Histological and molecular characterization of the femoral attachment of the human ligamentum capitis femoris

Y. Shinohara, Tsukasa Kumai, I. Higashiyama, K. Hayashi, T. Matsuda, Y. Tanaka, Y. Takakura

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The ligamentum capitis femoris (LCF) has increased in clinical significance through the development of hip arthroscopy. The histological pathologies and molecular composition of the femoral attachment of the LCF and the degeneration caused by LCF disruption were investigated in the human hip joint. Twenty-four LCFs were retrieved at surgery for femoral neck fracture (age range: 63-87 years). In the "intact" (i.e., intact throughout its length, n=12) group, the attachment consisted of rich fibrocartilage. Fibrocartilage cells were present in the midsubstance. In contrast, the construction of the attachment in the "disrupted" (i.e., ligament no longer attached to the femoral head, n=12) group had disappeared. The attachment in the disrupted group was not labeled for type II collagen or aggrecan, while that in the intact group was labeled for types I, II and III collagen, chondroitin 4-sulfate, chondroitin 6-sulfate, aggrecan, and versican. The percentage of single-stranded DNA-positive chondrocytes was significantly higher in the disrupted group than in the intact group. We conclude that the femoral attachment of the LCF has a characteristic fibrocartilaginous structure that is likely to adjust to the mechanical load, and suggest that its degeneration is advanced by disruption and should be regarded as a clinical pathology.

Original languageEnglish
JournalScandinavian Journal of Medicine and Science in Sports
Volume24
Issue number4
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

Thigh
Fibrocartilage
Aggrecans
Collagen Type II
Chondroitin Sulfates
Versicans
Femoral Neck Fractures
Clinical Pathology
Collagen Type III
Molecular Pathology
Single-Stranded DNA
Arthroscopy
Hip Joint
Chondrocytes
Collagen Type I
Ligaments
Hip
Round Ligament of Femur

Keywords

  • Enthesis
  • Ligament rupture
  • Stability
  • Stress deprivation

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Histological and molecular characterization of the femoral attachment of the human ligamentum capitis femoris. / Shinohara, Y.; Kumai, Tsukasa; Higashiyama, I.; Hayashi, K.; Matsuda, T.; Tanaka, Y.; Takakura, Y.

In: Scandinavian Journal of Medicine and Science in Sports, Vol. 24, No. 4, 2014.

Research output: Contribution to journalArticle

Shinohara, Y. ; Kumai, Tsukasa ; Higashiyama, I. ; Hayashi, K. ; Matsuda, T. ; Tanaka, Y. ; Takakura, Y. / Histological and molecular characterization of the femoral attachment of the human ligamentum capitis femoris. In: Scandinavian Journal of Medicine and Science in Sports. 2014 ; Vol. 24, No. 4.
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