Highly enantioselective synthesis of a chiral 3-quinolylalkanol by an asymmetric autocatalytic reaction

Takanori Shibata, Kaori Choji, Hiroshi Morioka, Tadakatsu Hayase, Kenso Soai

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

A catalytic amount of a chiral zinc alkoxide of 2-methyl-1-(3-quinolyl)propan-1-ol catalyses the enantioselective alkylation of quinoline-3-carbaldehyde by diisopropylzine to afford 2-methyl-1-(3-quinolyl)propan-1-ol with the same configuration in high ee (up to 94%).

Original languageEnglish
Pages (from-to)751-752
Number of pages2
JournalChemical Communications
Issue number6
Publication statusPublished - 1996
Externally publishedYes

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Alkylation
Zinc
quinoline

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Highly enantioselective synthesis of a chiral 3-quinolylalkanol by an asymmetric autocatalytic reaction. / Shibata, Takanori; Choji, Kaori; Morioka, Hiroshi; Hayase, Tadakatsu; Soai, Kenso.

In: Chemical Communications, No. 6, 1996, p. 751-752.

Research output: Contribution to journalArticle

Shibata, Takanori ; Choji, Kaori ; Morioka, Hiroshi ; Hayase, Tadakatsu ; Soai, Kenso. / Highly enantioselective synthesis of a chiral 3-quinolylalkanol by an asymmetric autocatalytic reaction. In: Chemical Communications. 1996 ; No. 6. pp. 751-752.
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