Hindered biaryls by C-H coupling

Bisoxazoline-Pd catalysis leading to enantioselective C-H coupling

Kazuya Yamaguchi, Junichiro Yamaguchi, Armido Studer, Kenichiro Itami

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

A new Pd-catalyzed C-H/C-B coupling of sterically hindered heteroarenes and arylboronic acids has been identified. The newly established Pd(OAc) 2/bisoxazoline/TEMPO system not only enables the synthesis of sterically hindered heterobiaryls but also offers an opportunity for enantioselective biaryl coupling through C-H functionalization.

Original languageEnglish
Pages (from-to)2165-2169
Number of pages5
JournalChemical Science
Volume3
Issue number6
DOIs
Publication statusPublished - 2012 Jun
Externally publishedYes

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Catalysis
Acids
TEMPO
palladium(II) acetate

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Hindered biaryls by C-H coupling : Bisoxazoline-Pd catalysis leading to enantioselective C-H coupling. / Yamaguchi, Kazuya; Yamaguchi, Junichiro; Studer, Armido; Itami, Kenichiro.

In: Chemical Science, Vol. 3, No. 6, 06.2012, p. 2165-2169.

Research output: Contribution to journalArticle

Yamaguchi, Kazuya ; Yamaguchi, Junichiro ; Studer, Armido ; Itami, Kenichiro. / Hindered biaryls by C-H coupling : Bisoxazoline-Pd catalysis leading to enantioselective C-H coupling. In: Chemical Science. 2012 ; Vol. 3, No. 6. pp. 2165-2169.
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