iemitsu, Motoyuki ; Fujie, Shumpei ; Murakami, Haruka ; Sanada, Kiyoshi ; Kawano, Hiroshi ; Gando, Yuko ; Kawakami, Ryoko ; Tanaka, Noriko ; Miyachi, Motohiko. / Higher cardiorespiratory fitness attenuates the risk of atherosclerosis associated with ADRB3 Trp64Arg polymorphism. In: European Journal of Applied Physiology. 2014 ; Vol. 114, No. 7. pp. 1421-1428.
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abstract = "Purpose: β3-Adrenergic receptor (ADRB3) Trp64Arg polymorphism is associated with atherogenic risk factors that include weight gain, insulin resistance, and diabetes. Habitual exercise brings higher cardiorespiratory fitness and results in the amelioration of atherosclerotic risk factors. However, the effects of cardiorespiratory fitness level and ADRB3 Trp64Arg polymorphism on the risk of cardiovascular disease remain unclear. A cross-sectional investigation of 877 Japanese men and women (18-75 years old) was performed to clarify the effects of cardiorespiratory fitness on the relationship between ADRB3 Trp64Arg polymorphism and risk of cardiovascular disease. Method: Common carotid intima-media thickness (ccIMT) and blood lipid profiles were assessed as surrogate markers of atherosclerosis. We measured peak oxygen uptake (V ̇ O2peak) during incremental cycle ergometer exercise testing. Subjects were divided into groups with high (High-Fit) and low (Low-Fit) levels of cardiorespiratory fitness based on the median value of V ̇ O2peak for sex and decade. Results: Levels of body fat, triglycerides, and plasma glucose were lower and high-density lipoprotein cholesterol levels and V ̇ O2peak were higher in High-Fit subjects than Low-Fit subjects. ADRB3 Trp64Arg polymorphism did not significantly affect ccIMT or blood lipid profiles. In Low-Fit subjects, ccIMT was higher in individuals with the Arg/Arg genotype compared to the Trp/Trp and Trp/Arg genotypes (each P < 0.0001); however, ADRB3 polymorphism had no effect in High-Fit subjects. Conclusion: Higher levels of cardiorespiratory fitness may attenuate the risk of atherosclerosis associated with ADRB3 Trp64Arg polymorphism.",
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T1 - Higher cardiorespiratory fitness attenuates the risk of atherosclerosis associated with ADRB3 Trp64Arg polymorphism

AU - Iemitsu, Motoyuki

AU - Fujie, Shumpei

AU - Murakami, Haruka

AU - Sanada, Kiyoshi

AU - Kawano, Hiroshi

AU - Gando, Yuko

AU - Kawakami, Ryoko

AU - Tanaka, Noriko

AU - Miyachi, Motohiko

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N2 - Purpose: β3-Adrenergic receptor (ADRB3) Trp64Arg polymorphism is associated with atherogenic risk factors that include weight gain, insulin resistance, and diabetes. Habitual exercise brings higher cardiorespiratory fitness and results in the amelioration of atherosclerotic risk factors. However, the effects of cardiorespiratory fitness level and ADRB3 Trp64Arg polymorphism on the risk of cardiovascular disease remain unclear. A cross-sectional investigation of 877 Japanese men and women (18-75 years old) was performed to clarify the effects of cardiorespiratory fitness on the relationship between ADRB3 Trp64Arg polymorphism and risk of cardiovascular disease. Method: Common carotid intima-media thickness (ccIMT) and blood lipid profiles were assessed as surrogate markers of atherosclerosis. We measured peak oxygen uptake (V ̇ O2peak) during incremental cycle ergometer exercise testing. Subjects were divided into groups with high (High-Fit) and low (Low-Fit) levels of cardiorespiratory fitness based on the median value of V ̇ O2peak for sex and decade. Results: Levels of body fat, triglycerides, and plasma glucose were lower and high-density lipoprotein cholesterol levels and V ̇ O2peak were higher in High-Fit subjects than Low-Fit subjects. ADRB3 Trp64Arg polymorphism did not significantly affect ccIMT or blood lipid profiles. In Low-Fit subjects, ccIMT was higher in individuals with the Arg/Arg genotype compared to the Trp/Trp and Trp/Arg genotypes (each P < 0.0001); however, ADRB3 polymorphism had no effect in High-Fit subjects. Conclusion: Higher levels of cardiorespiratory fitness may attenuate the risk of atherosclerosis associated with ADRB3 Trp64Arg polymorphism.

AB - Purpose: β3-Adrenergic receptor (ADRB3) Trp64Arg polymorphism is associated with atherogenic risk factors that include weight gain, insulin resistance, and diabetes. Habitual exercise brings higher cardiorespiratory fitness and results in the amelioration of atherosclerotic risk factors. However, the effects of cardiorespiratory fitness level and ADRB3 Trp64Arg polymorphism on the risk of cardiovascular disease remain unclear. A cross-sectional investigation of 877 Japanese men and women (18-75 years old) was performed to clarify the effects of cardiorespiratory fitness on the relationship between ADRB3 Trp64Arg polymorphism and risk of cardiovascular disease. Method: Common carotid intima-media thickness (ccIMT) and blood lipid profiles were assessed as surrogate markers of atherosclerosis. We measured peak oxygen uptake (V ̇ O2peak) during incremental cycle ergometer exercise testing. Subjects were divided into groups with high (High-Fit) and low (Low-Fit) levels of cardiorespiratory fitness based on the median value of V ̇ O2peak for sex and decade. Results: Levels of body fat, triglycerides, and plasma glucose were lower and high-density lipoprotein cholesterol levels and V ̇ O2peak were higher in High-Fit subjects than Low-Fit subjects. ADRB3 Trp64Arg polymorphism did not significantly affect ccIMT or blood lipid profiles. In Low-Fit subjects, ccIMT was higher in individuals with the Arg/Arg genotype compared to the Trp/Trp and Trp/Arg genotypes (each P < 0.0001); however, ADRB3 polymorphism had no effect in High-Fit subjects. Conclusion: Higher levels of cardiorespiratory fitness may attenuate the risk of atherosclerosis associated with ADRB3 Trp64Arg polymorphism.

KW - Arterial stiffness

KW - Carotid artery

KW - Intima-media thickness

KW - Peak oxygen uptake

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