Hindered biaryls by C-H coupling: Bisoxazoline-Pd catalysis leading to enantioselective C-H coupling

Kazuya Yamaguchi, Junichiro Yamaguchi, Armido Studer, Kenichiro Itami

Research output: Contribution to journalArticle

124 Citations (Scopus)

Abstract

A new Pd-catalyzed C-H/C-B coupling of sterically hindered heteroarenes and arylboronic acids has been identified. The newly established Pd(OAc) 2/bisoxazoline/TEMPO system not only enables the synthesis of sterically hindered heterobiaryls but also offers an opportunity for enantioselective biaryl coupling through C-H functionalization.

Original languageEnglish
Pages (from-to)2165-2169
Number of pages5
JournalChemical Science
Volume3
Issue number6
DOIs
Publication statusPublished - 2012 Jun 1

ASJC Scopus subject areas

  • Chemistry(all)

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