Highly enantioselective addition of dialkylzincs to aromatic aldehydes using 1-phenyl-2-(1-pyrrolidinyl)-1-propanol as a chiral catalyst

Kenso Soai, Takashi Konishi, Takanori Shibata

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

(1S,2R)- and (1R,2S)-1-phenyl-2-(1-pyrrolidinyl)-1-propanol catalyzes the enantioselective addition of dialkylzincs to aromatic aldehydes to afford enantiomerically enriched aromatic, sec-alcohols with up to 92% enantiomeric excess.

Original languageEnglish
Pages (from-to)1421-1426
Number of pages6
JournalHeterocycles
Volume51
Issue number6
DOIs
Publication statusPublished - 1999 Jun 1

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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