Highly enantioselective preparation of tricyclo[4.4.0.05,7]decene derivatives via catalytic asymmetric intramolecular cyclopropanation reactions of α-diazo-β-keto esters

Ryoji Ida, Masahisa Nakada

    Research output: Contribution to journalArticle

    25 Citations (Scopus)

    Abstract

    The enantioselective preparation of the tricyclo[4.4.0.05,7]dec-2-ene derivatives via the catalytic asymmetric intramolecular cyclopropanation (CAIMCP) reactions of α-diazo-β-keto esters with excellent ee (95-98% ee) is described. The chiral building blocks reported herein would be versatile intermediates for enantioselective natural products synthesis.

    Original languageEnglish
    Pages (from-to)4855-4859
    Number of pages5
    JournalTetrahedron Letters
    Volume48
    Issue number28
    DOIs
    Publication statusPublished - 2007 Jul 9

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    Biological Products
    Esters
    Derivatives

    ASJC Scopus subject areas

    • Biochemistry
    • Organic Chemistry
    • Drug Discovery

    Cite this

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    abstract = "The enantioselective preparation of the tricyclo[4.4.0.05,7]dec-2-ene derivatives via the catalytic asymmetric intramolecular cyclopropanation (CAIMCP) reactions of α-diazo-β-keto esters with excellent ee (95-98{\%} ee) is described. The chiral building blocks reported herein would be versatile intermediates for enantioselective natural products synthesis.",
    author = "Ryoji Ida and Masahisa Nakada",
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    T1 - Highly enantioselective preparation of tricyclo[4.4.0.05,7]decene derivatives via catalytic asymmetric intramolecular cyclopropanation reactions of α-diazo-β-keto esters

    AU - Ida, Ryoji

    AU - Nakada, Masahisa

    PY - 2007/7/9

    Y1 - 2007/7/9

    N2 - The enantioselective preparation of the tricyclo[4.4.0.05,7]dec-2-ene derivatives via the catalytic asymmetric intramolecular cyclopropanation (CAIMCP) reactions of α-diazo-β-keto esters with excellent ee (95-98% ee) is described. The chiral building blocks reported herein would be versatile intermediates for enantioselective natural products synthesis.

    AB - The enantioselective preparation of the tricyclo[4.4.0.05,7]dec-2-ene derivatives via the catalytic asymmetric intramolecular cyclopropanation (CAIMCP) reactions of α-diazo-β-keto esters with excellent ee (95-98% ee) is described. The chiral building blocks reported herein would be versatile intermediates for enantioselective natural products synthesis.

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    U2 - 10.1016/j.tetlet.2007.05.046

    DO - 10.1016/j.tetlet.2007.05.046

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    JO - Tetrahedron Letters

    JF - Tetrahedron Letters

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    ER -