Highly enantioselective preparation of tricyclo[4.4.0.05,7]decene derivatives via catalytic asymmetric intramolecular cyclopropanation reactions of α-diazo-β-keto esters

Ryoji Ida, Masahisa Nakada

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The enantioselective preparation of the tricyclo[4.4.0.05,7]dec-2-ene derivatives via the catalytic asymmetric intramolecular cyclopropanation (CAIMCP) reactions of α-diazo-β-keto esters with excellent ee (95-98% ee) is described. The chiral building blocks reported herein would be versatile intermediates for enantioselective natural products synthesis.

Original languageEnglish
Pages (from-to)4855-4859
Number of pages5
JournalTetrahedron Letters
Volume48
Issue number28
DOIs
Publication statusPublished - 2007 Jul 9

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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